Hyperbaric oxygen therapy improves spatial learning and memory in a rat model of chronic traumatic brain injury

Harch, Paul G.; Kriedt, Christopher; Meter, Keith W. Van; Sutherland, Robert J.

doi:10.1016/j.brainres.2007.06.105

Cited by 52 publications

(47 citation statements)

References 42 publications

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“…Pulmonary oxygen toxicity can occur with normobaric hyperoxia, but neurologic oxygen toxicity generally requires oxygen levels that can only be reached with hyperbaric hyperoxia. The neurological manifestations of hyperbaric O 2 toxicity include signs and symptoms ranging from anxiety, nausea, altered vision and hearing to muscular twitching, unconsciousness and convulsions [2]. The degree and latency of injury vary according to partial pressure of inspired oxygen.…”

Section: Introductionmentioning

confidence: 99%

Microarray Analysis of Gene Expression in Rat Cortical Neurons Exposed to Hyperbaric Air and Oxygen

et al. 2008

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To gain a global view of the genomic response of neurons to normobaric and hyperbaric hyperoxic stress, we performed a microarray analysis of gene expression after exposure to varying levels of partial oxygen pressures. Rat neurons were exposed to normobaric hyperoxia, hyperbaric (2, 4, and 6 atmosphere absolute) air or hyperbaric O(2). We identified 183 genes significantly altered (increased or decreased >or=1.5-fold) in response to pressure and/or oxidative stress. Among them, 17 genes changed in response to all exposure conditions. More genes were altered in response to hyperbaric air than hyperbaric O(2). The altered genes included factors associated with stress responses, transport/neurotransmission, signal transduction, and transcription factors. The results may serve as guidance for selection of biomarkers of hyperoxia and hyperbaric O(2) response and provide a starting point for further studies to investigate the global molecular mechanisms underlying hyperbaric oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Microarray Analysis of Gene Expression in Rat Cortical Neurons Exposed to Hyperbaric Air and Oxygen

et al. 2008

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“…This case report is the first application of the authors' low pressure HBOT protocol for chronic brain injury to blast-induced TBI/PCS and PTSD. An early version of this protocol was recently reported in an animal model of chronic TBI that duplicated the human experience [4]. …”

Section: Introductionmentioning

confidence: 99%

Low pressure hyperbaric oxygen therapy and SPECT brain imaging in the treatment of blast-induced chronic traumatic brain injury (post-concussion syndrome) and post traumatic stress disorder: a case report

et al. 2009

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A 25-year-old male military veteran presented with diagnoses of post concussion syndrome and post traumatic stress disorder three years after loss of consciousness from an explosion in combat. The patient underwent single photon emission computed tomography brain blood flow imaging before and after a block of thirty-nine 1.5 atmospheres absolute hyperbaric oxygen treatments. The patient experienced a permanent marked improvement in his post-concussive symptoms, physical exam findings, and brain blood flow. In addition, he experienced a complete resolution of post-traumatic stress disorder symptoms. After treatment he became and has remained employed for eight consecutive months. This case suggests a novel treatment for the combined diagnoses of blast-induced post-concussion syndrome and post-traumatic stress disorder.

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“…HBO limits the growth of cerebral contusions (13), increases the contused hippocampus vascular density (14), decreases the extent of secondary cell death and reactive neuroinflammation (15), preserves mitochondrial integrity and inhibits the mitochondrial apoptotic pathway (16). As an adjunctive treatment for patients with TBI, HBO may reduce the risk of mortality and improve the final Glasgow Coma Scale score (17).…”

Section: Introductionmentioning

confidence: 99%

Effect of hyperbaric oxygenation therapy on post‑concussion syndrome (Review)

Dong

et al. 2018

Exp Ther Med

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The present review evaluated the effect of hyperbaric oxygenation (HBO) therapy on post-concussion syndrome (PCS). Searches for publications from the earliest date possible up until the first week of 2016 were conducted using the electronic databases Cochrane, EBSCOhost, Embase, Ovid MEDLINE, PubMed and Web of Science. Additional trials were identified through reference list scanning. Randomized controlled trials assessing the effectiveness of HBO therapy in PCS were selected and tested for eligibility for inclusion in the present review. Two independent reviewers conducted data extraction and the Cochrane Collaboration's recommended method was used to assess the risk of bias in each study included. Review Manager 5.3 software was used for data synthesis and analysis and the standardized mean difference (SMD) or mean difference (MD) was estimated with a fixed or random effects model using a 95% confidence interval (CI). A total of 127 articles were identified, 4 of which were eligible for final analysis. The meta-analysis identified no difference in the Rivermead Post-Concussion Symptoms Questionnaire (MD=1.23; 95% CI, −3.47-5.94; P>0.05; I2=35%) or Post-Traumatic Stress Disorder Checklist (PCL) scores (SMD=0.12; 95% CI, −0.31-0.54; P>0.05; I2=0%) scores between groups receiving different oxygen doses. The differences in PCL scores (SMD=−0.13, 95% CI, −0.80-0.53; P>0.05; I2=63%) and neurobehavioral symptoms (SMD=−1.00, 95% CI, −2.58-0.58; P>0.05; I2=92%) between the HBO and sham groups were not significant. The current study demonstrated that HBO therapy has no significant effect on PCS compared with the sham group. Therefore, it was determined that effective design and execution of a large clinical trial, which includes treatment, control and sham groups is required in the future.

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Hyperbaric oxygen therapy improves spatial learning and memory in a rat model of chronic traumatic brain injury

Cited by 52 publications

References 42 publications

Microarray Analysis of Gene Expression in Rat Cortical Neurons Exposed to Hyperbaric Air and Oxygen

Microarray Analysis of Gene Expression in Rat Cortical Neurons Exposed to Hyperbaric Air and Oxygen

Low pressure hyperbaric oxygen therapy and SPECT brain imaging in the treatment of blast-induced chronic traumatic brain injury (post-concussion syndrome) and post traumatic stress disorder: a case report

Effect of hyperbaric oxygenation therapy on post‑concussion syndrome (Review)

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