Hypercholesterolemia as the first manifestation of metabolic abnormalities in normoglycemic young adult male with family history of type 2 diabetes mellitus

Purnamasari, Dyah; Aulia, Rezky; Abdaly, Muhammad Syah; Hazim, Ahmad

doi:10.1016/j.dsx.2018.12.019

Cited by 4 publications

(9 citation statements)

References 11 publications

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“…The relationship between diabetes and lipid profile has been intensively studied by researches for decades. The number of patients who suffer from diabetes is in a rise according to the WHO data (Purnamasari et al, 2019). From the literature, it has been shown that Type 2 diabetes mellitus causes an increase of the risks to coronary heart disease (CHD) and hyperlipidemias (Nakhjavani et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Association of Lipid Profile with Body Mass Index in Public Employees in Halabja City, Kurdistan Region of Iraq

et al. 2020

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Obesity and overweight are extensive phenomena that reached epidemics extent worldwide, including the Kurdistan region of Iraq. The aim of this study is to evaluate the values of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), body mass index (BMI), and the state of physical activity in Halabja’s public employees. Overall 355 adults aged from 19 to 63 including 246 males and 109 females contributed to the study. The lipid profiles were tested in all subjects after over-night fasting. In addition, anthropometry measurements were taken; the mean height for males is 1.7129 m and 1.5732 m for females. The mean weights of males and females are 80.4813 and 69.9459 kg, respectively. The mean BMI value for males and females is 27.4258 and 28.3274, respectively. Some of the cases were diagnosed with diabetes, renal diseases, hypertension, and other relevant diseases. 246 of participants adopted sedentary lifestyles while 109 of them lived an active lifestyle. 65, 162, 98, and 206 of participants had TC, TG, LDL-C, and HDL-C off-limits, respectively. Pearson’s correlation between BMI with TC, TG, and LDL-C showed a significant relationship at 0.01 level as 0.156**, 0.140**, and 0.144**, respectively. HDL-C was negatively correlated to BMI at −0.062 level. The analysis of variance showed statistically significant p-values between TC, TG, and HDL-C according to BMI at 0.027, 0.000, and 0.000, respectively. The sedentary group of participants showed a higher Mean range of TC, TG, LDL-C, and HDL-C than an active group of participants.

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Section: Discussionmentioning

confidence: 99%

Association of Lipid Profile with Body Mass Index in Public Employees in Halabja City, Kurdistan Region of Iraq

et al. 2020

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“…This might contribute to a higher prevalence of dyslipidemia 6 in FH +, in addition to the known increased risk of dyslipidemia possessed by having a family history of diabetes. 1,2 FH+ was independently associated with microvascular complications (retinopathy and neuropathy), but not with any ASCVD. In line with previous studies, FH+ was associated with retinopathy and neuropathy but not with DKD [7][8][9][10] ; and that family history of CAD or stroke were stronger predictors for ASCVD than family history of diabetes.…”

mentioning

confidence: 86%

“…Indeed, we noticed that FH+ patients in our study tended to drink alcohol and smoke in comparison to those in FH− groups. This might contribute to a higher prevalence of dyslipidemia 6 in FH+, in addition to the known increased risk of dyslipidemia possessed by having a family history of diabetes 1,2 …”

Section: Characteristics All Subjects (N = 1011) Fh+ (N = 251) Fh− (N...mentioning

confidence: 99%

“…Family history of diabetes (FH+) has been associated with early metabolic alteration including insulin resistance, lipid metabolism, and ectopic fat accumulation even in healthy individuals. 1 , 2 , 3 Furthermore, normoglycemic first‐degree relatives of type 2 diabetes mellitus (T2DM) have been documented having increased carotid intima‐media thickness and pro‐inflammatory cytokines. 4 , 5 Taken together, individuals with FH+, who were otherwise healthy, have shown to possess susceptibility for diabetes mellitus (DM) chronic complication.…”

Section: Tablementioning

confidence: 99%

“…This might contribute to a higher prevalence of dyslipidemia 6 in FH+, in addition to the known increased risk of dyslipidemia possessed by having a family history of diabetes. 1 , 2 …”

Section: Tablementioning

confidence: 99%

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Hypercholesterolemia as the first manifestation of metabolic abnormalities in normoglycemic young adult male with family history of type 2 diabetes mellitus

Cited by 4 publications

References 11 publications

Association of Lipid Profile with Body Mass Index in Public Employees in Halabja City, Kurdistan Region of Iraq

Association of Lipid Profile with Body Mass Index in Public Employees in Halabja City, Kurdistan Region of Iraq

Chronic complications risk among type 2 diabetes patients with a family history of diabetes

Dysregulation of adipokines levels among healthy first-degree relatives of type 2 diabetes patients

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