Hyperbaric Oxygen Treatment in Radiation-Induced Cystitis and Proctitis: A Prospective Cohort Study on Patient-Perceived Quality of Recovery

Oscarsson, Nicklas; Arnell, Per; Lodding, Pär; Ricksten, Sven‐Erik; Seeman-Lodding, H.

doi:10.1016/j.ijrobp.2013.07.039

Cited by 64 publications

(52 citation statements)

References 16 publications

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“…The validity of the long-term findings, given the unblinded crossover of the control arm, has been questioned (124). Oscarsson et al (125) prospectively studied the effect of HBOT at 2.0e2.4 ATA in 39 patients with radiation cystitis and/or proctitis and evaluated EPIC scores at 6 and 12 months. Twentyseven patients had EPIC scores !80 at baseline and experienced a 39% increase in the bowel domain score 6e12 months after HBOT.…”

Section: Hyperbaric Oxygen Therapymentioning

confidence: 99%

Late rectal toxicity after low-dose-rate brachytherapy: Incidence, predictors, and management of side effects

Kishan

Kupelian

2015

Brachytherapy

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Section: Hyperbaric Oxygen Therapymentioning

confidence: 99%

Late rectal toxicity after low-dose-rate brachytherapy: Incidence, predictors, and management of side effects

Kishan

Kupelian

2015

Brachytherapy

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“…Especially, as far as radiation-induced haemorrhagic cystitis is concerned, several series of patients treated with HBO have been published (6, 8, 10-17, 21, 25-30). The vast majority are retrospective reviews and case series with only a few ones (6, 17, 26, present study) being prospective in nature. Furthermore, a recent review raised concerns on whether HBO therapy shows clear clinical benefit on radiation cystitis (25).…”

Section: Discussionmentioning

confidence: 99%

Hyberbaric oxygen as sole treatment for severe radiation - induced haemorrhagic cystitis

et al. 2017

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Purpose To examine the safety and efficacy of hyperbaric oxygen as the primary and sole treatment for severe radiation-induced haemorrhagic cystitis.Materials and methods Hyperbaric oxygen was prospectively applied as primary treatment in 38 patients with severe radiation cystitis. Our primary endpoint was the incidence of complete and partial response to treatment, while the secondary endpoints included the duration of response, the correlation of treatment success-rate to the interval between the onset of haematuria and initiation of therapy, blood transfusion need and total radiation dose, the number of sessions to success, the avoidance of surgery and the overall survival.Results All patients completed therapy without complications with a mean follow-up of 29.33 months. Median number of sessions needed was 33. Complete and partial response rate was 86.8% and 13.2%, respectively. All 33 patients with complete response received therapy within 6 months of the haematuria onset. One patient needed cystectomy, while 33 patients were alive at the end of follow-up.Conclusions Our study suggests the early primary use of hyperbaric oxygen for radiation-induced severe cystitis as an effective and safe treatment option.

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“…However, the side effects of formalin application include anal stenosis, fissures, fecal incontinence and ulceration of the mucosa; therefore, it was not a good choice for ulcerative CRP (32,33). Furthermore, although HBOT is reported to be an effective treatment for CRP, it is not widely applicable due to its high cost and the specialized equipment required (34,35). Finally, surgery is thought to be the last resort for CRP because of its severe postoperative complications.…”

Section: Discussionmentioning

confidence: 99%

Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis

Guan

Yao

et al. 2018

Exp Ther Med

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The aim of the present study was to investigate the safety and efficacy of mesalazine suppository in the treatment of refractory ulcerative chronic radiation proctitis (CRP). In total, 10 refractory ulcerative CRP patients who did not respond to previous medical treatments were recruited for the present study and were treated with mesalazine suppository (0.5 g) twice daily for 24 weeks. For each patient, the severity of clinical symptoms and endoscopic appearance was assessed before and after the treatment. For symptom scoring, the reductions in the mean total symptom score (pre- vs. post-treatment, 8.20 vs. 0.90; P<0.01), rectal bleeding score (2.40 vs. 0.30; P<0.01), rectal pain score (2.00 vs. 0.50; P<0.01), stool frequency score (2.00 vs. 0.10; P<0.01) and tenesmus score (1.80 vs. 0.00; P<0.01) were all statistically significant. For mucosal damage scoring, there was a reduction in the mean scores for total scores (9.22 vs. 5.22; P<0.01), telangiectasia (2.78 vs. 1.89; P=0.009), edema (2.89 vs. 1.78; P=0.001) and ulceration (2.44 vs. 0.89; P=0.003). However, statistically reductions in the median symptom scores were not observed for stenosis (0.78 vs. 0.67; P=0.347) and necrosis (0.33 vs. 0.00; P=0.081). Furthermore, no adverse events were observed during and after the treatment. The topical mesalazine suppository may be a safe and effective treatment for CRP, particularly for patients with deep ulcers. Adequately randomized controlled trials are required to confirm the results of the present study.

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Hyperbaric Oxygen Treatment in Radiation-Induced Cystitis and Proctitis: A Prospective Cohort Study on Patient-Perceived Quality of Recovery

Cited by 64 publications

References 16 publications

Late rectal toxicity after low-dose-rate brachytherapy: Incidence, predictors, and management of side effects

Late rectal toxicity after low-dose-rate brachytherapy: Incidence, predictors, and management of side effects

Hyberbaric oxygen as sole treatment for severe radiation - induced haemorrhagic cystitis

Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis

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