Hyperbranched photo responsive and liquid crystalline azo‐siloxane polymers synthesized by click chemistry

Pandey, Someshwarnath; Mishra, Smita; Kolli, Balakrishna; Kanai, Tapan; Samui, A. B.

doi:10.1002/pola.26042

Cited by 23 publications

(14 citation statements)

References 82 publications

(105 reference statements)

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“…The resultant SHPs showed a liquid crystalline characteristic of nematic phase and a fast photo-response trans-cis isomerization with a rate constant in the range of 0.7-1.4 Â 10 À2 and 7.0-2.5 Â 10 À5 s À1 . 213 An A 2 macromonomer + B 3 macromonomer approach was used to synthesize sequential multiblock SHPs (Scheme 8). The A 2 macromonomer (MM6) was synthesized by the esterification of PEG diols and carboxylic azide.…”

Section: Synthetic Methodologiesmentioning

confidence: 99%

Hyperbranched polymers: advances from synthesis to applications

et al. 2015

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Hyperbranched polymers (HPs) are highly branched three-dimensional (3D) macromolecules. Their globular and dendritic architectures endow them with unique structures and properties such as abundant functional groups, intramolecular cavities, low viscosity, and high solubility. HPs can be facilely synthesized via a one-pot polymerization of traditional small molecular monomers or emerging macromonomers. The great development in synthetic strategies, from click polymerization (i.e., copper-catalyzed azide-alkyne cycloaddition, metal-free azide-alkyne cycloaddition, strain-promoted azide-alkyne cycloaddition, thiol-ene/yne addition, Diels-Alder cycloaddition, Menschutkin reaction, and aza-Michael addition) to recently reported multicomponent reactions, gives rise to diverse HPs with desirable functional/hetero-functional groups and topologies such as segmented or sequential ones. Benefiting from tailorable structures and correspondingly special properties, the achieved HPs have been widely applied in various fields such as light-emitting materials, nanoscience and technology, supramolecular chemistry, biomaterials, hybrid materials and composites, coatings, adhesives, and modifiers. In this review, we mainly focus on the progress in the structural control, synthesis, functionalization, and potential applications of both conventional and segmented HPs reported over the last decade.

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Section: Synthetic Methodologiesmentioning

confidence: 99%

Hyperbranched polymers: advances from synthesis to applications

et al. 2015

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“…A large variety of A and B functional groups have been used, which includes those commonly used for step-growth polymerizations, such as hydroxyl groups with epoxides to prepare hyperbranched aliphatic polyethers, [45] and anhydrides with amines to prepare hyperbranched polyimides, [46,47] but also click chemistry such as azide with alkyne groups involved in copper-assisted alkyneazide cycloaddition (CuAAC) reactions. [48,49] The control of the degree of branching is achieved by controlling the feed ratio and introducing a linear component. However, the A2 + B3 system generally suffers from a tendency to gelation and intramolecular cyclization.…”

Section: Step-growth Copolymerization Of A2 and B3 Monomersmentioning

confidence: 99%

Synthesis and functionalization of hyperbranched polymers for targeted drug delivery

Kavand

Anton

Vandamme

et al. 2020

Journal of Controlled Release

108

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Hyperbranched polymers (HBPs) have found use in a wide range of applications, such as optical, electronic and magnetic materials, coatings, additives, supramolecular chemistry, and biomedicine. HBPs have gained attention for the development of drug delivery systems due to the presence of internal cavities in their three-dimensional globular structure that can be used to encapsulate drugs and their facile synthesis as compared to dendrimers. The composition, topology, and functionality of HBPs have been tuned to design drug carriers with better efficacies. Recent advances have been reported to introduce functional groups to enhance targeting tumor cells. HBPs have been modified to promote passive and active targeting. This review article will describe the different routes to synthesize hyperbranched polymer, their use as drug carriers for targeted drug delivery, and their functionalization with ligands for active targeting through various synthesis strategies to give the reader an extended overview of the progresses accomplished in this field. The modification of HBPs with ligands such as peptides, oligonucleotides, and folic acid have been demonstrated to enhance the accumulation of the drug selectively at the tumor sites. The potential uses and developments of HBPs as nanoobjects for theranostics for example are discussed as perspectives.

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“…“Click chemistry” is a concept introduced by Sharpless [ 54 ] in 2001 and since then has become one of the most powerful paradigms in polymer chemistry and materials science [ 55 , 56 , 57 ]. Due to its simplicity and efficiency, click chemistry has been extensively employed for accessing linear polymers [ 58 , 59 , 60 , 61 , 62 , 63 ], branched polymers [ 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ], dendrimers [ 74 , 75 , 76 , 77 , 78 , 79 ], and polymer networks [ 80 , 81 , 82 , 83 , 84 , 85 ]. The combination of click chemistry and nucleobase-containing polymers is promising.…”

Section: Synthetic Nucleobase-containing Polymersmentioning

confidence: 99%

Nucleobase-Containing Polymers: Structure, Synthesis, and Applications

Yang

2017

Polymers

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Nucleobase interactions play a fundamental role in biological functions, including transcription and translation. Natural nucleic acids like DNA are also widely implemented in material realm such as DNA guided self-assembly of nanomaterials. Inspired by that, polymer chemists have contributed phenomenal endeavors to mimic both the structures and functions of natural nucleic acids in synthetic polymers. Similar sequence-dependent responses were observed and employed in the self-assembly of these nucleobase-containing polymers. Here, the structures, synthetic approaches, and applications of nucleobase-containing polymers are highlighted and a brief look is taken at the future development of these polymers.

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Hyperbranched photo responsive and liquid crystalline azo‐siloxane polymers synthesized by click chemistry

Cited by 23 publications

References 82 publications

Hyperbranched polymers: advances from synthesis to applications

Hyperbranched polymers: advances from synthesis to applications

Synthesis and functionalization of hyperbranched polymers for targeted drug delivery

Nucleobase-Containing Polymers: Structure, Synthesis, and Applications

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