Hypercalcaemia in rheumatoid arthritis: investigation of its causes and implications.

Kennedy, A C; Allam, Rabab; Rooney, P. J.; Watson, Melanie; Fairney, Angela; Buchanan, K. D.; Hillyard, C. J.

doi:10.1136/ard.38.5.401

Cited by 31 publications

(13 citation statements)

References 45 publications

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“…Other factors implicated in the bone loss of RA include age (30), menopausal status (31), vitamin D deficiency (32), disability (33) and corticosteroid therapy (34). There is experimental evidence that this factor has some characteristics of parathormone (PTH) and osteoclast activating factor (OAF) (35). Lymphokines and other inflammatory mediators such as interleukins and tumour necrosis factor (TNF) also stimulate bone resorption in inflammatory disease (36,37).…”

Section: Discussionmentioning

confidence: 99%

Metacarpal bone mass in systemic lupus erythematosus

1992

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We report the prevalence of metacarpal cortical thinning in systemic lupus erythematosus (SLE). Fifty-eight ambulant female patients attending a lupus clinic (mean age 32.4 years), were found to have significant thinning of metacarpal cortices (p < 0.05) when compared with 63 normal females (mean age 34.1 years). However, metacarpal bone mass was within the normal range. Measurements were made at 6 metacarpals of the 2 hands using a computer-aided technique (digitized radiogrammetry). Femoral cortical width and Singh index at the left femur, as well as the vertebral index at L3 were also recorded. The trabecular indices were in the range of normality, but the SLE group had more patients in the immediately pre-osteopenic range. Metacarpal bone loss was not related to disease duration or corticosteroid therapy. The prevalence of osteopenia in SLE is probably underestimated and the pathogenesis is likely to be multifactorial.

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Section: Discussionmentioning

confidence: 99%

Metacarpal bone mass in systemic lupus erythematosus

1992

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“…Abnormalities of mineral metabolism suggestive of parathyroid hormone (PTH) excess have been observed in RA,36 but the levels of immunoreactive PTH have been found to be normal in two studies.33 37 Catabolism of PTH involves cleavage of the intact 84 amino acid molecule in the neighbourhood of residue 34 to generate an amino terminal fragment with biological activity and a larger biologically inert fragment containing the mid-region and carboxyl region.38 Assays directed against the mid-region may reflect parathyroid secretory activity more specifically than assays against the carboxyl terminal.39 4( We were unable to show any disturbance in parathyroid gland activity in RA by a mid-molecule PTH assay.…”

Section: Discussionmentioning

confidence: 99%

Bone turnover in early rheumatoid arthritis. 1. Biochemical and kinetic indexes.

Sambrook¹,

Ansell²,

Foster³

et al. 1985

Annals of the Rheumatic Diseases

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and the 2National Institute for Biological Standards and Control, London SUMMARY Biochemical, hormonal, and kinetic indexes of bone turnover were measured in 17 ambulant female patients with rheumatoid arthritis (RA) of recent onset (mean disease duration 14-2 months) and 19 controls. Mean serum osteocalcin concentration and 85Sr accretion rates were reduced and mean urinary hydroxyproline-creatinine ratios were increased in RA, but these differences were not significant compared with control values. Mean total body potassium (TBK), an index of skeletal muscle mass, was significantly reduced in RA, and the ratio of observed to predicted TBK correlated with indexes of bone formation. No abnormality of skeletal metabolism could be shown in early RA, but reduced rates of bone formation associated with diminished muscle mass may influence the development of osteopenia later in the disease.

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“…24-hour urinary calcium (DU-Ca) and creatinine (DU-Crea) excretion were determined with no dietary restrictions. (OH),D) (N = 138) were measured by specific protein binding methods after chromatographic purification (9). The vitamin D values were compared with seasonally adjusted reference values of Kuo-pi0 University Hospital (10).…”

Section: Biochemical Determinationsmentioning

confidence: 99%

Low Serum Vitamin D Metabolites in Women with Rheumatoid Arthritis

Kröger

Penttilä²,

Alhava

1993

Scandinavian Journal of Rheumatology

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The etiology of osteoporosis associated with rheumatoid arthritis (RA) is unknown. We studied the calcium and vitamin D metabolism in 143 women with RA (mean age 50.7 years). Albumin corrected serum calcium was normal. Serum alkaline phosphatase was increased in 29 percent of cases. Serum vitamin D levels were frequently very low. In 16 percent of the RA patients serum 25(OH)D concentration was below 12.5 nmol/L, which is arbitrarily considered as the limit of vitamin D deficiency osteomalacia. In the winter season 73 percent of the patients had serum 1,25(OH)2D levels below the seasonally adjusted normal range. The lowest values were found in patients with high disease activity. We suggest that there is a disturbance in vitamin D metabolism in RA. This might play a role in osteoporosis associated with RA.

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Hypercalcaemia in rheumatoid arthritis: investigation of its causes and implications.

Cited by 31 publications

References 45 publications

Metacarpal bone mass in systemic lupus erythematosus

Metacarpal bone mass in systemic lupus erythematosus

Bone turnover in early rheumatoid arthritis. 1. Biochemical and kinetic indexes.

Low Serum Vitamin D Metabolites in Women with Rheumatoid Arthritis

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