Hyperbaric oxygen therapy prevents coagulation disorders in an experimental model of multiple organ failure syndrome

Imperatore, Francesco; Cuzzocrea, Salvatore; Lucia, Domenico De; Sessa, Marcella; Rinaldi, Barbara; Capuano, Annalisa; Liguori, Giovanni; Filippelli, Amelia; Rossi, Francesco

doi:10.1007/s00134-006-0367-3

Cited by 16 publications

(14 citation statements)

References 38 publications

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“…Our results confirm the point of view, that early HBOT application in MI patients, results in faster eradication of misbalanced oxygen myocardial need and delivery, which contributes to MI area reduction, scar healing with "softer" collagen tissue, aneurysm prevention [28,35]. It has been demonstrated in an experimental condition that the influence of hyperbaric oxygenation prevents the development of hypercoagulation syndrome [36], HBOT application immediately after coronary occlusion reduces myocardial necrosis and acute mortality in rats [37]. The beneficial effects of HBOT in treating ischemia-related wounds may be mediated by stimulating angiogenesis [27].…”

Section: Discussionsupporting

confidence: 87%

Influence of hyperbaric oxygenation treatment (HBOT) on clinical outcomes (recurrent myocardial infarction and survival rate) during five-year monitoring period after acute myocardial infarction

Доценко¹,

Salivonchyk²,

Welcome³

et al. 2014

Health

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Surgical treatments of acute myocardial infarction (MI) possess a high clinical effectiveness, but there are fixed limitations, related to the patient's state, which are limited by medical resources and organizational problems. The development of new medical technologies provides a better and effective non-surgical treatment of acute MI and increases long-term prognosis in this category of patients. The study aims to investigate the influence of hyperbaric oxygenation treatment on clinical outcomes (survival rate and recurrent myocardial infarction (rMI)) during the five-year period of monitoring. The study involved 697 patients who suffered from acute MI, having undergone the standard treatment. The patients were randomly divided into two groups: Group 1 (reference, n = 363); Group 2 (test, n = 334). Patients of Group 2 were given the traditional treatment, accompanied with HBOT (isopression for forty minutes at a working pressure of 0.03 MPa). HBOT was applied first through the fifth day following MI. The treatment course included six cycles, once per day. The clinical assessment was focused on clinical outcome: rMI and mortality related to cardiovascular events. HBOT application that accompanied the acute MI with traditional pharmacotherapy has been proved to reduce rMI within five years following inpatient discharge (rMI rate was 14% in the reference group and 5.4% in the test group, χ 2 = 13.3, р < 0.05). The combination of HBOT with traditional methods in treating acute MI makes it possible to raise the five-year survival rate from 84.4% up to 95.9%.

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Section: Discussionsupporting

confidence: 87%

Influence of hyperbaric oxygenation treatment (HBOT) on clinical outcomes (recurrent myocardial infarction and survival rate) during five-year monitoring period after acute myocardial infarction

Доценко¹,

Salivonchyk²,

Welcome³

et al. 2014

Health

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“…A correlation between a portal hypertensive effect and a decrease in systemic arterial pressure in intact animals was indeed demonstrated by Shibamoto et al [38] and Kaufman and Levasseur [15]. These observations support the hypothesis that the liver hemodynamic changes could contribute, partly at least, to the systemic pressure reduction observed in the zymosaninduced multiple-organ failure syndrome [13].…”

Section: Discussionmentioning

confidence: 63%

“…As the uptaking of gluconeogenic substrates from the circulation seems to be also reduced [18], the role of the liver in the maintenance of glycemia in the fasted condition could be also compromised. These metabolic consequences of the zymosanvascular changes along with the possible consequences for the macrohemodynamics of the intact animals may contribute to the development of the zymosan-induced multiple organ failure syndrome [13].…”

Section: Discussionmentioning

confidence: 99%

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The action of zymosan on octanoate transport and metabolism in the isolated perfused rat liver

Derbocio

López

Bracht

et al. 2009

J Biochem & Molecular Tox

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The effects of zymosan on transport, distribution, and metabolism of octanoate in the perfused rat liver were investigated using the multiple-indicator dilution technique. Livers were perfused with 300 microM octanoate in the absence or in the presence of 100 microg/mL zymosan. Tracer amounts of [1-14C]octanoate, [3H] water, and [131I]albumin were injected into the portal vein, and the effluent perfusate was fractionated. The normalized dilution curves were analyzed by means of a space-distributed variable transit time model. Zymosan decreased the space into which octanoate undergoes flow-limited distribution, possibly the first cellular exchanging pool represented by plasma membranes and their adjacencies. However, the rate of transfer of octanoate from the plasma membrane into the rest of the cell was not modified as indicated by the similar values of the influx rates and also the net uptake of octanoate per unit of accessible cellular volume. However, when referred to the wet weight of the liver, the net uptake of octanoate was 37.5% reduced, a value corresponding to the diminution of the cellular accessible space. It can be concluded that an exclusion of a fraction of the liver parenchyma from the microcirculation is the main mechanism by which zymosan reduces the metabolism of exogenous octanoate.

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“…Imperatore and colleagues have previously demonstrated that intermittent hyperbaric oxygen (HBO) therapy is effective in attenuating this process in a zymosan-induced MOFS model in rats. They have now published a further study concentrating on the effects of HBO on the coagulation cascade [ 3 ]. The zymosan insult produced a marked coagulopathy, MOFS and a 50% mortality at 72 hours in the control group.…”

Section: Confused By Oxygen?mentioning

confidence: 99%

Untitled

Ball

2007

Crit Care

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This issue's recently published papers commentary takes a long hard look at the surprisingly topically issue of oxygen. To give a balanced perspective, topical ventilatory studies are also discussed. Confused by oxygen?Several recently published papers have demonstrated both the pros and cons of oxygen therapy. They also serve to illustrate that extrapolating from studies with experimental animal models to the clinical arena requires great caution.In a rat model of haemorrhagic shock, Brod and colleagues investigated the effects of combined resuscitation with hypertonic saline and oxygen [1]. The authors designed a complex protocol with sequential single interventions and compared 5 ml/kg fluid resuscitation using 0.9% and 7.5% saline and a fraction of inspired oxygen (FiO 2 ) of 0.21 and 1.0. They measured regional perfusion in several vascular beds together with plasma lactate as a measure of the adequacy of resuscitation. Their results showed that 7.5% saline and 100% oxygen was the superior strategy. Of particular note were the marked haemodynamic effects of increasing the FiO 2 to 1.0. The accompanying editorial [2] considers these results in a wider clinical context. It rightly concludes that the effects of 100% oxygen on regional blood flow, and hence its role in resuscitation, have for too long been neglected and warrant further investigation.Multiple organ failure syndrome (MOFS) is the final common pathway of critical illness. Imperatore and colleagues have previously demonstrated that intermittent hyperbaric oxygen (HBO) therapy is effective in attenuating this process in a zymosan-induced MOFS model in rats. They have now published a further study concentrating on the effects of HBO on the coagulation cascade [3]. The zymosan insult produced a marked coagulopathy, MOFS and a 50% mortality at 72 hours in the control group. The intervention group, which was subjected to two 60-minute periods of hyperbaric (2 atmospheres absolute (ATA) oxygen (FiO 2 1.0) at 4 and 11 hours after MOFS initiation, demonstrated a markedly attenuated coagulopathy with less severe MOFS and a 100% survival at 72 hours.In a related study, Buras and colleagues investigated the efficacy of four oxygen regimens in a caecal ligation-andpuncture model of MOFS in mice [4]. In addition to survival, they measured bacterial load and performed experiments on macrophage function, specifically investigating whether IL-10 has a key role in the protective effect of HBO therapy. In comparison with the control group, which received an FiO 2 of 0.21, normobaric FiO 2 of 1.0 for 90 minutes at 12-hourly intervals and HBO at 2.5 ATA for 90 minutes at 24-hourly intervals had no effect on survival at 100 hours (mortality 80%). HBO at 2.5 ATA for 90 minutes at 12-hourly intervals improved survival from 20% to 70%. HBO at 3 ATA for 90 minutes at 12-hourly intervals proved be 100% lethal after approximately 30 hours. The successful strategy did not reduce the bacterial load in the peritoneum but did reduce the load disseminated to the spleen, s...

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Hyperbaric oxygen therapy prevents coagulation disorders in an experimental model of multiple organ failure syndrome

Abstract: The hypercoagulability induced by zymosan could be responsible for organ failure and death. Our data demonstrate that HBO therapy significantly prevents the alteration in the coagulation cascade and arterial blood gas in an experimental model of MOFS.

Cited by 16 publications

References 38 publications

Influence of hyperbaric oxygenation treatment (HBOT) on clinical outcomes (recurrent myocardial infarction and survival rate) during five-year monitoring period after acute myocardial infarction

Influence of hyperbaric oxygenation treatment (HBOT) on clinical outcomes (recurrent myocardial infarction and survival rate) during five-year monitoring period after acute myocardial infarction

The action of zymosan on octanoate transport and metabolism in the isolated perfused rat liver

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