Hypercalcemia as a Biomarker of Poor Prognosis in Frail Elderly Patients with COVID-19

Pamart, Dorian; Otekpo, Marie; Asfar, Marine; Duval, G.; Gautier, Jennifer; Annweiler, Cédric

doi:10.1007/s12603-021-1690-7

Cited by 8 publications

(11 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[2,3] In the past 2 years, many studies have been conducted to identify the predictive factors of severe COVID-19, which showed that older age, high Sequential Organ Failure Assessment score, high procalcitonin levels, high lactate dehydrogenase (LDH) levels, and high D-dimer levels were associated with progression to severe disease and poor clinical outcomes. [4][5][6] Moreover, hypercalcemia in fragile elderly patients with COVID-19 is associated with shorter survival times, [7] and decreased vitamin K levels have also been reported as a poor prognostic factor in severe COVID-19. [8] During the COVID-19 pandemic, it is important to predict severe COVID-19 as it allows for efficient resource allocation.…”

Section: Introductionmentioning

confidence: 99%

Prognostic factors of 30-day mortality in patients with COVID-19 pneumonia under standard remdesivir and dexamethasone treatment

et al. 2022

View full text Add to dashboard Cite

Although some studies have reported prognostic factors for coronavirus disease 2019 (COVID-19), they were conducted before standard treatment with remdesivir and dexamethasone was implemented. This retrospective, observational study was conducted to evaluate various prognostic factors in patients with COVID-19 pneumonia receiving standard treatment with remdesivir and dexamethasone. Of 99 patients with COVID-19 pneumonia, 68 (68.7%) died within 30 days of hospitalization. The mean age was 71.3 years. Remdesivir and dexamethasone were administered to 80 (80.8%) and 84 (84.8%) patients, respectively. Early antibiotic treatment was administered to 70 patients (70.7%) within 5 days of hospitalization. Dexamethasone (79.4% vs 96.8%, P = .033) was more frequently administered in the survived group, whereas early antibiotics (60.3% vs 93.5%, P = .001) were less frequently administered. In the multivariate analysis, a high National Early Warning Score (NEWS; odds ratio [OR] 1.272), high Charlson Comorbidity Index (CCI; OR 1.441), and dyspnea (OR 4.033) were independent risk factors for 30-day mortality. There was no significant difference in age, sex, and vaccination doses between the survived and fatal groups. Lymphopenia, monocytopenia and high levels of C-reactive protein (CRP)/lactate dehydrogenase (LDH) reflected poor prognosis. NEWS, CCI, and dyspnea were predictors of 30-day mortality in patients with COVID-19 pneumonia. Early antibiotic use did not lower the 30-day mortality risk. Abbreviations: CCI = Charlson Comorbidity Index, CI = confidence interval, COVID-19 = coronavirus disease 2019, CRP = C-reactive protein, LDH = lactate dehydrogenase, NEWS = National Early Warning Score, OR = odds ratio, pro-BNP = pro-B-type natriuretic peptide, RT-PCR = reverse transcription-polymerase chain reaction, SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2.

show abstract

Section: Introductionmentioning

confidence: 99%

Prognostic factors of 30-day mortality in patients with COVID-19 pneumonia under standard remdesivir and dexamethasone treatment

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Calcium is essential for viral structure formation, entry, gene expression, viral maturation, and release ( 37 ). COVID-19 patients have increased calcium consumption and disturbed calcium concentrations ( 38 , 39 ). We recently found that calcium disturbances may be an important pathological mechanism of inflammation causing new-onset AF ( 40 ).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive bioinformatics analysis reveals common potential mechanisms, progression markers, and immune cells of coronary virus disease 2019 and atrial fibrillation

Yang

Zhao

2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

ObjectivesAtrial fibrillation (AF) is the most common arrhythmia in coronary virus disease 2019 (COVID-19) patients, especially in severe patients. A history of AF can exacerbate COVID-19 symptoms. COVID-19 Patients with new-onset AF have prolonged hospital stays and increased death risk. However, the mechanisms and targets of the interaction between COVID-19 and AF have not been elucidated.Materials and methodsWe used a series of bioinformatics analyses to understand biological pathways, protein-protein interaction (PPI) networks, gene regulatory networks (GRNs), and protein-chemical interactions between COVID-19 and AF and constructed an AF-related gene signature to assess COVID-19 severity and prognosis.ResultsWe found folate and one-carbon metabolism, calcium regulation, and TFG-β signaling pathway as potential mechanisms linking COVID-19 and AF, which may be involved in alterations in neutrophil metabolism, inflammation, and endothelial cell function. We identified hug genes and found that NF-κb, hsa-miR-1-3p, hsa-miR-124-3p, valproic acid, and quercetin may be key regulatory molecules. We constructed a 3-gene signature consisting of ARG1, GIMAP7, and RFX2 models for the assessment of COVID-19 severity and prognosis, and found that they are associated with neutrophils, T cells, and hematopoietic stem cells, respectively.ConclusionOur study reveals a dysregulation of metabolism, inflammation, and immunity between COVID-19 and AF, and identified several therapeutic targets and progression markers. We hope that the results will reveal important insights into the complex interactions between COVID-19 and AF that will drive novel drug development and help in severity assessment.

show abstract

“… 33 Hypercalcemia in SARS‐CoV‐2 infection is developed due to dysregulation of calcium channels by SARS‐CoV‐2 and associated inflammatory cytokines. 33 As well, proteasome activation is associated with the development of cytokine storm in Covid‐19. 34 Therefore, proteasome inhibitors could be effective against cytokine storm in Covid‐19.…”

Section: The Link Between Covid‐19 and MMmentioning

confidence: 99%

“…In Covid‐19, hypercalcemia is a biomarker linked with poor prognosis and clinical outcomes 33 . Hypercalcemia in SARS‐CoV‐2 infection is developed due to dysregulation of calcium channels by SARS‐CoV‐2 and associated inflammatory cytokines 33 . As well, proteasome activation is associated with the development of cytokine storm in Covid‐19 34 .…”

Section: The Link Between Covid‐19 and MMmentioning

confidence: 99%

The potential link between Covid‐19 and multiple myeloma: A new saga

Al-Kuraishy

Al-Gareeb

Mohammed

et al. 2022

Immunity Inflam & Disease

View full text Add to dashboard Cite

Background Covid‐19 is considered a primary respiratory disease‐causing viral pneumonia and, in severe cases, leads to acute lung injury and acute respiratory distress syndrome (ARDS). In addition, though, extra‐pulmonary manifestations of Covid‐19 have been shown. Furthermore, severe acute respiratory distress syndrome coronavirus type 2 (SARS‐CoV‐2) infection may coexist with several malignancies, including multiple myeloma (MM). Methods This critical literature review aimed to find the potential association between SARS‐CoV‐2 infection and MM in Covid‐19 patients with underlying MM. Narrative literature and databases search revealed that ARDS is developed in both MM and Covid‐19 due to hypercalcemia and proteasome dysfunction. Results Notably, the expression of angiogenic factors and glutamine deficiency could link Covid‐19 severity and MM in the pathogenesis of cardiovascular complications. MM and Covid‐19 share thrombosis as a typical complication; unlike thrombosis in Covid‐19, which reflects disease severity, thrombosis does not reflect disease severity in MM. In both conditions, thromboprophylaxis is essential to prevent pulmonary thrombosis and other thromboembolic disorders. Moreover, Covid‐19 may exacerbate the development of acute kidney injury and neurological complications in MM patients. Conclusion These findings highlighted that MM patients might be a risk group for Covid‐19 severity due to underlying immunosuppression and most of those patients need specific management in the Covid‐19 era.

show abstract

Hypercalcemia as a Biomarker of Poor Prognosis in Frail Elderly Patients with COVID-19

Cited by 8 publications

References 16 publications

Prognostic factors of 30-day mortality in patients with COVID-19 pneumonia under standard remdesivir and dexamethasone treatment

Prognostic factors of 30-day mortality in patients with COVID-19 pneumonia under standard remdesivir and dexamethasone treatment

Comprehensive bioinformatics analysis reveals common potential mechanisms, progression markers, and immune cells of coronary virus disease 2019 and atrial fibrillation

The potential link between Covid‐19 and multiple myeloma: A new saga

Contact Info

Product

Resources

About