Hyperbaric oxygen therapy for the treatment of children and youth with Autism Spectrum Disorders: An evidence-based systematic review

Goldfarb, Cynthia; Genore, Lisa; Hunt, Carolyn; Flanagan, Janine; Handley-Derry, Mark; Jethwa, Anita; Jones-Stokreef, Nicola; Kirkpatrick, Sara; Richards, Alison; Rojnica, Lillian; Schwartz, Clive; Shawn, David; Superina-Bell, Diann; Young, Elizabeth; Anagnostou, Evdokia

doi:10.1016/j.rasd.2016.05.004

Cited by 9 publications

(8 citation statements)

References 17 publications

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“…Moreover, the available evidence indicates that secretin treatment is not effective (Sandler et al, 1999). Chelation and hyperbaric oxygen therapy are potentially harmful with little evidence of benefit and should not be used to manage ASD in any context (Davis et al, 2013; Goldfarb et al, 2016; National Institute for Clinical Excellence, 2012).…”

Section: Non-pharmacological Approaches For Core Symptoms Of Asd In Cmentioning

confidence: 99%

Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology

et al. 2017

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An expert review of the aetiology, assessment, and treatment of autism spectrum disorder, and recommendations for diagnosis, management and service provision was coordinated by the British Association for Psychopharmacology, and evidence graded. The aetiology of autism spectrum disorder involves genetic and environmental contributions, and implicates a number of brain systems, in particular the gamma-aminobutyric acid, serotonergic and glutamatergic systems. The presentation of autism spectrum disorder varies widely and co-occurring health problems (in particular epilepsy, sleep disorders, anxiety, depression, attention deficit/hyperactivity disorder and irritability) are common. We did not recommend the routine use of any pharmacological treatment for the core symptoms of autism spectrum disorder. In children, melatonin may be useful to treat sleep problems, dopamine blockers for irritability, and methylphenidate, atomoxetine and guanfacine for attention deficit/hyperactivity disorder. The evidence for use of medication in adults is limited and recommendations are largely based on extrapolations from studies in children and patients without autism spectrum disorder. We discuss the conditions for considering and evaluating a trial of medication treatment, when non-pharmacological interventions should be considered, and make recommendations on service delivery. Finally, we identify key gaps and limitations in the current evidence base and make recommendations for future research and the design of clinical trials.

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Section: Non-pharmacological Approaches For Core Symptoms Of Asd In Cmentioning

confidence: 99%

Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology

et al. 2017

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“…55,[69][70][71][72] Although the evidence base for the effectiveness of various therapies is increasing, not all therapeutic modalities and techniques have been shown to be efficacious, and some have harmful adverse effects and are therefore not promoted in lieu of standard or evidence-based therapies. [73][74][75][76][77][78][79] For example, hyperbaric oxygen for the treatment of cerebral palsy has not been shown to be efficacious and is associated with harmful adverse effects and is therefore not recommended. 78,80,81 Similarly, evidence for the benefits of patterning is lacking.…”

Section: Therapeutic Benefitsmentioning

confidence: 99%

“…[73][74][75][76][77][78][79] For example, hyperbaric oxygen for the treatment of cerebral palsy has not been shown to be efficacious and is associated with harmful adverse effects and is therefore not recommended. 78,80,81 Similarly, evidence for the benefits of patterning is lacking. 81 Treatment success that is only supported by case reports or anecdotal data and not by carefully designed research studies warrants further investigation and discussion before prescribing.…”

Section: Therapeutic Benefitsmentioning

confidence: 99%

Prescribing Physical, Occupational, and Speech Therapy Services for Children With Disabilities

Houtrow

Murphy

2019

Pediatrics

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Pediatric health care providers are frequently responsible for prescribing physical, occupational, and speech therapies and monitoring therapeutic progress for children with temporary or permanent disabilities in their practices. This clinical report will provide pediatricians and other pediatric health care providers with information about how best to manage the therapeutic needs of their patients in the medical home by reviewing the International Classification of Functioning, Disability and Health; describing the general goals of habilitative and rehabilitative therapies; delineating the types, locations, and benefits of therapy services; and detailing how to write a therapy prescription and include therapists in the medical home neighborhood. Pediatricians and other pediatric health care providers have a vitally important role of linking children and youth with disabilities in their family-centered primary care medical homes with appropriate community-based services. 1 Pediatric providers are often asked (frequently by families) or recognize the need to prescribe habilitative and rehabilitative therapies (physical, occupational, and speech and language) for infants, children, and youth with disabilities in their clinical practices. Many general pediatric providers describe inadequate training to appropriately prescribe therapy in the various settings in which they may be available to children with disabilities. 2-5 This clinical report will review (1) the framework of the International Classification of Functioning, Disability and Health (ICF) for understanding the interaction between health conditions and personal and environmental factors that result in disability, (2) children with disabilities and the goals of habilitation and rehabilitation services, (3) the types of therapy services available with their general indications, (4) the locations in which children may receive therapy services and potential facilitators and barriers to securing therapy services, (5) the existing literature regarding the benefits of therapy and

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“…HBOT is also used as an adjuvant for several other conditions including burns, autism, crush injuries, and compartment syndromes. Professional sports teams have also favored the use of HBOT to speed injury ( Strauss et al, 1983 ; Strauss and Hart, 1984 ; Skyhar et al, 1986 ; Cianci and Sato, 1994 ; Goldfarb et al, 2016 ). Moreover, several studies have proposed that HBOT mobilizes stem cells by improving homing and subsequent engraftment in injured tissues, which would explain, in part, the therapeutic effects of HBOT ( Zádori et al, 2011 ; van Neck et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

“…Despite all of the evidence of HBOT’s positive effects, its clinical value is still yet under discussion (see Dulai et al, 2014 ; An et al, 2015 ; Fox et al, 2015 ; Goldfarb et al, 2016 ; Chong and Rice, 2016 ; Borab et al, 2017 ). One difficulty of assessing the positive effects of HBOT in both experimental and clinical use includes the lack of standardized treatment protocols.…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen Increases Stem Cell Proliferation, Angiogenesis and Wound-Healing Ability of WJ-MSCs in Diabetic Mice

et al. 2018

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Hyperbaric oxygen therapy (HBOT) is effective for the medical treatment of diverse diseases, infections, and tissue injury. In fact, in recent years there is growing evidence on the beneficial effect of HBOT on non-healing ischemic wounds. However, there is still yet discussion on how this treatment could benefit from combination with regenerative medicine strategies. Here we analyzed the effects of HBOT on three specific aspects of tissue growth, maintenance, and regeneration: (i) modulation of adult rodent (Mus musculus) intestinal stem cell turnover rates; (ii) angiogenesis dynamics during the development of the chorio-allantoic membrane (CAM) in Gallus gallus embryos; (iii) and wound-healing in a spontaneous type II diabetic mouse model with a low capacity to regenerate skin. To analyze these aspects of tissue growth, maintenance, and regeneration, we used HBOT alone or in combination with cellular therapy. Specifically, Wharton Jelly Mesenchymal Stem cells (WJ-MSC) were embedded in a commercial collagen-scaffold. HBOT did not affect the metabolic rate of adult mice nor of chicken embryos. Notwithstanding, HBOT modified the proliferation rate of stem cells in the mice small intestinal crypts, increased angiogenesis in the CAM, and improved wound-healing and tissue repair in diabetic mice. Moreover, our study demonstrates that combining stem cell therapy and HBOT has a collaborative effect on wound-healing. In summary, our data underscore the importance of oxygen tension as a regulator of stem cell biology and support the potential use of oxygenation in clinical treatments.

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Hyperbaric oxygen therapy for the treatment of children and youth with Autism Spectrum Disorders: An evidence-based systematic review

Cited by 9 publications

References 17 publications

Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology

Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology

Prescribing Physical, Occupational, and Speech Therapy Services for Children With Disabilities

Hyperbaric Oxygen Increases Stem Cell Proliferation, Angiogenesis and Wound-Healing Ability of WJ-MSCs in Diabetic Mice

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