Hyperbilirubinemia with Urinary Tract Infection in Infants Younger Than Eight Weeks Old

Rashed, Yasser K.

doi:10.15406/jpnc.2014.01.00036

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…In most of the studies investigating the relationship between UTI and neonatal jaundice, male sex was a significant risk factor compared with female sex in the neonatal period. 8,9,19,20 In accordance with these studies reported, most of the cases (23 of 26) with both UTI and significant hyperbilirubinemia in our study were men. Ghaemi et al 9 have reported that 60% of their male cases with UTI were not circumcised, and Singh-Grewal et al 18 have reported that circumcision significantly reduces the risk of UTI.…”

Section: Discussionsupporting

confidence: 91%

“…In infants with UTI, the prevalence of pyuria has reportedly been 58.3%, 52%, and 33% in 3 different studies, respectively. 4,8,11 In our study, pyuria was present in 15.3% of 26 newborns with UTI.…”

Section: Discussionsupporting

confidence: 50%

“…2 The physiopathologic relationship between neonatal jaundice and UTI has always gained much interest and recently been investigated in various studies. However, this relationship has been preferably studied in newborns with late (⩾8 days) jaundice, [3][4][5][6] prolonged jaundice (⩾15 days), 5,[7][8][9] or conjugated hyperbilirubinemia, 5 and only few studies among newborns with early (⩽7 days) jaundice have been conducted. 2,10,11 Currently, authorized international institutions, such as American Academy of Pediatrics, do not recommend investigation of UTI with urinalysis or urine culture as part of investigations for the etiology of either early or late/prolonged neonatal jaundice.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Early Idiopathic Neonatal Jaundice and Urinary Tract Infections

Özcan

Sarıcı

Yurdugül

et al. 2017

Clin Med Insights Pediatr

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Background and purpose:Etiologic role, incidence, demographic, and response-to-treatment characteristics of urinary tract infection (UTI) among neonates, its relationship with significant neonatal hyperbilirubinemia, and abnormalities of the urinary system were studied in a prospective investigation in early (≤10 days) idiopathic neonatal jaundice in which all other etiologic factors of neonatal hyperbilirubinemia were ruled out.Patients and methods:Urine samples for microscopic and bacteriologic examination were obtained with bladder catheterization from 155 newborns with early neonatal jaundice. Newborns with a negative urine culture and with a positive urine culture were defined as group I and group II, respectively, and the 2 groups were compared with each other.Results:The incidence of UTI in whole of the study group was 16.7%. Serum total and direct bilirubin levels were statistically significantly higher in group II when compared with group I (P = .005 and P = .001, respectively). Decrease in serum total bilirubin level at the 24th hour of phototherapy was statistically significantly higher in group I compared with group II (P = .022).Conclusions:Urinary tract infection should be investigated in the etiologic evaluation of newborns with significant hyperbilirubinemia. The possibility of UTI should be considered in jaundiced newborns who do not respond to phototherapy well or have a prolonged duration of phototherapy treatment.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association Between Early Idiopathic Neonatal Jaundice and Urinary Tract Infections

Özcan

Sarıcı

Yurdugül

et al. 2017

Clin Med Insights Pediatr

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“…Moreover, 55 % of female were affected in our study. Contrary to this, study conducted by Rashed et al showed that male babies are commonly affected 16 . Though at this early age, it is unclear the association between gender and UTI.…”

Section: Discussionmentioning

confidence: 75%

Frequency of Urinary Tract Infection (UTI) in Neonates Admitted with Indirect Hyperbilirubinemia

Ahmed¹,

Jan²,

Zaman³

et al. 2022

PJMHS

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Objective: To determine the frequency of urinary tract infection (UTI) in neonates admitted with indirect hyperbilirubinemia. Study Design: A cross-sectional study. Place and Duration of the Study: Inpatient department of Pediatric Medicine, Bolan Medical College/Hospital Quetta from Jan 2019 to Dec 2020. Methodology: A total of 130 neonates of either gender (delivered at ≥ 32 weeks) admitted with primarily complaints of jaundice (with evidence of indirect hyperbilirubinemia) were included. Sex, age, weight and height of all neonates were noted. Serum bilirubin levels were asses and urine samples were also evaluated for the existence of urinary tract infection (UTI). Results: In a total of 130 neonates, 58 (44.6%) were males and 72 (55.4%) females. The UTI was found to be present in 41 (31.5%) neonates admitted with indirect hyperbilirubinemia. Among these 41 culture proven UTI cases, most common organism was E. coli found in 15 (36.6%) cases while Klebsiella was the 2nd most commonly found microorganism noted in 11 (26.8%) cases. Conclusion: Frequency of UTI was high (31.5%) among asymptomatic jaundiced newborns. Children presenting with jaundice needs to be evaluated for UTI. Keywords: E.Coli, indirect hyperbilirubinemia, Klebsiella , Urinary tract infection (UTI).

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Impact of Diagnostic Criteria on UTI Prevalence in Young Infants With Jaundice: A Meta-analysis

Chang

Schroeder

Lucas

et al. 2022

Hospital Pediatrics

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BACKGROUND AND OBJECTIVE Previously reported prevalence of urinary tract infections (UTIs) in infants with jaundice range from <1% to 25%. However, UTI criteria are variable and, as demonstrated in a meta-analysis on UTI prevalence in bronchiolitis, disease prevalence is greatly impacted by disease definition. The objective of this study was to conduct a systemic review and meta-analysis examining the impact of including positive urinalysis (UA) results as a diagnostic criterion on the estimated UTI prevalence in young infants with jaundice. METHODS The data sources used were Medline (1946–2020) and Ovid Embase (1976–2020) through January 2020 and bibliographies of retrieved articles. We selected studies reporting UTI prevalence in young infants with jaundice. Data were extracted in accordance with meta-analysis of observational studies in epidemiology guidelines. Random-effects models produced a weighted pooled event rate with 95% confidence intervals (CI). RESULTS We screened 526 unique articles by abstract and reviewed 53 full-text articles. We included 32 studies and 16 contained UA data. The overall UTI prevalence in young infants with jaundice from all 32 studies was 6.2% (95% CI, 3.9–8.9). From the 16 studies with UA data, the overall UTI prevalence was 8.7% (95% CI, 5.1–13.2), which decreased to 3.6% (95% CI, 2.0–5.8) with positive UA results included as a diagnostic criterion. CONCLUSIONS The estimated UTI prevalence in young infants with jaundice decreases substantially when UA results are incorporated into the UTI definition. Due to the heterogeneity of study subjects’ ages and definitions of jaundice, positive UA results, and UTI, there is uncertainty about the exact prevalence and about which infants with hyperbilirubinemia warrant urine testing.

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Hyperbilirubinemia with Urinary Tract Infection in Infants Younger Than Eight Weeks Old

Cited by 4 publications

References 8 publications

Association Between Early Idiopathic Neonatal Jaundice and Urinary Tract Infections

Association Between Early Idiopathic Neonatal Jaundice and Urinary Tract Infections

Frequency of Urinary Tract Infection (UTI) in Neonates Admitted with Indirect Hyperbilirubinemia

Impact of Diagnostic Criteria on UTI Prevalence in Young Infants With Jaundice: A Meta-analysis

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