Hyperbaric oxygen therapy for late radiation tissue injury

Bennett, Michael H; Feldmeier, John J.; Hampson, Neil B.; Smee, Robert; Milross, Christopher G.

doi:10.1002/14651858.cd005005.pub3

Cited by 125 publications

(177 citation statements)

References 29 publications

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“…The review showed evidence that late radiation tissue injury affecting head, neck, and lower end of bowel can be improved with hyperbaric oxygen therapy. 46 While most studies are not randomized and lack appropriate controls, one randomized controlled double-blind crossover trial of 226 patients indicated that hyperbaric oxygen significantly improved healing responses in patients with refractory radiation proctitis with an absolute risk reduction of 32% with resulting improved bowel-specific quality of life. 47 …”

Section: Methodsmentioning

confidence: 99%

Cervical Cancer Survivorship: Long-term Quality of Life and Social Support

Pfaendler

Wenzel

Mechanic

et al. 2015

Clinical Therapeutics

151

113

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Purpose Surgery, radiotherapy and chemotherapy are the mainstays of cervical cancer treatment. Many patients receive multiple treatment modalities, each with its own long-term effects. Given the high 5 year survival rate for cervical cancer patients, evaluation and improvement of long-term quality of life are essential. Methods Pertinent articles were identified through searches of PubMed for literature published from 1993-2014. We summarize quality of life data from long-term follow up studies of cervical cancer patients. We additionally summarize small group interviews of Hispanic and non-Hispanic cervical cancer survivors regarding social support and coping. Findings Data is varied in terms of the long term impact of treatment on quality of life but consistent in suggesting that patients who receive radiotherapy as part of their treatment have the highest risk of increased long term dysfunction of bladder and bowel, as well as sexual dysfunction and psychosocial consequences. Rigorous investigations regarding long-term consequences of treatment modalities are lacking. Implications Continued work to improve treatment outcomes and survival should also include a focus on reducing adverse long-term side effects. Providing supportive care during treatment, and evaluating the effects of supportive care, may reduce the prevalence and magnitude of long-term sequelae of cervical cancer, which will in turn improve quality of life and quality of care.

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Section: Methodsmentioning

confidence: 99%

Cervical Cancer Survivorship: Long-term Quality of Life and Social Support

Pfaendler

Wenzel

Mechanic

et al. 2015

Clinical Therapeutics

151

113

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“…In addition, hyperbaric oxygen has been applied for the management of several chronic radiation injury forms [39–41]. A significant interpretation of the literature on the efficacy of hyperbaric oxygen treatment in this context is complicated by the heterogeneity of the treated disease, the various tissue damage types, and the several toxicity scoring systems used.…”

Section: Resultsmentioning

confidence: 99%

“…A significant interpretation of the literature on the efficacy of hyperbaric oxygen treatment in this context is complicated by the heterogeneity of the treated disease, the various tissue damage types, and the several toxicity scoring systems used. Few randomized controlled trials using oxygen therapy for the management of chronic radiation injury have been investigated; however, the findings appear promising for some subgroups such as head and neck patients and for those with proctitis as a result of radiation [39]. …”

Section: Resultsmentioning

confidence: 99%

Cellular Preoxygenation Partially Attenuates the Antitumoral Effect of Cisplatin despite Highly Protective Effects on Renal Epithelial Cells

Rasoulian

Kaeidi

Rezaei

et al. 2017

Oxidative Medicine and Cellular Longevity

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Our previous in vitro studies demonstrated that oxygen pretreatment significantly protects human embryonic renal tubular cell against acute cisplatin- (CP-) induced cytotoxicity. The present study was designed to investigate whether this protective effect is associated with decreasing therapeutic effects of cisplatin on malignant cells. For this purpose, cultured human embryonic kidney epithelial-like (AD293), cervical carcinoma epithelial-like (Hela), and ovarian adenocarcinoma epithelial-like (OVCAR-3) cells were subjected to either 2-hour pretreatment with oxygen (≥90%) or normal air and then to a previously determined 50% lethal dose of cisplatin for 24 hours. Cellular viability was evaluated via MTT and Neutral Red assays. Also, activated caspase-3 and Bax/Bcl-2 ratio, as the biochemical markers of cell apoptosis, were determined using immunoblotting. The hyperoxic preexposure protocol significantly protects renal AD293 cells against cisplatin-induced toxicity. Oxygen pretreatment also partially attenuated the cisplatin-induced cytotoxic effects on Hela and OVCAR-3 cells. However, it did not completely protect these cells against the therapeutic cytotoxic effects of cisplatin. In summary, the protective methods for reducing cisplatin nephrotoxic side effects like oxygen pretreatment might be associated with concurrent reduction of the therapeutic cytotoxic effects of cisplatin on malignant cells like cervical carcinoma (Hela) and ovarian adenocarcinoma (OVCAR-3) cells.

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“…Recent Cochrane review demonstrated there was a significantly increased chance of improvement or cure following hyperbaric oxygen therapy for RP [8].…”

Section: Discussionmentioning

confidence: 99%

Radiation Proctitis: Case Series of Treatment With Argon Plasma Coagulation in Klaipeda University Hospital

et al. 2017

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Radiation proctopathy is defined as rectal damage due to radiation with or without inflammation. Objectives and methods. The aim of this study was to present our clinical experience, regarding the argon plasma coagulation, in a small series of patients with radiation proctitis. Retrospective data analysis of patients treated for radiation proctitis in a single hospital setting from year 2014 to 2017 was performed. Statistical data analysis was carried out using the SPSS 20.0 software. Results. 13 patients underwent argon plasma coagulation. The female and male ratio was 1:2,25. The mean age of the patients was 70,69±13,51 years. All men (n=9) had radiotherapy due to prostate cancer and cervical cancer was the main cause in women group (n=4). Six patients (46%) had second plasma coagulation done. Three patients (23%) had endoscopic argon plasma coagulation. Mean hospital stay was 4,47±8,83 days. Necrosis of mucous membrane was observed in one patient (7,69%). Conclusion. There is no evidence-based consensus regarding treatment of radiation proctitis. Argon plasma coagulation seems to be safe and effective choice of treatment, but further studies are required to determine which methods should be considered as the ,,gold standard” choice.

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Hyperbaric oxygen therapy for late radiation tissue injury

Cited by 125 publications

References 29 publications

Cervical Cancer Survivorship: Long-term Quality of Life and Social Support

Cervical Cancer Survivorship: Long-term Quality of Life and Social Support

Cellular Preoxygenation Partially Attenuates the Antitumoral Effect of Cisplatin despite Highly Protective Effects on Renal Epithelial Cells

Radiation Proctitis: Case Series of Treatment With Argon Plasma Coagulation in Klaipeda University Hospital

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