Hyperbilirubinemia and Hyponatremia as Predictors of Complicated Appendicitis

Shuaib, Abdullah; Alhamdan, Nour; Arian, Husain; Sallam, Mohamed Alaa; Shuaib, Ali

doi:10.3390/medsci10030036

Cited by 13 publications

(14 citation statements)

References 35 publications

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“…In 90% patients of perforated appendicitis there's increased bilirubin levels as reported byGavriilidis et al 5 In another study, hyperbilirubinemia was observed in 48% patients of perforated appendicitis. 7 In the research analysiscarried out by Chaudhary et al, hyperbilirubinemia was noticed in the cases of acute suppurative appendicitis, and was much more elevated in cases of perforated as well as gangrenous appendicitis 12,13 .…”

Section: Discussionmentioning

confidence: 98%

Frequency of Hyperbilirubinemia in Perforated Appendicitis - A Current Update on Diagnostics and Management.

Khalid¹,

Sikandar²,

Khan³

et al. 2023

PJMHS

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Background: Perforated appendix can be detected earlier by chemically with the aid of hyperbilirubinemia. It is a simple non-invasive modality that can aid to detecting complicated appendicitis and avoid morbidity. Aim: To assess frequency of hyperbilirubinemia in patients undergoing appendectomy due to perforated appendicitis. Methods: A descriptive cross-sectional study was conducted in which a total of 75 patients undergoing emergency appendectomy due to perforated appendicitis and age 15-70 years were recruited. Patients with CLD, pregnancy, Congenital or acquired biliary disease, alcoholism and hemolytic disease were excluded. Blood sample was obtained and was sent to the hospital histopathology laboratory and it was reported by consultant pathologist for assessment of hyperbilirubinemia. Results: Age range in this study was from 15-70 years with mean age of 30.69±14.37 years. Majority of the patients 56(74.67%) were 15-40 years of age. Out of these 75 patients, 43(57.33%) were male and 32(42.67%) were females. Mean hyperbilirubinemia was 1.67±0.87 mg/dl. Frequency of hyperbilirubinemia in patients undergoing appendectomy due to perforated appendicitis was found in 63 (84.0%) patients. Practical implication: This will aid in prompt diagnosis and early management of perforated appendix, and serum bilirubin can be used as modality for diagnosis in the absence of ultrasound facility. Conclusion: Frequency of hyperbilirubinemia in patients undergoing appendectomy due to perforated appendicitis is very high. Keywords: perforated appendicitis, hyperbilirubinemia, appendectomy, bilirubin level, perforation, sensitivity.

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Section: Discussionmentioning

confidence: 98%

Frequency of Hyperbilirubinemia in Perforated Appendicitis - A Current Update on Diagnostics and Management.

Khalid¹,

Sikandar²,

Khan³

et al. 2023

PJMHS

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“…Hyponatremia also reflected the severity of the underlying process, although it did not induce specific symptoms and might be overlooked by clinicians [ 46 ]. Of note, Shuaib et al revealed that hyperbilirubinemia and hyponatremia yielded a discriminatory value for the diagnosis of complicated appendicitis [ 47 ]. Thus, T-BIL and serum sodium levels can be considered as adjuvant predictors of poor clinical outcomes in neurolisteriosis in all enrolled subjects.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Fatality Risk Factors for Patients with Listeria monocytogenes Infection: A 12-Year Hospital-Based Study in Xi’an, China

Xu,

Peng,

et al. 2024

Infect Dis Ther

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Introduction Listeriosis is a severe food-borne disease caused by Listeria monocytogenes infection. The data of listeriosis in Xi’an population are limited. The aim of this study is to evaluate the clinical features and fatality risk factors for listeriosis in three tertiary-care hospitals in Xi’an, China Methods The characteristics of demographic data, underlying diseases, clinical manifestations, laboratory indicators, cranial imaging examination, antibiotics therapeutic schemes, and clinical outcomes were collected between 2011 and 2023. Logistic regression analysis was performed. Results Seventy-one etiologically confirmed listeriosis patients were enrolled, including 12 neonatal and 59 non-neonatal cases. The majority of neonatal listeriosis presented as preterm (50%) and fetal distress (75%). The main clinical manifestations of non-neonatal listeriosis included fever (88%), headache (32%), disorder of consciousness (25%), vomiting (17%), abdominal pain (12%), and convulsions (8%). The fatality rate in neonatal cases was higher than in non-neonatal listeriosis (42 vs. 17%). Although no deaths were reported in maternal listeriosis, only two of 23 patients had an uneventful obstetrical outcome. Five maternal listeriosis delivered culture-positive neonates, three of whom decreased within 1 week post-gestation due to severe complications. Twenty-eight cases were neurolisteriosis and 43 cases were bacteremia. Neurolisteriosis had a higher fatality rate compared with bacteremia listeriosis (36 vs. 12%). The main neuroradiological images were cerebral edema/hydrocephalus, intracranial infection, and cerebral hernia. Listeria monocytogenes showed extremely low resistance to ampicillin (two isolates) and penicillin (one isolate). The fatality risk factors were the involvement of the central nervous system, hyperbilirubinemia, and hyponatremia for all enrolled subjects. Hyperuricemia contributed to the elevation of fatality risk in non-neonatal listeriosis. Conclusions When the patients suffered with symptoms of fever and central nervous system infection, they should be alert to the possibility of listeriosis. Early administration of ampicillin- or penicillin-based therapy might be beneficial for recovery of listeriosis.

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“…Several studies have focused on markers including laboratory tests, scoring methods for the precise diagnosis of complicated appendicitis. [ 7 , 17 ] The laboratory indicators currently used, such as WBC and CRP are not consistently reliable and their accuracy is questionable. In literature, there have been many studies on various parameters such as serum sodium and bilirubin levels, delta neutrophil index, and NLR that was used for distinguishing complicated appendicitis from uncomplicated cases.…”

Section: Discussionmentioning

confidence: 99%

“…In literature, there have been many studies on various parameters such as serum sodium and bilirubin levels, delta neutrophil index, and NLR that was used for distinguishing complicated appendicitis from uncomplicated cases. [ 8 , 9 , 17 - 24 ]…”

Section: Discussionmentioning

confidence: 99%

A new, simple marker for predicting complicated appendicitis in patients with normal white blood cell count indicator; LUC %

Çetinkaya

Bayazıtlı

Göktaş

et al. 2023

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: The aim of this study was to investigate the ability of a new marker that could be easily obtained to differentiate between complicated and uncomplicated appendicitis in a patients with a white blood cell (WBC) count within the normal range. METHODS: The patients who underwent surgery with histopathologically proven acute appendicitis (AA) between January 2021 and October 2022 were evaluated retrospectively. Patients were classified into two groups as uncomplicated and complicated appendicitis, based on the surgical and histopathological findings. Groups were compared in terms of laboratory parameters at the time of hospital admission. RESULTS: During the study period, 2589 patients underwent an appendectomy, among these 612 patients who had a WBC count within the normal range at the time of admission were analyzed. Uncomplicated appendicitis was detected in 79.6% of the patients and complicated appendicitis in 20.4%. Neutrophil%, neutrophil-to-lymphocyte ratio, C-reactive protein, and total bilirubin levels were significantly higher, whereas lymphocyte%, lymphocyte count, lymphocyte-to-monocyte ratio, sodium levels, and large unstained cells (LUC)% were significantly lower in patients with complicated appendicitis. Multiple logistic regression analysis revealed that lower LUC% (Odds Ratio [OR]: 0.45; 95% Confidence Intervals [CI]: 1.08–2.09; P=0.01) and higher total bilirubin levels (OR: 1.50; 95% CI: 1.08–2.09; P=0.01) were independent risk factors for complicated appendicitis. CONCLUSION: In patients with a diagnosis of AA with a normal WBC value, LUC% obtained from the complete blood count can be used as a new parameter predicting the diagnosis of complicated appendicitis.

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Hyperbilirubinemia and Hyponatremia as Predictors of Complicated Appendicitis

Cited by 13 publications

References 35 publications

Frequency of Hyperbilirubinemia in Perforated Appendicitis - A Current Update on Diagnostics and Management.

Frequency of Hyperbilirubinemia in Perforated Appendicitis - A Current Update on Diagnostics and Management.

Clinical Characteristics and Fatality Risk Factors for Patients with Listeria monocytogenes Infection: A 12-Year Hospital-Based Study in Xi’an, China

A new, simple marker for predicting complicated appendicitis in patients with normal white blood cell count indicator; LUC %

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