Hyperbasophilic immunoblasts in circulating blood in chronic inflammatory rheumatic and collagen diseases.

Delbarre, F; Go, Alabi; Kahan, A

doi:10.1136/ard.34.5.422

Cited by 32 publications

(14 citation statements)

References 27 publications

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“…Delbarre et al [18] have also noted an increase in the lymphoid cells of high nuclear-cytoplasmic ratio (hyperbasophilic immunoblasts) in the blood of patients with SLE.…”

Section: Wbcmentioning

confidence: 99%

Haematological Aspects of Systemic Lupus Erythematosus: A Reappraisal Using Automated Methods

Isenberg¹,

Patterson²,

Todd-Pokropek³

et al. 1982

Acta Haematol

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Twenty-two haematological parameters were measured in 30 patients with systemic lupus erythematosus (SLE) at 110 patient attendances. Using a 10,000 cells per sample automated differential counter, the major abnormalities demonstrated were: lympho-penia, monocytopenia, eosinophilopenia (each of which showed strong correlation with steroid therapy) and increased numbers of cells of high peroxidase activity. Despite the common lymphocytopenia elevation of large unstained cells was noted in 20% of patients. There was no correlation between disease activity and any single laboratory measurement. However, no patient with severe disease had a lymphocyte count above 1.9 × 10⁹/1 or a haemoglobin above 11.7 g/dl.

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“…Delbarre et al [18] have also noted an increase in the lymphoid cells of high nuclear-cytoplasmic ratio (hyperbasophilic immunoblasts) in the blood of patients with SLE.…”

Section: Wbcmentioning

confidence: 99%

Haematological Aspects of Systemic Lupus Erythematosus: A Reappraisal Using Automated Methods

Isenberg¹,

Patterson²,

Todd-Pokropek³

et al. 1982

Acta Haematol

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“…The immune system of patients with active SLE is characterized by generalized B-cell hyperactivity (3)(4)(5)(6)(7) and impaired T-cell function (8)(9)(10)(11)(12)(13)(14). The latter may result, at least in part, from a reduction in numbers of T lymphocytes (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Studies of immune functions of patients with systemic lupus erythematosus. T-cell subsets and antibodies to T-cell subsets.

Sakane¹,

Steinberg²,

Reeves³

et al. 1979

J. Clin. Invest.

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“…Certain studies bearing upon this important question support the concept that autoimmune phenomena and humoral hyperactivity in this disorder are a consequence of dysfunctional or numerically deficient suppressor T cells (32)(33)(34). Other work suggests that alternative mechanisms may be present, i.e., excess T help or a defect at the level of the B cell itself (27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 89%

“…The observation is consistent with in vitro studies showing conversion of null cells, termed "immature T cells," to E-RFC by incubation with thymosin (25). Other data, however, suggest that null cells in SLE may be B cell precursors (26) or even B cells already activated toward antibody production (27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Tγ cells in systemic lupus erythematosus

Hamilton

Winfield

1979

Arthritis & Rheumatism

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Circulating T cells bearing receptors for the Fc portion of IgC (T,) were identified by sensitive immunofluorescent techniques with rabbit IgG b4 allotype/antib4 complexes. A twofold decrease in both proportion and absolute number of T, cells was found in patients with active systemic lupus erythematosus (SLE) relative to values obtained during disease remission. The reduction in T, cells was most evident in patients with severe hypocomplementemia. A deficit of T, cells in active patients was not demonstrated. that was not apparent in regression analyses performed against other lymphocyte subpopulations. Such differences were not found for B cells and IgC receptor-bearing non-B/nod-T cells which were present in normal proportions in virtually all patients. The origin and functional significance of these unusual lymphocyte subpopulation abnormalities are discussed.A prominent area encompassing recent investigation into the bases for disordered immune regulation in systemic lupus erythematosus is the descriptive study of lymphocytes in peripheral blood using various surface marker techniques. It has been assumed that information of this nature will reflect functional immunologic abnormalities in the disease. Until very recently, unrecognized interference by factors carried over from patient plasma during lymphocyte isolation, and the limited capacity of marker techniques to resolve functionally discrete lymphocyte subpopulations have impeded progress toward this goal.The objective of the present study is to define further the nature of T lymphopenia in SLE. Antecedents include: 1) recognition that a T cell subset with receptors for the Fc portion of IgG (T,) may play a role in negative regulation of the immune response (l), and 2) development in this laboratory of a sensitive immunofluorescent technique for identification and quantitation of such cells using rabbit IgG b4/anti-b4 complexes (2).

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Hyperbasophilic immunoblasts in circulating blood in chronic inflammatory rheumatic and collagen diseases.

Cited by 32 publications

References 27 publications

Haematological Aspects of Systemic Lupus Erythematosus: A Reappraisal Using Automated Methods

Haematological Aspects of Systemic Lupus Erythematosus: A Reappraisal Using Automated Methods

Studies of immune functions of patients with systemic lupus erythematosus. T-cell subsets and antibodies to T-cell subsets.

Tγ cells in systemic lupus erythematosus

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