Hypercoagulable states and central retinal vein occlusion

Lahey, J. Michael; Kearney, John J.; Tunç, Murat

doi:10.1097/00063198-200309000-00008

Cited by 47 publications

(31 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…214 Moreover, retinal venous and arterial occlusions are known to be associated with hypertension, diabetes mellitus and hypercoagulability or hyperviscosity syndromes. 122,157,162,214 In addition to the known associations of obesity with hypertension and diabetes, several reviews have presented some evidence supporting the association of hypercoagulability disorders with obesity and metabolic syndrome. 3, 151 This provides further support for the possible association between obesity and retinal vascular occlusive diseases.…”

Section: Obesity and Other Eye Diseasesmentioning

confidence: 99%

Obesity and Eye Diseases

Cheung¹,

Wong²

2007

Survey of Ophthalmology

309

217

View full text Add to dashboard Cite

The prevalence of obesity has reached epidemic proportions in many countries. While its impact on overall health is well documented, less is known about the ocular manifestations of obesity. Amongst different eye diseases, obesity has been linked with age-related cataract, glaucoma, age-related maculopathy, and diabetic retinopathy. Numerous population-based and prospective studies support an association between obesity and risk of age-related cataract. However, the nature and strength of these associations, particularly with the different cataract subtypes, remains to be determined. There is strong evidence that obesity is associated with elevated intraocular pressure, but there is no convincing data to support a more direct association between obesity and glaucomatous optic neuropathy. Studies to date have not found a consistent pattern of association between obesity and risk of age-related maculopathy or diabetic retinopathy. Thus, while obesity may be a risk factor for many ocular conditions, the present literature is inadequate to establish any convincing associations. Furthermore, whether weight loss reduces the risk of eye diseases remains unresolved. Because of the potential public health impact of obesity, there is a greater need to understand its ocular effects.

show abstract

Section: Obesity and Other Eye Diseasesmentioning

confidence: 99%

Obesity and Eye Diseases

Cheung¹,

Wong²

2007

Survey of Ophthalmology

309

217

View full text Add to dashboard Cite

show abstract

“…On individual examination of each of these, 36 fitted the inclusion criteria for tHcy. 10 -12,17-24,27,28,30,32,40 -60 The remaining 11 articles were meta-analyses, 7,16 review articles, 61 commentaries/ letters, 62,63 case reports, 64 -69 or series. On closer examination, 2 articles were duplicate publications of the same dataset, 48,57 whereas a further 9 articles did not present the data in a suitable format that could be used for meta-analysis, 41,42,46,47,49 -51,55,56 for example, presenting the tHcy data as percentage of the population with elevated levels 41,42,50 or not reporting tHcy concentrations or variance in a control groups.…”

Section: Total Homocysteinementioning

confidence: 99%

Homocysteine, Methylenetetrahydrofolate Reductase C677T Polymorphism, and Risk of Retinal Vein Occlusion: A Meta-analysis

McGimpsey¹,

Woodside²,

Cardwell³

et al. 2009

Ophthalmology

View full text Add to dashboard Cite

Objective: To assess the role of plasma total homocysteine (tHcy) concentrations and homozygosity for the thermolabile variant of the methylenetetrahydrofolate reductase (MTHFR) C677T gene as risk factors for retinal vascular occlusive disease.Design: Retinal vein occlusion (RVO) is an important cause of vision loss. Early meta-analyses showed that tHcy was associated with an increased risk of RVO, but a significant number of new studies have been published.Participants and/or Controls: RVO patients and controls. Methods: Data sources included MEDLINE, Web of Science, and PubMed searches and searching reference lists of relevant articles and reviews. Reviewers searched the databases, selected the studies, and then extracted data. Results were pooled quantitatively using meta-analytic methods.Main Outcome Measures: tHcy concentrations and MTHFR genotype.Results: There were 25 case-control studies for tHcy (1533 cases and 1708 controls) and 18 case-control studies for MTHFR (1082 cases and 4706 controls). The mean tHcy was on average 2.8 mol/L (95% confidence interval [CI], 1.8 -3.7) greater in the RVO cases compared with controls, but there was evidence of between-study heterogeneity (PϽ0.001, I2 ϭ 93%). There was funnel plot asymmetry suggesting publication bias. There was no evidence of association between homozygosity for the MTHFR C677T genotype and RVO (odds ratio [OR] 1.20; 95% CI, 0.84 -1.71), but again marked heterogeneity (P ϭ 0.004, I 2 ϭ 53%) was observed. Conclusions: There was some evidence that elevated tHcy was associated with RVO, but not homozygosity for the MTHFR C677T genotype. Both analyses should be interpreted cautiously because of marked heterogeneity between the study estimates and possible effect of publication bias on the tHcy findings.Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

show abstract

“…Among the parameters tested, hyperhomocysteinemia (HHcys) and circulating antiphospholipid antibodies are reported to be significantly more common in the patients with CRVO [3]. Boyd et al [4] have reported that there is no significant increase in factor VIII (von Wilbrand factor), apart from homocysteine (Hcys) levels in the CRVO cases compared with the control subjects.…”

Section: Introductionmentioning

confidence: 99%