Hypercalcemia in Patients with Newly Diagnosed Tuberculosis in Abuja, Nigeria

Dosumu, E. A.; Momoh, JA

doi:10.1155/2006/407609

Cited by 14 publications

(13 citation statements)

References 23 publications

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“…[13] In the incidence studies mentioned above, it was found that patients with granulomatous disorders and hypercalcemia were from areas where there was increased calcium and Vitamin D consumption in their daily diet. [56789] Our patient, a daily laborer also was a gentleman who used to work in the sun, which could explain the elevated circulating activated Vitamin D causing severe hypercalcemia. Our patient also had renal failure at presentation which could be one of the presentations of hypercalcemia.…”

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confidence: 98%

“…[34] The incidence of hypercalcemia in tuberculosis varies from 2% to 25% depending on the geographical area where the study was conducted and is depended on multiple other factors such as the intake of calcium, Vitamin D, and exposure to the sun. [56789] In a study carried out in Jabalpur Military Hospital, in 94 patients with active tuberculosis, only 5 had hypercalcemia. [10] Mechanism of hypercalcemia in tuberculosis is considered to be due to the extra-renal production of 1,25(OH) 2 D 3 by alveolar macrophages and T lymphocytes possibly CD8 T lymphocytes.…”

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confidence: 99%

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Severe hypercalcemia in a patient with pulmonary tuberculosis

Rajendra

Mishra

Francis

et al. 2016

J Family Med Prim Care

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confidence: 98%

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confidence: 99%

Severe hypercalcemia in a patient with pulmonary tuberculosis

Rajendra

Mishra

Francis

et al. 2016

J Family Med Prim Care

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“…The prevalence of hypercalcemia in patients with tuberculosis is quite variable between countries, varying from approximately 2.3% in some studies (3) to 14.7-50.6% in other studies (6)(7)(8)(9)(10)(11)(12)(13)(14) ( Table 2). This variation has been largely attributed to disparity in vitamin D and calcium intake, the degree of sunlight exposure as well as the criteria for the diagnosis for hypercalcemia (4).…”

Section: Discussionmentioning

confidence: 99%

Acute hypercalcemia and hypervitaminosis D associated with pulmonary tuberculosis in an elderly patient : A case report and review of the literature.

Wada¹,

Hashimoto

Saijo

2019

J. Med. Invest.

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An 80-year-old man was referred to our hospital for further examination of fever, cough and left pleural effusion. The laboratory findings showed acute inflammation, and the elevation of albumin-corrected serum calcium and 1,25-dihydroxyvitamin D3. A chest CT revealed centrilobular particulate opacity in the bilateral lung fields and left pleural effusion, indicating acute hypercalcemia and hypervitaminosis D associated with pulmonary tuberculosis. By the confirmation of Mycobacterium tuberculosis on polymerase chain reaction and cultures of the sputum and pleural effusion, a diagnosis of pulmonary tuberculosis was made. The patient successfully completed a 9-month course of the anti-tuberculosis treatment, and bilateral infiltrative shadows and left pleural effusion in chest X-ray disappeared. Symptoms progressively improved and serum level of albumin-corrected calcium and 1,25-dihydroxyvitamin D3 eventually normalized. While pulmonary tuberculosis is an infrequent cause of hypercalcemia, it should be considered in patients with hypercalcemia and elevated serum level of 1,25-dihydroxyvitamin D3.

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“…A close relation between abnormal calcium metabolism and radiological extent of disease has been described in pulmonary TB patients [33,34]. Alterations in serum calcium, particularly cases of hypercalcemia, have been observed in adult TB patients [33-35]. Hypercalcemia in pediatric TB patients is an infrequently recognized and poorly understood phenomenon [36].…”

Section: Discussionmentioning

confidence: 99%

A predictive signature gene set for discriminating active from latent tuberculosis in Warao Amerindian children

et al. 2013

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BackgroundTuberculosis (TB) continues to cause a high toll of disease and death among children worldwide. The diagnosis of childhood TB is challenged by the paucibacillary nature of the disease and the difficulties in obtaining specimens. Whereas scientific and clinical research efforts to develop novel diagnostic tools have focused on TB in adults, childhood TB has been relatively neglected. Blood transcriptional profiling has improved our understanding of disease pathogenesis of adult TB and may offer future leads for diagnosis and treatment. No studies applying gene expression profiling of children with TB have been published so far.ResultsWe identified a 116-gene signature set that showed an average prediction error of 11% for TB vs. latent TB infection (LTBI) and for TB vs. LTBI vs. healthy controls (HC) in our dataset. A minimal gene set of only 9 genes showed the same prediction error of 11% for TB vs. LTBI in our dataset. Furthermore, this minimal set showed a significant discriminatory value for TB vs. LTBI for all previously published adult studies using whole blood gene expression, with average prediction errors between 17% and 23%. In order to identify a robust representative gene set that would perform well in populations of different genetic backgrounds, we selected ten genes that were highly discriminative between TB, LTBI and HC in all literature datasets as well as in our dataset. Functional annotation of these genes highlights a possible role for genes involved in calcium signaling and calcium metabolism as biomarkers for active TB. These ten genes were validated by quantitative real-time polymerase chain reaction in an additional cohort of 54 Warao Amerindian children with LTBI, HC and non-TB pneumonia. Decision tree analysis indicated that five of the ten genes were sufficient to classify 78% of the TB cases correctly with no LTBI subjects wrongly classified as TB (100% specificity).ConclusionsOur data justify the further exploration of our signature set as biomarkers for potential childhood TB diagnosis. We show that, as the identification of different biomarkers in ethnically distinct cohorts is apparent, it is important to cross-validate newly identified markers in all available cohorts.

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Hypercalcemia in Patients with Newly Diagnosed Tuberculosis in Abuja, Nigeria

Abstract: Hypercalcemia is not uncommon among Nigerian patients with newly diagnosed TB, but it is rarely symptomatic.

Cited by 14 publications

References 23 publications

Severe hypercalcemia in a patient with pulmonary tuberculosis

Severe hypercalcemia in a patient with pulmonary tuberculosis

Acute hypercalcemia and hypervitaminosis D associated with pulmonary tuberculosis in an elderly patient : A case report and review of the literature.

A predictive signature gene set for discriminating active from latent tuberculosis in Warao Amerindian children

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