Hypercaloric Diet and Vitamin E Intake

Radulescu, Catalina; Miricescu, Daniela; Totan, Alexandra; Didilescu, Andreea Cristiana; Stănescu, Iulia-Ioana; Rădulescu, Radu; Stănescu, Ana Maria Alexandra; Ştefani, Constantin; Greabu, Maria

doi:10.37358/mp.19.4.5287

Mat.Plast.

2019

DOI: 10.37358/mp.19.4.5287

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Hypercaloric Diet and Vitamin E Intake

Catalina Radulescu¹,

Daniela Miricescu²,

Alexandra Totan³

et al.

Abstract: PLGA (poly-lactic-co-glycolic acid) nanoparticles represent an important synthetic biocomponent that has the potential to be a promising carrier of drugs, proteins, nucleic acids, due to its biodegradability and minimal side effects. The aim of our study was to observe the antioxidant effect of vitamin E loaded in PLGA nanoparticles administered over a period of 3 weeks in Wistar rats treated with a hypercaloric diet. Glutathione (GSH) and malondiadehyde (MDA) biomarkers determined from liver lysate were an… Show more

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Cited by 3 publications

References 44 publications

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Gut microbiota and obesity

Radu¹,

Sîrbu²,

Axelerad³

et al. 2022

RJMM

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Worldwide, adults and childhood obesity are increasing alarmingly, being a major health problem. Obesity is correlated with an increased incidence of various systemic diseases including cancer, heart diseases, and diabetes mellitus type 2. Risk factors for obesity are dysbiosis, genetic, socioeconomic, behavioural and environmental. The gut microbiota has beneficial effects on human health, like host immune system stimulation, being influenced by pH, or nutrient intake. Studies performed on humans and animal models reported differences regarding microbiota at lean and obese individuals. The consumption of probiotics and prebiotics may balance the microbiota with positive effects in obesity. The main aim of this review is to reveal the interaction between dysbiosis and obesity

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Gut microbiota and obesity

Radu¹,

Sîrbu²,

Axelerad³

et al. 2022

RJMM

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The Impact of the Hypercaloric Diet versus the Mediterranean Diet on Insulin Sensitivity

Ranetti¹,

Vasile²,

Sirbu³

et al. 2023

RJMM

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"Obesity affects the population worldwide. A hypercaloric diet associated with a sedentary life, stress, and genetic background, triggers various metabolic disorders, such as metabolic syndrome, diabetes mellitus, cancer, cardiovascular diseases, non-alcoholic fatty liver disease, and cognitive impairment. A healthy diet correlated with physical activity, not smoking, and moderate alcohol consumption reduces the risk of developing metabolic diseases. The Mediterranean diet contains antioxidants, fiber, polyunsaturated fats, and compounds with anti-inflammatory, anti-oxidant, anti-cancer, and anti-obesity properties. In a wide variety of species including humans, the reduction of calories between 20-40% significantly improves health, increaseslongevity, and delaysthe development of various pathologies. The main aim of this review is to present the comparative effects of the Mediterranean diet versus the hypercaloric diet on insulin sensitivity. "

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Assessment of Low-Doses Doxorubicin Effects in Mice Using Chromosomal Aberration Assay

Costache,

Nica,

Nica

et al. 2023

RJMM

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"The cytogenetic aberrations induced by doxorubicin (DOX) may be influenced by diet. Investigation regarding effects of low doses of DOX on chromosomal aberrations frequency in mice bone marrow. The study explored a possible relationship between diet, follow-up period, and cytostatic doses. Four mice groups received normal or high-fat (pork) diet. At the beginning of the 8th day mice from each group received a single intraperitoneal injection with DOX (dose range: 1.7-7.7 mg/kg b.w.) or isotonic saline solution (0.02 mL/g control mice). In the 10th (groups I, II) and 14th (groups III, IV) days from the beginning of the experiment, the mice were euthanized and chromosome aberrations were tested in bone marrow cells. The body weight of all mice who received DOX decreases, especially at higher doses. In the first three days post-injection, weight loss percentage was significantly influenced by DOX doses and/or type of diet (p<0.003). The interaction between the type of diet and DOX doses was not statistically significant in the follow-up period (p interactions >0.05). DOX doses were able to increase the frequency of chromosomal aberrations. DOX acts as a potent inductor of cytogenetic aberrations in bone marrow cells, regardless of the type of diet."

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Hypercaloric Diet and Vitamin E Intake

Cited by 3 publications

References 44 publications

Gut microbiota and obesity

Gut microbiota and obesity

The Impact of the Hypercaloric Diet versus the Mediterranean Diet on Insulin Sensitivity

Assessment of Low-Doses Doxorubicin Effects in Mice Using Chromosomal Aberration Assay

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