Hyperbranched poly(glycerol esteramide): A biocompatible drug carrier from glycerol feedstock and dicarboxylic acid

Abstract

Polymer carrier with biodegradable, biocompatible as well as solubility enhancing properties are highly looked upon in the pharmaceutical industry to improve the drug delivery systems. A series of hyperbranched poly(glycerol esteramide) (HPGEA) with M w of 5000-12,000 Da, degree of branching of 57%-62%, and hydroxyl values of 200-280 mg KOH/g sample were synthesized through polycondensation of N,N-bis(2-hydroxyethyl)stearamide (diethanolamide) and poly(glycerol ester) (PGE). The HPGEAs were characterized by ATR-FTIR, GPC, 1 H and 13 C-NMR, and DSC. The enthalpy of fusion of HPGEAs (43-84 J g −1) were lower than the commercial polymers (193-391 J g −1), indicating its potential as drug carrier for solid dispersion (SD). HPGEA-based SDs showed substantial enhancement in solubility and release rate than pure drug, commercial polymer-based SDs, as well as commercial formulation. The safety of HPGEAs and HPGEA-based SDs were proven through MTT assay with IC 50 of 2400-9800 and 1200-3500 μg ml −1 , respectively.

Biobased Hyperbranched Poly(ester)s of Precise Structure for the Release of Therapeutics

“…Polymeric materials that are biocompatible and biodegradable are being widely utilized as platforms for the formulation of sustained-release compositions containing a variety of active agents. 22 Hyperbranched polymers often display good solubility and offer a wealth of reactive terminal groups for the attachment of therapeutic agents. Hyperbranched poly(ester)s derived from naturallyoccurring, nontoxic monomers may be particularly useful for the construction of sustained-release formulations.…”

Recent Advances in Nanoparticle Development for Drug Delivery: A Comprehensive Review of Polycaprolactone-Based Multi-Arm Architectures

“…The use of a copolymer with multiarms provides a high number of functional groups incorporated in the structure, which diversifies the application area of such copolymers, including but not limited to drug carriers [150,151], due to the unique physicochemical properties that enhance the efficacity of drugs, as well as thermoplastic elastomers [152], polyelectrolytes [153], hydrogels [154], and adsorption dye removal [155].…”