Hyperbaric oxygen therapy for late radiation tissue injury in gynaecological patients

Rud, A. Kongsgaard; Bjørgo, Steinar; Kristensen, Gunnar B.; Kongsgaard, Ulf E.

doi:10.1007/s00520-009-0619-1

Cited by 6 publications

(14 citation statements)

References 18 publications

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“…A study by Rud et al. (), aiming to reduce pelvic pain after radiation, showed no detectable effect of hyperbaric oxygen therapy, even though some patients experienced relief in overall symptom burden. Finally, Nord et al.…”

Section: Resultsmentioning

confidence: 99%

Lived experiences and quality of life after gynaecological cancer—An integrative review

Sekse

Dunberger²,

Olesen

et al. 2019

Journal of Clinical Nursing

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Aim and objectives To review the literature on Nordic women's lived experiences and quality of life (QoL) after gynaecological cancer treatment. Background While incidence and survival are increasing in all groups of gynaecological cancers in the Nordic countries, inpatient hospitalisation has become shorter in relation to treatment. This has increased the need for follow‐up and rehabilitation. Design Integrative literature review using the Equator PRISMA guidelines. Methods The review was selected, allowing inclusion of both experimental and nonexperimental research. The search included peer‐reviewed articles published 1995–2017. To frame the search strategy, we applied the concept of rehabilitation, which holds a holistic perspective on health. Results Fifty‐five articles were included and were contextualised within three themes. Physical well-being in a changed body encompasses bodily changes comprising menopausal symptoms, a changed sexual life, complications in bowels, urinary tract, lymphoedema and pain, bodily‐based preparedness and fear of recurrence. Mental well-being as a woman deals with questioned womanliness, the experience of revitalised values in life, and challenges of how to come to terms with oneself after cancer treatment. Psychosocial well-being and interaction deals with the importance of having a partner or close person in the process of coming to terms with oneself after cancer. Furthermore, the women needed conversations with health professionals around the process of coping with changes and late effects, including intimate and sensitive issues. Conclusion Years after gynaecological cancer, women have to deal with fundamental changes and challenges concerning their physical, mental and psychosocial well‐being. Future research should focus on how follow‐up programmes can be organised to target the multidimensional aspects of women's QoL. Research collaboration across Nordic countries on rehabilitation needs and intervention is timely and welcomed. Relevance to clinical practice To ensure that all aspects of cancer rehabilitation are being addressed, we suggest that the individual woman is offered an active role in her follow‐up.

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Section: Resultsmentioning

confidence: 99%

Lived experiences and quality of life after gynaecological cancer—An integrative review

Sekse

Dunberger²,

Olesen

et al. 2019

Journal of Clinical Nursing

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“…All patients with vaginal radiation necrosis or rectovaginal fistula experienced complete resolution of necrosis with HBO 2 ; only 1 treatment failure occurred. Other studies have found similarly positive effects and response rates for a range of clinical features of lrti, including proctitis, cystitis, proctitis and other gastrointestinal complications, and pain [22][23][24][25][26][27] .…”

Section: Resultsmentioning

confidence: 99%

“…Among women experiencing lrti from treatment for gynecologic malignancies, the response rate to HBO 2 is of the order of 70%. Studies have found positive effects and a range of specific response rates for various clinical features of lrti (including cystitis, proctitis, and other gastrointestinal complications) and pain [23][24][25][26][27] . There is some evidence to suggest that outcomes are better when HBO 2 is initiated by 6 months from the start of symptoms rather than being delayed beyond that point 26 .…”

Section: Resultsmentioning

confidence: 99%

“…Table i summarizes key studies, which include retrospective, prospective, and case studies and randomized controlled trials. Further details of the studies and other relevant publications 12,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] are available on the Current Oncology Web site.…”

Section: Synthesizing the Evidencementioning

confidence: 99%

“…From among the 13 full-text articles, two randomized controlled trials 19,20 , eleven nonrandomized studies [21][22][23][24][25][26][27][28][29][30][31] , and five additional supporting documents 12,[32][33][34][35] representing indirect evidence, were considered eligible for inclusion. They comprise the evidence base for the systematic review of the literature.…”

Section: Literature Search Strategymentioning

confidence: 99%

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Hyperbaric Oxygen Therapy for Late Radiation Tissue Injury in Gynecologic Malignancies

et al. 2011

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Background: Late radiation tissue injury is a serious complication of radiotherapy for patients with gynecologic malignancies. Strategies for managing pain and other clinical features have limited efficacy; however, hyperbaric oxygen therapy (HBO2) may be an effective option for some patients. Methods: In a systematic review of the literature, the Ovid medline, embase, Cochrane Library, National Guidelines Clearinghouse, and Canadian Medical Association Infobase databases were searched to June 2009 for clinical practice guidelines, systematic reviews, randomized controlled trials, or other relevant evidence. Studies that did not evaluate soft tissue necrosis, cystitis, proctitis, bone necrosis, and other complications were excluded. Results: Two randomized trials, eleven nonrandomized studies, and five supporting documents comprise the evidence base. In addition, information on the harms and safety of treatment with HBO2 were reported in three additional sources. There is modest direct evidence and emerging indirect evidence that the use of HBO2 is broadly effective for late radiation tissue injury of the pelvis in women treated for gynecologic malignancies. Conclusions: Based on the evidence and expert consensus opinion, (1) HBO2 is likely effective for late radiation tissue injury of the pelvis, with demonstrated efficacy specifically for radiation damage to the anus and rectum; (2) the main indication for HBO2 therapy in gynecologic oncology is in the management of otherwise refractory chronic radiation injury; (3) HBO2 may provide symptomatic benefit in certain clinical settings (for example, cystitis, soft-tissue necrosis, and osteonecrosis); (4) and HBO2 may reduce the complications of gynecologic surgery in patients undergoing surgical removal of necrosis.

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Prospective Pilot study of Quality of Life in patients with severe late-radiation-toxicity treated by Low hyperbaric-oxigen-therapy

Rosas¹,

Aguiar²,

Domínguez³

et al. 2023

Clinical and Translational Radiation Oncology

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Hyperbaric oxygen therapy for late radiation tissue injury in gynaecological patients

Cited by 6 publications

References 18 publications

Lived experiences and quality of life after gynaecological cancer—An integrative review

Lived experiences and quality of life after gynaecological cancer—An integrative review

Hyperbaric Oxygen Therapy for Late Radiation Tissue Injury in Gynecologic Malignancies

Prospective Pilot study of Quality of Life in patients with severe late-radiation-toxicity treated by Low hyperbaric-oxigen-therapy

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