Hypercalciuria in a new rat model of hyperprolactinemia

Adler, Robert A.; Farrell, Mary E.; Deiss, William P.; Krieg, Richard J.; MacLeod, Robert M.

doi:10.1016/0026-0495(91)90112-a

Cited by 9 publications

(1 citation statement)

References 17 publications

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“…During the current experiments, therefore, we could be certain that pup bone development would not be influenced by altered levels of maternal steroid hormones. Also unaltered by this protocol were maternal levels of PTH, elevations of which would increase bone turnover rate (11); calcium, an aggregate marker of intestinal uptake; kidney reabsorption and deposition/resorption in bone, the first two of which are reportedly influenced by PRL (2,24); and AP, a marker of bone formation (33). Thus we had good evidence that changes in fetal bone development were not secondary to changes in maternal bone metabolism or the availability of calcium.…”

Section: Discussionmentioning

confidence: 99%

Effects of prolactin on osteoblast alkaline phosphatase and bone formation in the developing rat

Coss

Yang

Kuo

et al. 2000

American Journal of Physiology-Endocrinology and Metabolism

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The purpose of the current study was to determine whether maternal prolactin (PRL) had any effects on bone formation in the developing rat pup. Because the most prevalent forms of PRL in rats are unmodified and phosphorylated PRL, both recombinant PRL and a molecular mimic of phosphorylated PRL (PP-PRL) were administered to pregnant animals. Blood samples from the dams showed normal estrogen and progesterone and no effect of extra PRL on parathyroid hormone (PTH), calcium, or alkaline phosphatase (AP). In newborn pups, however, there was a 30% decrease in blood AP in both PRL-treated groups, whereas PTH and calcium levels were not different from controls. When primary rat osteoblasts were exposed to both PRLs, AP activity was reduced, with PP-PRL being the more potent form of the hormone. Histological examination of pup bone formation showed reduced calvarial bone and reduced endochondral ossification in pups exposed to PP-PRL. These results are the first to show a direct inhibitory effect of PRL on osteoblast function.

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Section: Discussionmentioning

confidence: 99%