Hypercholesterolemia is a Potential Risk Factor for Asthma

Al-Shawwa, Baha; Al‐Huniti, Nidal; Titus, Gregory; Abu-Hasan, Mutasim

doi:10.1080/02770900600567056

Cited by 86 publications

(70 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been suggested that leptin might be involved in the pathogenesis of asthma in overweight children and that interferon-c might be a pathway in the process of leptin-induced inflammation [33,34]. A more recent study indicated a higher prevalence of asthma in children with high serum cholesterol [35]. The study was very small (n5188) and has not yet been reproduced.…”

Section: Discussionmentioning

confidence: 71%

Asthma and comorbid medical illness

Cazzola¹,

Calzetta²,

Bettoncelli³

et al. 2010

Eur Respir J

104

View full text Add to dashboard Cite

Asthma is associated with several comorbidities but the magnitude of the association has not been clearly defined. We aimed to examine the relationship between asthma and comorbidities using information obtained from the Health Search Database (HSD) owned by the Italian College of General Practitioners (Società Italiana Medici Generici, Florence, Italy).We conducted a population-based retrospective study using information obtained from the HSD. The software system used codes of all the diagnostic records using the 9th revision of the International Classification of Diseases.Asthma appeared to be weakly associated with cardiovascular and hypertensive diseases. Intriguingly, the odds ratio of acute or old myocardial infarction was 0.84 (95% CI 0.77-0.91). Asthma was also weakly associated with depression, diabetes mellitus, dyslipidaemia, osteoporosis and rhinosinusitis. In contrast, it was strongly associated with gastro-oesophageal reflux disease (GORD) and, particularly, allergic rhinitis. Age did not influence the association of asthma with comorbidities whereas sex had a different impact according to the specific comorbidity.Our results indicate that asthma is weakly associated with several comorbidities, whereas its association with allergic rhinitis or GORD is stronger.

show abstract

Section: Discussionmentioning

confidence: 71%

Asthma and comorbid medical illness

Cazzola¹,

Calzetta²,

Bettoncelli³

et al. 2010

Eur Respir J

104

View full text Add to dashboard Cite

show abstract

“…Some epidemiologic studies suggest that waist circumference-defined abdominal adiposity, one of the characteristics of the metabolic syndrome, is more strongly associated with prevalent asthma than is BMI-defined obesity (7,8). This has led to some authors suggesting that the association of BMI-defined obesity with asthma may be mediated by the metabolic syndrome (9)(10)(11)(12). It is also not known whether the metabolic syndrome overall or its individual components are stronger predictors for incident asthma than BMI.…”

mentioning

confidence: 96%

Body Mass Index Is a Stronger Predictor than the Metabolic Syndrome for Future Asthma in Women. The Longitudinal CARDIA Study

Assad

Qualls

Smith

et al. 2013

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Rationale: It is hypothesized that the metabolic syndrome explains the association between body mass index (BMI) and asthma in adults. Objectives: Our objective was to longitudinally compare the relative strengths of the associations of the metabolic syndrome and BMI with incident asthma in adults. Methods: We included 4,619 eligible participants in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort followed over 25 years. Incident asthma was defined by a new self-reported provider asthma diagnosis plus either the presence of asthma symptoms and/or use of asthma medications. Cox proportional hazard analyses were performed. Measurements and Main Results: Six hundred two subjects (417 women and 185 men) developed incident asthma over 25 years of follow-up. Metabolic syndrome predicted incident asthma among women but not men (unadjusted hazard ratios, 1.50 and 0.98; P ¼ 0.01 and 0.93, respectively). BMI had a similar predictive association among women but not men (unadjusted hazard ratios, 1.19 and 1.04 per 5 units of BMI; P , 0.001 and 0.60, respectively). The association of metabolic syndrome with incident asthma in women was no longer statistically significant after adjustment for BMI (P ¼ 0.44). In contrast, the association of BMI with incident asthma in women remained statistically significant after adjusting for the metabolic syndrome (P ¼ 0.01). In a stepwise model, BMI was a stronger predictor than the metabolic syndrome (P ¼ 0.001). Conclusions: BMI is a stronger predictor of incident asthma among women than the metabolic syndrome. Other obesity-associated factors that are not a part of the metabolic syndrome may play a role in the BMI-asthma association in women.Keywords: incident asthma; metabolic syndrome; body mass index Obesity and asthma are chronic diseases that have increased in prevalence across the world over the last 2 decades (1, 2). During the period 2009 to 2010, 1 in 12 American adults had asthma, and more than one-third of American adults were obese (3, 4). Obesity, as defined by elevated body mass index (BMI) of 30 kg/m 2 or more, is a risk factor for asthma, particularly among women. The basis for this association, however, remains unclear. The metabolic syndrome, as defined by the third Adult Treatment Panel (ATP-III) criteria (5), includes the presence of any three of the following five traits: abdominal adiposity (waist circumference . 102 cm in men and . 88 cm in women), hypertriglyceridemia (>150 mg/dl or drug treatment for high triglycerides), low high-density lipoprotein (HDL) cholesterol levels (,40 mg/dl in men and ,50 mg/dl in women or drug treatment for low HDL), elevated blood pressure (>130/85 mm Hg or drug treatment for elevated blood pressure), and impaired fasting blood glucose or diabetes mellitus (>100 mg/dl or antidiabetic drug treatment) (6). Some epidemiologic studies suggest that waist circumference-defined abdominal adiposity, one of the characteristics of the metabolic syndrome, is more strongly associated with prevalent asthma than is BMI-defined...

show abstract

“…Recently, asthma has been associated with insulin resistance, 22 dyslipidemia, 23,24 and metabolic syndrome, 25 measures of metabolic dysregulation that develop in some but not all obese children. 26,27 Moreover, genetic and epigenetic differences in molecules involved in metabolic dysregulation and its associated inflammation have been found in the context of obesityrelated asthma.…”

Section: Mechanisms Linking Obesity and Asthmamentioning

confidence: 99%

Pediatric Obesity-Related Asthma: The Role of Metabolic Dysregulation

2016

View full text Add to dashboard Cite

The burden of obesity-related asthma among children, particularly among ethnic minorities, necessitates an improved understanding of the underlying disease mechanisms. Although obesity is an independent risk factor for asthma, not all obese children develop asthma. Several recent studies have elucidated mechanisms, including the role of diet, sedentary lifestyle, mechanical fat load, and adiposity-mediated inflammation that may underlie the obese asthma pathophysiology. Here, we review these recent studies and emerging scientific evidence that suggest metabolic dysregulation may play a role in pediatric obesity-related asthma. We also review the genetic and epigenetic factors that may underlie susceptibility to metabolic dysregulation and associated pulmonary morbidity among children. Lastly, we identify knowledge gaps that need further exploration to better define pathways that will allow development of primary preventive strategies for obesity-related asthma in children.

show abstract

Hypercholesterolemia is a Potential Risk Factor for Asthma

Abstract: Hypercholesterolemia is a potential risk factor for asthma independent of obesity.

Cited by 86 publications

References 21 publications

Asthma and comorbid medical illness

Asthma and comorbid medical illness

Body Mass Index Is a Stronger Predictor than the Metabolic Syndrome for Future Asthma in Women. The Longitudinal CARDIA Study

Pediatric Obesity-Related Asthma: The Role of Metabolic Dysregulation

Contact Info

Product

Resources

About