Hyperbaric oxygen therapy for deep second degree burns: an experimental studyin the guinea pig

Shoshani, Oren; Shupak, Avi; Barak, Ami; Ullman, Yehuda; Ramon, Yitzchak; Lindenbaum, Ella S.; Peled, Yitzchak

doi:10.1054/bjps.1997.0060

Cited by 19 publications

(4 citation statements)

References 32 publications

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“…The method of evaluation was adapted from previous publications. 21,33 Standardized digital wound photographs were taken on days 7, 21, and (where applicable) day 42, using a Minolta DiMAGE 7 digital camera (Minolta Co. Ltd., Osaka, Japan) on macro setting. Distances were calibrated with a ruler on each photograph, using Leica Qwin software (Leica Microsystems Imaging Solutions Ltd., UK).…”

Section: Morphometrical Evaluation Of the Woundsmentioning

confidence: 99%

“…1,3,5,11-15,17-24,26 -29,31-40 The method of creation of the wound can also vary. Wounds were created surgically, 1,11,14,18,19,21,25-28,30,38 -40 with a punch biopsy, 3,[11][12][13]15,20,22,24,29,35,37 or thermally; these were either contact burns, 14,23,33,34,36 scald burns, 17,31,36 or radiation-induced burns. 12 The size of the wounds also varied, from 3-8 mm 3,11,12,15,20,22,24,29,35,37 to 5-6 cm.…”

Section: Introductionmentioning

confidence: 99%

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Transforming growth factor‐β3–loaded microtextured membranes for skin regeneration in dermal wounds

Vooijs

Walboomers

Parker

et al. 2004

J Biomedical Materials Res

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Adverse effects of wound healing, such as excessive scar tissue formation, wound contraction, or nonhealing wounds represent a major clinical issue in today's healthcare. Transforming growth factor (TGF)-beta3 has specifically been implicated in wound healing. Our hypothesis was that local administration of TGF-beta3 to excisional dermal wounds would diminish wound contraction and scar formation. Microtextured wound covers, containing different concentrations of TGF-beta3, were placed onto full-thickness excisional skin wounds in guinea pigs. Tattooed reference marks were used to quantify wound contraction. Sixty-four male guinea pigs in four study groups (5 ng TGF-beta3, 50 ng TGF-beta3, no growth factor, sham wound) were followed for up to 6 weeks. We analyzed 19 different parameters of wound healing. Results showed that, in some instances, the 50-ng TGF-beta3 group gave less contraction, whereas the 5-ng TGF-beta3 group gave more contraction. These differences confirm that TGF-beta3 has an optimum working concentration, and suggest this concentration to be closer to 50 ng than to 5 ng TGF-beta3. However, only very few significant differences occurred, and thus we conclude that the clinical relevance of our findings is negligible. Earlier studies, reporting clinically improved wound healing by TGF-beta3, could therefore not be confirmed by this study.

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Section: Morphometrical Evaluation Of the Woundsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transforming growth factor‐β3–loaded microtextured membranes for skin regeneration in dermal wounds

Vooijs

Walboomers

Parker

et al. 2004

J Biomedical Materials Res

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“…Significantly increased wound epidermization was only observed in the group subjected to normobaric oxygen therapy, ten days after the sustained injury. Study results suggest that the increased tissue PO 2 level can impair the healing of the burn wound (57).…”

Section: Clinical Studiesmentioning

confidence: 89%

Hyperbaric Oxygen Therapy of Burns

Strużyna¹,

Staroń²,

Krajewski³

2008

Polish Journal of Surgery

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“…We can speculate that hyperbaric oxygen therapy influences the epithelialization of burn wounds by minimizing the detrimental effect of hypoxia and encouraging a faster proliferation rate and migration of epithelial cells. However, regarding this hypothesis, there are conflicting results about the role of HBO in the epithelialization of second-degree burns [ 35 , 36 ]. Our findings are in line with Hatibie and colleagues, who elegantly demonstrated the beneficial effects of HBO and concluded that adequate oxygen is mandatory for wound healing [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Administration of Hyperbaric Oxygen Therapy and Antioxidant Supplementation with Filipendula ulmaria Extract in the Treatment of Thermal Skin Injuries Alters Nociceptive Signalling and Wound Healing

Krstic,

Jovicic,

Selakovic

et al. 2023

Medicina

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Background and Objectives: Thermal skin injuries are a prevalent cause of skin damage, potentially leading to severe morbidity and significant mortality. In this study, we intended to estimate the effects of HBO (hyperbaric oxygen treatment) and antioxidant supplementation with Filipendula ulmaria extract, individually and simultaneously, in the treatment of thermal skin injuries. Materials and Methods: As a thermal skin injury experimental model, we used two-month-old male Wistar albino rats. Thermal injuries were made with a solid aluminium bar at a constant temperature of 75 °C for 15 s. Hyperbaric oxygen treatment was performed in a specially constructed hyperbaric chamber for rats (HYB-C 300) for seven consecutive days (100% O2 at 2.5 ATA for 60 min). Antioxidant supplementation was performed with oral administration of Filipendula ulmaria extract dissolved in tap water to reach a final concentration of 100 mg/kg b.w. for seven consecutive days. Results: Simultaneous administration of hyperbaric oxygen therapy and antioxidant supplementation with Filipendula ulmaria extract significantly ameliorated the macroscopic and histopathological characteristics of the wound area and healing. Also, this therapeutic approach decreased the local expression of genes for proinflammatory mediators and increased the expression of the μ-opioid receptor and the MT1 and MT2 receptors in the wound area and spinal cord, with a consequent increase in reaction times in behavioural testing. Conclusions: In conclusion, the presented results of our study allow evidence for the advantages of the simultaneous employment of HBO and antioxidant supplementation in the treatment of thermal skin injuries, with special reference to the attenuation of painful sensations accompanied by this type of trauma.

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Hyperbaric oxygen therapy for deep second degree burns: an experimental studyin the guinea pig

Cited by 19 publications

References 32 publications

Transforming growth factor‐β3–loaded microtextured membranes for skin regeneration in dermal wounds

Transforming growth factor‐β3–loaded microtextured membranes for skin regeneration in dermal wounds

Hyperbaric Oxygen Therapy of Burns

Simultaneous Administration of Hyperbaric Oxygen Therapy and Antioxidant Supplementation with Filipendula ulmaria Extract in the Treatment of Thermal Skin Injuries Alters Nociceptive Signalling and Wound Healing

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