Hypercalciuria is a common and important finding in postmenopausal women with osteoporosis

Giannini, Sandro; Nobile, M.; Carbonare, Luca Dalle; Lodetti, M. G.; Sella, Stefania; Vittadello, Gabriele; Minicuci, Nadia; Crepaldi, Gaetano

doi:10.1530/eje.0.1490209

Cited by 62 publications

(52 citation statements)

References 21 publications

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“…Several studies demonstrated that IH in childhood is associated with low BMD (31,32), suggesting that life-long hypercalciuria may compromise bone health and increase fracture risk. In addition, studies in postmenopausal women with primary osteoporosis have reported a 10%-19% prevalence of hypercalciuria (33,34).…”

Section: Discussionmentioning

confidence: 99%

Risk of Fracture in Urolithiasis

Denburg

Leonard

Haynes

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Studies have shown decreased bone mineral density in individuals with urolithiasis, but their burden of fracture remains unclear. This study sought to determine whether urolithiasis is associated with increased fracture risk across the lifespan and to delineate sex effects.Design, setting, participants, & measurements A population-based retrospective cohort study using The Health Improvement Network was performed. The median calendar year for the start of the observation period was 2004 (1994-2012). This study identified 51,785 participants with $1 of 87 diagnostic codes for urolithiasis and 517,267 randomly selected age-, sex-, and practice-matched participants. Cox regression was used to estimate the hazard ratio (HR) for first fracture. Fractures identified using diagnostic codes were classified by anatomic site.Results Median age was 53 years, and 67% of participants were men, confirming their greater urolithiasis burden. Median time from urolithiasis diagnosis to fracture was 10 years. The HR for fracture associated with urolithiasis differed by sex and age (P for interactions, P#0.003). In men, the adjusted HR was greatest in adolescence (1.55; 95% confidence interval [95% CI], 1.07 to 2.25) with an overall HR of 1.10 (95% CI, 1.05 to 1.16). Urolithiasis was associated with higher fracture risk in women aged 30-79 years (HR, 1.17-1.52), and was highest in women aged 30-39 years (HR, 1.52; 95% CI, 1.23 to 1.87). Peak background fracture rates were highest in boys aged 10-19 years and in women aged 70-79 years. The incidence per 10,000 person-years in participants with versus without urolithiasis was 392 versus 258 in male participants aged 10-19 years, and 263 versus 218 in women aged 70-79 years. Distribution of fracture site within sex did not differ between participants with versus without urolithiasis.Conclusions Urolithiasis was associated with higher incident fracture risk. The significantly higher risk at times of peak background fracture incidence in adolescent boys and elderly women has profound public health implications.

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Section: Discussionmentioning

confidence: 99%

Risk of Fracture in Urolithiasis

Denburg

Leonard

Haynes

et al. 2014

Clinical Journal of the American Society of Nephrology

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“…[16] This can account for the differences between this study and that of Shiarishi et al [17] This loss of calcium is, nevertheless, important, as hypercalciuria is one of the most common features of postmenopausal bone loss with osteoporosis in 50% of patients. [18,19] As the name refers, bone mineral density is a measure of the mineral content of a bone or specific region of a bone and, therefore, it indicates a measure of strength of a bone. In the present study, the diameters of the tibial head and shaft were significantly reduced in the unsupplemented Ovx group.…”

Section: Discussionmentioning

confidence: 99%

The effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model

Ozsahin

Çam

Dere

et al. 2017

Turk J Phys Med Rehab

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Objectives: This study aims to investigate the effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model. Materials and methods:Between May 2006 and July 2006, 60 female Wistar Albino rats aged three months were randomly allocated to three groups: sham operated receiving no treatment (Shm); ovariectomized-alendronate receiving 1 mg/kg/day alendronate sodium (Ovx-A), and ovariectomized-vehicle receiving 1 mL/kg/day physiological saline (Ovx-PS). Both Ovx groups received treatment through gastric gavage for 56 days.Results: Densitometric measurements showed that bone mineral density decreased in the Ovx-PS and increased in Ovx-A groups (p<0.05). Biomechanical measurements showed a decrease in the breaking force in the Ovx-PS group and an increase in the Ovx-A group (p<0.05). Histomorphometric measurements showed that the Shm group had normal trabecular structure, while the Ovx-PS group had a less wellformed trabecular structure with a loss in the trabecular number and thickness and a corresponding increase in the trabecular spacing (p<0.05). In the Ovx-A group, there was an improvement in the trabecular structure with an increase in the trabecular number and thickness and a loss in the trabecular space (p<0.05). Conclusion:Our study results suggest that alendronate sodium is a valuable treatment agent for osteoporosis in postmenopausal women.

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“…Neste estudo, a HC esteve presente em 15% das pacientes analisadas, valor este semelhante a alguns estudos (4,5), porém superior ao trabalho de Tannenbaum e cols., que encontraram uma incidência de 10% (7). Alguns autores demonstraram correlação negativa entre a HC e a densidade óssea, ou seja, quanto maior a HC menor a DMO (4).…”

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“…Além disso, Giannini e cols. mostraram que a hipercalciúria foi um fator significativo na redução da massa óssea (5).…”

Section: Hipercalciúria Na Osteoporoseunclassified

Prevalência de hipercalciúria em mulheres na pós-menopausa com osteoporose

Carvalho

Kulak

Borba

2012

Arq Bras Endocrinol Metab

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RESUMOObjetivo: Analisar a prevalência de hipercalciúria em mulheres na pós-menopausa com osteoporose e avaliar associação de hipercalciúria com parâmetros clínicos e do metabolismo osteomineral. Sujeitos e métodos: Foram estudadas 127 mulheres. A calciúria foi determinada em urina de 24 horas. A DMO foi medida em coluna lombar e fêmur por dupla emissão de energia (DXA). Resultados: A média de idade foi de 64 ± 8 anos. De acordo com a excreção urinária de cálcio, as pacientes foram divididas em normo e hipercalciúricas (HC). Das 127 pacientes, 19 (15%) foram classificadas como HC. Houve diferença entre os grupos apenas na idade de início da menopausa (46 ± 6 vs. 50 ± 3 anos HC, p < 0,0005). Não houve associação entre calciúria e idade, IMC, DMO, cálcio, fósforo, PTH e fosfatase alcalina. Conclusão: A HC é frequente em mulheres na pós-menopausa com osteoporose, e a medida da calciúria deve ser incluída na investigação dessas pacientes. Arq Bras Endocrinol Metab. 2012;56(1):1-5 Descritores Hipercalciúria; osteoporose; densidade óssea; hormônio paratireóideo ABSTRACT Objective: To determine the prevalence of hypercalciuria (HC) in postmenopausal women with osteoporosis and its relationship with clinical data and bone mineral metabolism. Subjects and methods: Calciuria was measured in 24-hour urine samples of 127 women. BMD was measured in the lumbar spine and femur by dual-energy X-ray absorptiometry (DXA). Results: Mean age (±SD) was 64 (±8) years. According to urinary calcium excretion, patients were divided into normo-and hypercalciuric (HC). Of the 127 patients, 19 (15%) were classified as HC. The only difference between the groups was the age of onset of menopause (46 ± 6 vs. 50 ± 3 years HC, p < 0.0005). No association was found between calciuria and age, BMI, BMD, calcium, phosphorus, PTH, and alkaline phosphatase. Conclusion: HC is frequent in postmenopausal women with osteoporosis, and calciuria measurement should be included in the investigation of these patients. Arq Bras Endocrinol Metab. 2012;56(1):1-5 Keywords Hypercalciuria; osteoporosis; bone density; parathyroid hormone INTRODUÇÃO A osteoporose é definida como um distúrbio esquelé-tico caracterizado por diminuição da massa e deterioração da microarquitetura óssea, que leva à piora da qualidade do osso e, por consequência, ocasiona aumento do risco de fraturas por fragilidade (1). A medida da densidade mineral óssea, por meio da absorciometria de raios X de dupla energia (DXA), é utilizada como meio diagnóstico e representa aproximadamente 70% da massa óssea total. A Organização Mundial da Saúde definiu osteoporose como densidade mineral óssea (DMO) menor que 2,5 desvios-padrão abaixo da média de uma população de adultos jovens (2).

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Hypercalciuria is a common and important finding in postmenopausal women with osteoporosis

Cited by 62 publications

References 21 publications

Risk of Fracture in Urolithiasis

Risk of Fracture in Urolithiasis

The effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model

Prevalência de hipercalciúria em mulheres na pós-menopausa com osteoporose

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