Hyperbaric Oxygen Therapy in Orthopaedics: An Adjunct Therapy with an Emerging Role

Jeyaraman, Madhan; Sami, Abdus; Nallakumarasamy, Arulkumar; Jeyaraman, Naveen; Jain, Vijay Kumar

doi:10.1007/s43465-023-00837-2

Cited by 7 publications

(7 citation statements)

References 78 publications

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“…The smaller ALP value at T0 in the HBOT group compared to the HBOT + SURG group becomes a bias for the comparison of the values of this enzyme between these groups. Additionally, studies have reported variations in ALP activity caused by intestinal injury in rats [ 39 ] and greater osteoblast activity in humans undergoing HBOT [ 7 ]. However, no studies have evaluated the influence of HBOT on serum biochemistry in dogs.…”

Section: Discussionmentioning

confidence: 99%

“…HBOT has been recognized as one of the best adjuvant therapies for the healing of complicated wounds in veterinary [ 1 , 3 , 6 ] and human medicine [ 7 , 8 ]. Studies have shown that HBOT has applications in preconditioning for surgery in human patients, reducing the rates of postoperative complications and length of stay in the intensive care unit [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Hyperbaric Oxygen Therapy on Hemogram, Serum Biochemistry and Coagulation Parameters of Dogs Undergoing Elective Laparoscopic-Assisted Ovariohysterectomy

Antunes,

Caye,

Schiefler

et al. 2024

Animals

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Background: This study explored the effects of hyperbaric oxygen therapy (HBOT) on hemogram, serum biochemistry and hemostatic variables in female dogs undergoing laparoscopic-assisted ovariohysterectomy (OVH). Materials: Thirty adult, mixed-breed, healthy female dogs were randomly divided into the following three groups: HBOT + SURG (exposed to two absolute atmospheres (ATAs) for 45 min followed by laparoscopic-assisted OVH), HBOT (exposed to two ATAs for 45 min) and SURG (laparoscopic-assisted OVH). Blood samples were collected at T0 (at the admission), at T1, 24 h after T0 (immediately after HBOT in the HBOT + SURG and HBOT groups, and immediately before anesthetic premedication in the SURG group), and at T2, 48 h after T0 (24 h after HBOT and anesthetic premedication). Methods: Assessments included erythrogram, leukogram, thrombogram, renal and hepatic serum biochemistry, prothrombin time (PT), activated partial thromboplastin time (APTT), buccal mucosal bleeding time (BMBT) and bloodstain area (BA) on hygroscopic paper collected at the BMBT. Results: Both the HBOT + SURG and SURG groups presented neutrophilia (p ≤ 0.0039) at T2 and an increase of ALP at T2 (p ≤ 0.0493), the SURG group presented an increase in leukocyte count at T2 (p = 0.0238) and the HBOT + SURG group presented a reduction in lymphocyte count at T2 (p = 0.0115). In the HBOT + SURG group, there was a reduction in PT and APTT in relation to the baseline value (p ≤ 0.0412). Conclusions: A session of HBOT at two ATAs for 45 min did not cause changes in the BMBT or BA in healthy female dogs. Some blood parameters investigated (neutrophil and lymphocyte count, ALP, PT and APTT) were affected by the use of HBOT.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Hyperbaric Oxygen Therapy on Hemogram, Serum Biochemistry and Coagulation Parameters of Dogs Undergoing Elective Laparoscopic-Assisted Ovariohysterectomy

Antunes,

Caye,

Schiefler

et al. 2024

Animals

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“…On the other hand, estrogen de ciency can also affect intestinal mucosal barrier permeability, leading to bacterial translocation and altered gut microbiota diversity. This can then affect various bone properties by modulating the gut-bone axis [31,34,35] . The gut mucosal barrier is a physical and biochemical barrier that lines the gut wall and protects the body from harmful substances and microorganisms.…”

Section: Discussionmentioning

confidence: 99%

Study on the trend of changes in the gut microbiota of rats with ovariectomy-induced postmenopausal osteoporosis and the effect of estrogen intervention

lei,

Cheng,

Xia

et al. 2023

Preprint

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Postmenopausal osteoporosis (PMOP) is a common primary osteoporosis. With the aging of the population, it is becoming a major disease that endangers health and quality of life. The purpose of this study was to explore the effect of gut microbiota on PMOP by observing the changes in the levels of estradiol, bone density, and gut microbiota diversity in rats after 3 months of OVX surgery. We randomly divided 60 female SD rats into four groups: baseline group (6 rats), sham-operated group (18 rats), model group (18 rats), and estrogen-treated group (18 rats). The ovariectomy model of postmenopausal osteoporosis was established by performing bilateral ovariectomy. After surgery, 6 rats from each group were randomly sacrificed every 30 days and assessed. After 90 days, all rats were sacrificed and their body weight, bone mineral density (BMD), tissue mineral density (TMD), trabecular bone parameters, femoral bone morphology, hormone levels, and gut microbiota diversity were assessed. We found that OVX led to a decrease in BMD, TMD, and serum estradiol levels in rats, and Increases TNF-α levels. The bone micro-architecture and tissue morphology were also changed, with trabecular fractures, thinning, and decreased numbers. The gut microbiota diversity also changed. Estrogen treatment could improve these changes. OVX leads to a sustained decrease in estrogen levels in rats, which results in progressive bone loss. This is associated with an imbalance in the gut microbiota.

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“…However, the potential benefits of RF sensing technology in detecting bone fractures make it a worthwhile endeavour. By overcoming these challenges, we can pave the way for this technology to become an integral part of clinical practice, significantly improving patient outcomes and advancing the field of bone health diagnostics [83].…”

Section: Annals Of Reviews and Researchmentioning

confidence: 99%

"Exploring Radio Frequency Techniques for Bone Fracture Detection: A Comprehensive Review of Low Frequency and Microwave Approaches"

Abd- Alhameed

2023

ARR

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This comprehensive review paper examines bone fracture detection techniques based on time-domain low-frequency and microwave radiofrequency (RF). Early and accurate diagnosis of bone fractures remains critical in healthcare, as it can significantly improve patient outcomes. This review focuses on the potential of low-frequency and microwave RF methods, particularly their combination and application of time-domain analysis for enhanced fracture detection. We begin by providing an overview of the fundamental concepts of RF techniques and then by examining biological tissues' dielectric properties. We then compare the advantages and limitations of various bone fracture detection techniques, such as low-frequency RF methods, microwave RF methods, ultrasonography, X-ray, and CT scan. The discussion then shifts to hybrid approaches that combine low-frequency and microwave techniques, emphasising the advantages of such combinations in fracture detection. Machine learning techniques, their applications in bone fracture detection, and the role of time-domain analysis in hybrid approaches are also investigated. Finally, we examine the accuracy and reliability of simulated models for bone fracture detection. We finish with a discussion on recent advancements and future directions, such as novel sensor technologies, improved signal processing techniques, integration with medical imaging modalities, and personalised fracture detection approaches. This review aims to comprehensively understand the landscape and future potential of time-domain analysis in low-frequency and microwave RF techniques for bone fracture detection.

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Hyperbaric Oxygen Therapy in Orthopaedics: An Adjunct Therapy with an Emerging Role

Cited by 7 publications

References 78 publications

Effects of Hyperbaric Oxygen Therapy on Hemogram, Serum Biochemistry and Coagulation Parameters of Dogs Undergoing Elective Laparoscopic-Assisted Ovariohysterectomy

Effects of Hyperbaric Oxygen Therapy on Hemogram, Serum Biochemistry and Coagulation Parameters of Dogs Undergoing Elective Laparoscopic-Assisted Ovariohysterectomy

Study on the trend of changes in the gut microbiota of rats with ovariectomy-induced postmenopausal osteoporosis and the effect of estrogen intervention

"Exploring Radio Frequency Techniques for Bone Fracture Detection: A Comprehensive Review of Low Frequency and Microwave Approaches"

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