Hypercalcemia in childhood renal tumors

Jayabose, Somasundaram; Iqbal, Khalid; Newman, Leonard S.; Filippo, J. Anthony San; Davidian, Marianna M.; Noto, Richard A; Sagel, Inge

doi:10.1002/1097-0142(19880215)61:4<788::aid-cncr2820610424>3.0.co;2-h

Cited by 40 publications

(18 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In pediatric tumors of the kidneys, hypercalcemia has been described exclusively in infants with either malignant rhabdoid tumor or CMN and has been attributed to secretion of PTH or prostaglandin E 2 ; however, that report was from the era prior to identification of PTHrP [17]. PTHrPmediated hypercalcemia in benign tumors is rare.…”

Section: Discussionsupporting

confidence: 67%

Parathyroid-hormone-related protein-mediated hypercalcemia in benign congenital mesoblastic nephroma

et al. 2010

View full text Add to dashboard Cite

Parathyroid hormone-related protein (PTHrP) mediated hypercalcemia of malignancy is rare in children, and even more so in the setting of a benign tumor. We report two infants with PTHrP-mediated hypercalcemia secondary to congenital mesoblastic nephroma and their outcome after removal of the benign tumor. Pre-operatively hypercalcemia was corrected with saline hydration, furosemide, calcitonin and/ or pamidronate. Following resection of the tumor serum PTHrP normalized. Immunohistochemical staining of tumor cells was positive for PTHrP. Post-operatively the infants developed elevated serum parathyroid hormone with low- normal serum Ca and P, and undetectable urinary Ca and P, probably due to their movement into bone. Children needed treatment with calcitriol, Ca and P supplementation for 6-12 weeks until PTH normalized and urinary Ca and P were detected, suggesting bone replenishment. We conclude that benign congenital mesoblastic nephroma can secrete PTHrP that can cause severe hypercalcemia; and following excision one should anticipate the development of a transient modified "hungry bone"-like condition requiring Ca, P and calcitriol therapy for several weeks accompanied by careful monitoring of mineral homeostasis.

show abstract

Section: Discussionsupporting

confidence: 67%

Parathyroid-hormone-related protein-mediated hypercalcemia in benign congenital mesoblastic nephroma

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Hypercalcemia, which is an uncommon finding in childhood tumors but has been reported in infants with MRT, 8,17 was observed in 3 patients (all aged <12 months). Consistent with past series, 4,5,8 our patients tended to present with advanced disease-all but 3 patients had stage III or IV disease at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Extracranial malignant rhabdoid tumors in childhood

Madigan

Armenian

Malogolowkin

et al. 2007

Cancer

View full text Add to dashboard Cite

BACKGROUND.Extracranial malignant rhabdoid tumor (MRT) is a rare, aggressive, pediatric malignancy with a historically poor outcome. Recent efforts to intensify treatment for MRT have resulted in isolated reports of long‐term survival.METHODS.The authors conducted a retrospective review of consecutive patients with MRT at Childrens Hospital Los Angeles over the 20 years from 1983 to 2003.RESULTS.Fourteen children were diagnosed with MRT over the 20‐year study period. The median age at presentation was 22.5 months (range, 0.5–108 months). Five patients had renal primary tumors, and 9 patients had extrarenal tumors. Eleven of 14 patients had stage III or IV disease at diagnosis. Five patients (35.7%) were long‐term survivors. The time to disease progression was rapid (mean, 3.6 months). There were no recurrences or deaths beyond 10 months after diagnosis. All survivors received multimodal therapy, including both chemotherapy and surgery with or without radiation. In addition, 2 patients received high‐dose chemotherapy with hematopoietic stem cell rescue (HSCT) after neoadjuvant chemotherapy and local tumor control. Both of those patients were long‐term survivors. There were no survivors after disease recurrence or progression.CONCLUSIONS.Patients with localized disease and complete surgical resection were most likely to survive long‐term. Consolidation with HSCT may benefit selected patients with advanced disease stage. International collaboration and further understanding of the biology of this disease is necessary to improve the survival of children with MRT. Cancer 2007. © 2007 American Cancer Society.

show abstract

“…It has been reported in association with childhood renal tumors in 1.2% of cases, compared with 0.7% among childhood solid tumors in general [9]. When complicating childhood renal tumors, hypercalce- mia is usually associated with MRTK or CMN, and is believed to be a consequence of the secretion of PTH, PTH-related peptide [10], or prostaglandin (PG) E 2 [11]. Although MRTK is reported to metastasize to the skeletal system, osseous involvement is reported in less than 5% of cases [3].…”

Section: Discussionmentioning

confidence: 64%

Congenital mesoblastic nephroma associated with polyhydramnios and hypercalcemia

Daskas¹,

Argyropoulou

Pavlou³

et al. 2002

Pediatr Nephrol

View full text Add to dashboard Cite

Congenital mesoblastic nephroma (CMN) can present with atypical clinical and imaging findings. A premature male neonate was born to an 18-year-old woman after 33 weeks' gestation, which was complicated by polyhydramnios and placenta abruptio. A right abdominal mass was diagnosed antenatally. From the 1st day of life, the newborn had hypercalcemia with initially normal parathormone levels and polyuria for the first hours of life and normal urine output afterwards. Ultrasonographic study and magnetic resonance imaging of the abdomen showed at the upper pole of the right kidney a heterogeneous, solid, poorly defined mass, partially surrounded by a subcapsular fluid collection mimicking malignant rhabdoid tumor of the kidney. Surgical resection revealed a CMN of mixed, classic, and in areas, cellular type. One year after the resection, the patient is asymptomatic and normocalcemic. In conclusion, CMN may present with atypical clinical and imaging findings, necessitating an extensive work-up in order to exclude highly malignant renal tumors of the neonatal period.

show abstract

Hypercalcemia in childhood renal tumors

Cited by 40 publications

References 21 publications

Parathyroid-hormone-related protein-mediated hypercalcemia in benign congenital mesoblastic nephroma

Parathyroid-hormone-related protein-mediated hypercalcemia in benign congenital mesoblastic nephroma

Extracranial malignant rhabdoid tumors in childhood

Congenital mesoblastic nephroma associated with polyhydramnios and hypercalcemia

Contact Info

Product

Resources

About