Hypercalcemia Related Pancreatitis

Kumar, Anil; Kumar, PG; Pujahari, AK; Somanna, Sampath

doi:10.1016/s0377-1237(10)80025-5

Cited by 13 publications

(11 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hypercalcemia as a cause of pancreatitis is very rarely reported, with an incidence of 0.4% [82]. Increased plasma levels of calcium may lead to AP through a block of enzymatic secretion and accumulation of digestive zymogens within the pancreatic acinar cells [83].…”

Section: Hypercalcemiamentioning

confidence: 99%

Idiopathic acute pancreatitis: a review on etiology and diagnostic work-up

Blanco

Gesuale

Varanese

et al. 2019

Clin J Gastroenterol

View full text Add to dashboard Cite

Acute pancreatitis (AP) is a common disease associated with a substantial medical and financial burden, and with an incidence across Europe ranging from 4.6 to 100 per 100,000 population. Although most cases of AP are caused by gallstones or alcohol abuse, several other causes may be responsible for acute inflammation of the pancreatic gland. Correctly diagnosing AP etiology is a crucial step in the diagnostic and therapeutic work-up of patients to prescribe the most appropriate therapy and to prevent recurrent attacks leading to the development of chronic pancreatitis. Despite the improvement of diagnostic technologies, and the availability of endoscopic ultrasound and sophisticated radiological imaging techniques, the etiology of AP remains unclear in ~ 10-30% of patients and is defined as idiopathic AP (IAP). The present review aims to describe all the conditions underlying an initially diagnosed IAP and the investigations to consider during diagnostic work-up in patients with non-alcoholic non-biliary pancreatitis.

show abstract

Section: Hypercalcemiamentioning

confidence: 99%

Idiopathic acute pancreatitis: a review on etiology and diagnostic work-up

Blanco

Gesuale

Varanese

et al. 2019

Clin J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Acute pancreatitis can occur due to hypercalcemia and not directly due to the CYP24A1 gene mutation. Although hypercalcemia is a rare cause of acute pancreatitis, clinicians should always take steps to rule it out from the differential diagnosis [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Hypercalcemia and CYP24A1 Gene Mutation Diagnosed in the 2nd Trimester of a Twin Pregnancy: A Case Report

et al. 2021

View full text Add to dashboard Cite

Patient: Female, 33-year-old Final Diagnosis: Hypercalcemic crisis • pregnancy Symptoms: Hypercalcemia • hypertension • hypertensive crisis • pregnancy Medication: — Clinical Procedure: — Specialty: Genetics Objective: Rare disease Background: Loss-of-function mutations of the CYP24A1 gene cause a deficiency of the CYP24A1 enzyme, which is involved in the catabolism of 1,25-dihydroxyvitamin D3. Patients who are CYP24A1 enzyme deficient are at increased risk of developing hypercalcemia during pregnancy and should avoid additional vitamin D supplementation. This case report provides additional information for managing and diagnosing patients with a CYP24A1 gene mutation. Case Report: A primipara woman with a twin pregnancy was admitted to our hospital for frequent hypertensive crises. She had no history of hypercalcemia-associated signs and symptoms except nephrocalcinosis, and reported no other abnormalities or discomfort at presentation. Laboratory tests revealed that the parathyroid hormone level was suppressed and the serum calcium level was markedly increased. The 25-hydroxyvitamin D level was at the upper limit of the reference range while the 1,25-dihydroxyvitamin D3 level was elevated, suggesting a vitamin D catabolism disorder. A genetic test was performed and a homozygous likely pathogenic variant (based on the American College of Medical Genetics and Genomics guidelines) c.964G>A (p.Glu322Lys) was detected in the CYP24A1 gene (NM_000782.5). A cesarean section delivery was performed due to a single intrauterine demise at 33 weeks of gestation. The preterm newborn was diagnosed with transitional hypercalcemia and hyperphosphatemia; however, he was not treated, as he was asymptomatic. Conclusions: Patients with a CYP24A1 gene mutation are at increased risk of hypercalcemia and fetal demise; therefore, 25-hydroxyvitamin D and calcium levels should be monitored in routine blood tests during pregnancy. Hypercalcemia in a newborn should be carefully evaluated and treated, as hypercalciuria can lead to nephrocalcinosis.

show abstract

“…Although the precise cause is not understood, the hypothesis may be that chylomicron and free fatty acids, which increase plasma viscosity, may trigger ischemia and organ inflammation [15]. It is hypothesized that hypercalcemia causes pancreatic damage by conversion of trypsinogen to trypsin [16].…”

Section: Discussionmentioning

confidence: 99%