Hyperbaric Oxygen Therapy: Ten Common Questions Related to the Management of Severe Necrotizing Skin and Soft-Tissue Infections

Wu, Wenchao; Lieber, M

doi:10.1097/00019048-200111000-00005

Cited by 3 publications

(5 citation statements)

References 30 publications

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“…Its use has been based upon potential mechanisms of benefit supported by case reports and retrospective reviews 11−15 . Most retrospective clinical studies suggest that the use of HBO in the treatment of severe necrotizing soft‐tissue infection is associated with lower mortality rate 16 . Riseman found HBO use to be associated with significantly reduced mortality: 66% versus 23% 12 .…”

Section: Discussionmentioning

confidence: 99%

The hospital costs of treating necrotizing fasciitis

Widjaja

Tran

Cleland

et al. 2005

ANZ Journal of Surgery

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Section: Discussionmentioning

confidence: 99%

The hospital costs of treating necrotizing fasciitis

Widjaja

Tran

Cleland

et al. 2005

ANZ Journal of Surgery

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“…41 The existing literature regarding the administration of high-dose IVIG in necrotizing fasciitis indicates that IVIG therapy may be beneficial in some patients when administered appropriately and in combination with a corticosteroid and an antihistamine. 39,45 To our knowledge, the patient did receive adequate supportive therapy based on his clinical signs and symptoms. Though HBO was considered in the case presentation, this therapy was deemed unnecessary by the HBO service because the wounds were granulating well.…”

Section: Discussionmentioning

confidence: 98%

“…For further information, a concise but informative review of HBO use in selected infections has been published recently. 39 The use of high-dose IVIG has been advocated as part of the initial therapy of necrotizing fasciitis, and preliminary data suggest a potential benefit of this ther-apy. 40 The rationale for using IVIG involves inhibiting T-cell activation, reversing T-cell proliferation, neutralizing superantigens, and down-regulating TNF production.…”

Section: Treatment Of Necrotizing Fasciitismentioning

confidence: 99%

Necrotizing Fasciitis Caused by Group A Streptococcus: Case Report and Therapy Update

Larose-Pierre

Scrivens

Norwood

et al. 2002

Journal of Pharmacy Practice

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Necrotizing fasciitis is a life-threatening infection that affects the fascia and fat tissue underlying the skin. The diagnosis is often difficult because subcutaneous changes may not be readily apparent. Toxin-producing bacteria are usually the cause, with group A streptococcus (GAS) or Streptococcus pyogenes being responsible for a significant portion of the morbidity and mortality associated with this infection. The mortality rate associated with necrotizing fasciitis varies between 30% and 60%. Toxic shock-like syndrome and multisystem organ failure are the usual causes of death. Early diagnosis and surgery have been associated with decreased morbidity and mortality, and appropriate antimicrobial (eg, penicillin plus clindamycin) and supportive therapy is of utmost importance. Intravenous immunoglobulin and hyperbaric oxygen therapy may be beneficial in treating the infection; however, these 2 therapies require further research. Clinicians need to familiarize themselves with the disease and the different treatment modalities to be able to make the appropriate therapeutic decision. The optimal treatment of necrotizing fasciitis still remains a challenge today. This article presents an illustrative case with a brief overview of necrotizing fasciitis, and the current therapeutic modalities used in the management of the disease.

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“…Necrotizing soft-tissue infections are an approved indication for hyperbaric oxygen therapy by the Undersea and Hyperbaric Medical Society, although there has been no prospective, randomized trial to verify the effectiveness of this use. 22,23 Hyperbaric oxygen therapy inhibits the growth of anaerobic bacteria and improves bacterial killing by polymorphonuclear leukocytes. 22 Kalani et al 24 reported a series of 38 diabetic patients who underwent hyperbaric oxygen therapy for diabetic foot ulcers.…”

Section: Discussionmentioning

confidence: 99%

“…22,23 Hyperbaric oxygen therapy inhibits the growth of anaerobic bacteria and improves bacterial killing by polymorphonuclear leukocytes. 22 Kalani et al 24 reported a series of 38 diabetic patients who underwent hyperbaric oxygen therapy for diabetic foot ulcers. In a prospective fashion, 17 patients underwent hyperbaric oxygen therapy daily, while 21 patients underwent conventional therapy.…”

Section: Discussionmentioning

confidence: 99%