Hypercalcæmia and Cancer

Hypercalcemia of breast cancer.management with corticosteroids

“…Mammary carcinoma contributes the highest incidence of spontaneous hypercalcemia (1 0 to 12%) among all malignant solid 25 T h e frequency of osseous metastatic involvement in breast cancer may be an important causative factor. Abramsl found the incidence of osseous metastases to be 78% among 1,000 autopsies of patients with breast cancer.…”

Hypercalcemia Associated with Vulvar Carcinoma

“…Nonendocrine tum ors are known to dem onstrate a wide range of hormone activity [1,3]. A num ber of cases of m alignant neoplasm have been reported, accompanied by hypercalcemia, with no evidence of bony métastasés or parathyroid gland alterations [6,7,10,12]. As early as 1941 Albright suggested th at some m alignant tum ors might secrete a substance with parathyroid hormone-like activity.…”

“…As early as 1941 Albright suggested th at some m alignant tum ors might secrete a substance with parathyroid hormone-like activity. Others have as cribed the hypercalcemia accompanying m alignant tum ors to a para thyroid stim ulating hormone, [9] or a vitam in D-like substance secreted by the tum or [6,12].…”

Hypercalcaemia associated with adenocarcinoma of kidney without demonstrable bone lesions.

“…1963; Watson, 1963). Hypercalcaemia due to malignant disease, but unexplained by bone involvement, was first noted by Albright and Reifenstein (1948).…”