Hypercholesterolemia as a risk factor for coronary heart disease

Abstract

Familial Hypercholesterolemia (FH) is a genetic disorder, an expression of a defect in the gene that is responsible for the production of LDL-C receptor. The current study was designed to determine the FH patients in the city of Sulaymaniyah for both sexes. The study included 213 samples, the number of males was 99 and the number of females was 114, both sexes ranged from (30-79) years. The results of cholesterol, triglyceride, high density lipoprotein (HDL-C), and lowdensity lipoprotein (LDL-C) in patients with hypercholesterolemia showed highly significant (P ˂ 0.01) for cholesterol and triglyceride in patients with compared healthy people. (HDL-C and LDL-C) showed a significant decrease (P ˂ 0.01) in the concentration of HDL-C in patients with hypercholesterolemia compared to their level of concentration in healthy individuals, in relation to low-density lipoprotein (LDL-C) -C is the other (P ˂ 0.01) in the concentration level in patients with hypercholesterolemia compared to the level of concentration of healthy.As concerns the effect of hypercholesterolemia on coronary heart disease, the results showed a significant increase (P ˂ 0.01) in cholesterol, triglycerides and LDL-C with a significant decrease in HDL-C concentration in people with heart disease compared with healthy people.

Pengaruh Pemberian Ekstrak Etanol Daun Sisik Naga (Pyrrosia Piloselloides L.) terhadap Penurunan Kadar Kolesterol Total Mencit Hiperkolesterolemia

“…Kolesterol merupakan senyawa lemak kompleks yang berada dalam darah dan sel-sel tubuh manusia, berfungsi membentuk membran sel, prekursor pembentukan hormon steroid, hormon seks, vitamin D dan asam empedu [1], [2]. Nilai normal kolesterol total dalam darah adalah <200 mg/dl, jika nilai kolesterol total melebihi normal maka kondisi ini disebut hiperkolesterolemia [3].…”

“…Hiperkolesterolemia merupakan faktor risiko terbesar penyebab penyakit kardiovaskular seperti hipertensi, aterosklerosis, stroke, dan penyakit jantung koroner [3], [4]. Penyakit kardiovaskular perlu diwaspadai karena penyebab kematian nomor satu di dunia [5].…”