Hyperbaric Oxygen Therapy Is Associated With Lower Short- and Long-Term Mortality in Patients With Carbon Monoxide Poisoning

Huang, Chun‐Yen; Ho, Chung Han; Chen, Yi‐Chen; Lin, Hung Jung; Hsu, Chien Chin; Wang, Jhi Joung; Su, Shih Bin; Guo, How‐Ran

doi:10.1016/j.chest.2017.03.049

Cited by 79 publications

(56 citation statements)

References 12 publications

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“…Majority of medical indications of HBO therapy is related to improved oxygen delivery to tissues caused by increased quantity of oxygen dissolved in plasma. HBO therapy is widely recommended in the treatment of chronic and acute non-healing wounds and ulcers (Brem and Tomic-Canic et al 2017), necrotizing soft tissue infections (Wilkinson and Doolette 2004), spinal cord injury (Patel and Huang 2017), and carbon monoxide poisoning (Huang et al 2017). Although beneficial effects of HBO have been documented in a number of double-blind controlled randomized studies, meta-analyses of trials focused on individual indications questioned their design, analysis, and conclusions pointing out the increased risk of bias and methodological flaws (Bennett et al 2012, Buckley et al 2011, Yang et al 2015.…”

Section: Introductionmentioning

confidence: 99%

Repeated Exposure to Hyperbaric Hyperoxia Affects Mitochondrial Functions of the Lung Fibroblasts

Dejmek

Kohoutová²,

Kripnerová³

et al. 2018

Physiol Res

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Hyperbaric oxygen (HBO) therapy, i.e. breathing pure oxygen under increased environmental pressures serves as a treatment for diverse medical conditions. However, elevated oxygen concentration can be detrimental to central nervous system or lungs. Our study aimed to evaluate the effects of repeated exposure to HBO on mitochondrial respiration assessed by high-resolution respirometry (HRR), cell viability estimated by PrestoBlue® reaction, morphology analyzed by routine phase contrast and fluorescent microscopy, and superoxide dismutase (SOD) and citrate synthase (CS) activities using human lung fibroblasts. The cells were exposed to HBO for 2 h per day for 5 consecutive days. One day after the last exposure, HBO cells displayed significantly smaller area and perimeter, compromised viability and elevated SOD activity. No changes were detected in CS activity or quality of mitochondrial network. HRR revealed impaired mitochondrial oxygen consumption manifested by increased leak respiration, decreased activity of complex II and compromised ATP-related oxygen consumption when fatty acids were oxidized. Our findings document that in conditions mimicking chronic intermittent exposure to HBO, lung fibroblasts suffer from compromised mitochondrial respiration linked to complex II and impaired cellular growth in spite of increased antioxidant defense. Underlying mechanism of this HBO-induced mitochondrial dysfunction should be further explored.

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Section: Introductionmentioning

confidence: 99%

Repeated Exposure to Hyperbaric Hyperoxia Affects Mitochondrial Functions of the Lung Fibroblasts

Dejmek

Kohoutová²,

Kripnerová³

et al. 2018

Physiol Res

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“…Hyperbaric Oxygen (HBO) treatment significantly reduces the half-life of carboxyhemoglobin [33]. Several evidences have showed the benefits from hyperbaric-oxygen therapy on memory [34,35], delayed neuropsychological sequelae [36,37] and lowing mortality [38], but evidences supporting the use of hyperbaric oxygen in patients with CO poisoning come from randomized trials with significant limitations and observational studies. So identifying patients who will benefit from HBO treatment remains uncertain.…”

Section: Discussionmentioning

confidence: 99%

Increased long-term risk of dementia in patients with carbon monoxide poisoning: A systematic review and meta-analysis of cohort studies

Zhang¹,

Wei²,

Chien³

et al. 2019

Preprint

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Background It has long been known that carbon monoxide poisoning is associated with cognitive dysfunction but whether carbon monoxide poisoning is a risk factor for incident dementia is still inconclusive. Our objective was to assess whether carbon monoxide poisoning increases the incidence of dementia. Methods We conducted a systematic review and meta analysis of cohort studies examining the risk of dementia in people with carbon monoxide poisoning. We searched the Cochrane Library, PubMed, and EMBASE from inception to 31 March 2019. Two authors independently selected studies, assessed the quality of included studies, and extracted data. Any disagreement was resolved by discussion with a third author. Only cohort study with an enough follow-up period was included, which reported the association between carbon monoxide poisoning and incidence of dementia in adults. Exposure was carbon monoxide poisoning; primary outcomes were incident all-cause dementia, Alzheimer’s disease and cognitive disorder. Summary estimates were obtained using random effects meta-analysis. Results Thirty-three full texts were initially searched, but only three studies met our inclusion criteria, and they were comprised of 134,563 participants who were initially free of dementia. The follow-up period ranged from 9 to 12 years. We found that CO poisoning increased the risk of dementia incidence [adjusted hazard ratio 2.61, 95% confidence interval (CI) 1.56 to 4.36, P = 0.0003]. Subgroup analysis showed that the increased dementia risk was significant in males but not in females, and the highest risk was in young age group, followed by in middle age group, but not in the old one (P > 0.05). Conclusions This meta-analysis suggests that overall the evidence from prospective cohort studies supported a link between carbon monoxide exposure and an increased dementia risk, although all the included studies were limited to Taiwanese population. Further studies that provide data for different ethnic groups are needed to clarify whether a subgroup of patients with carbon monoxide exposure has an elevated risk of dementia.

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“…There is a clear predominance of deaths through acute poisoning with carbon monoxide, a significant cause of home death, mostly accidental, reported as most prevalent also in studies conducted in other countries [12][13][14][15][16] . Among the multidrug poisonings, we observed that most of them occurred in the age group of 12-18 years, with serious drug intoxication, the most commonly involved substances being anti-inflammatory and analgesic drugs, oral antidiabetics, tricyclic antidepressants, benzodiazepines and barbiturates.…”

Section: Etiologymentioning

confidence: 99%

Nephrotoxic injury in fatal poisonings in children - etiology and pathological aspects

Ulmeanu¹,

Boghiţoiu²,

Ulmeanu³

et al. 2019

Arch Balk Med Union

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Etiologie et aspects pathologiques des lésions néphrotoxiques dans les intoxications mortelles chez les enfants Introduction. La prévalence réelle des néphropathies toxiques chez les enfants n'est pas complètement connue car les modifications fonctionnelles et structurelles de la fonction rénale causées par les néphrotoxines ne sont pas spécifiques. L'objectif de l'étude était d'évaluer l'étiologie et l'implication rénale dans les intoxications graves au potentiel létal. Méthodes. Nous avons analysé rétrospectivement l'étiologie des décès par empoisonnement chez les enfants au cours d'une période de 9 ans, l'étiologie et la fréquence des lésions néphrotoxiques et les aspects pathologiques des empoisonnements néphrotoxiques. Résultats. Sur un total de 69 décès d'enfants dus à une intoxication aiguë, la cause la plus fréquente de décès était une intoxication aiguë au monoxyde de carbone, soit 23 cas. Les autres étiologies: intoxication par plusieurs drogues-9 cas , intoxications aux organophosphorés-9 cas et intoxications par des drogues illicites-8 cas. Des lésions rénales aiguës étaient

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Hyperbaric Oxygen Therapy Is Associated With Lower Short- and Long-Term Mortality in Patients With Carbon Monoxide Poisoning

Cited by 79 publications

References 12 publications

Repeated Exposure to Hyperbaric Hyperoxia Affects Mitochondrial Functions of the Lung Fibroblasts

Repeated Exposure to Hyperbaric Hyperoxia Affects Mitochondrial Functions of the Lung Fibroblasts

Increased long-term risk of dementia in patients with carbon monoxide poisoning: A systematic review and meta-analysis of cohort studies

Nephrotoxic injury in fatal poisonings in children - etiology and pathological aspects

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