Hypercortisolism affects glomerular and tubular function in dogs

Smets, Pascale; Lefebvre, HP; Kooistra, H.S.; Meyer, Evelyne; Croubels, Siska; Maddens, Bart; Vandenabeele, Sophie; Saunders, Jimmy; Daminet, Sylvie

doi:10.1016/j.tvjl.2011.05.027

Cited by 32 publications

(32 citation statements)

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“…Retinol binding protein (RBP) is filtered through the renal glomeruli because of its low molecular weight and is reabsorbed in the proximal tubules under physiological circumstances (Christensen et al, 1999). Therefore, increased urinary RBP (uRBP) indicates tubular dysfunction, as previously reported in dogs with E. coli pyo met ra, C KD , and Cushing's syndrome Smets et al, 2010b;Smets et al, 2011).…”

mentioning

confidence: 63%

“…Glomerular damage consequently leads to the urinary presence of these HMW proteins. Urinary IgG (uIgG) and/or urinary CRP (uCRP) detected glomerular dysfunction in dogs with Escherichia coli pyometra, chronic kidney disease (CKD), and Cushing's syndrome Smets et al, 2010b;Smets et al, 2011). Retinol binding protein (RBP) is filtered through the renal glomeruli because of its low molecular weight and is reabsorbed in the proximal tubules under physiological circumstances (Christensen et al, 1999).…”

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confidence: 99%

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Assessment of renal dysfunction using urinary markers in canine babesiosis caused by Babesia rossi

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Schoeman

Smets

et al. 2012

Veterinary Parasitology

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Renal damage is deemed a common, yet poorly documented, complication in canine babesiosis.Serum urea and creatinine are insensitive and non-specific markers of early renal dysfunction and 2 their measurements are influenced by hemolysis caused by babesiosis. Therefore, the aim of this study was to use urinary markers to assess the localization and degree of renal dysfunction in dogs with Babesia rossi infection. Urinary immunoglobulin G (uIgG) and urinary C-reactive protein (uCRP) were measured as markers for glomerular dysfunction, while urinary retinol-binding protein (uRBP) was used as a marker for tubular dysfunction. Eighteen dogs presenting with uncomplicated babesiosis were included and compared with eight clinically healthy dogs. Previously validated commercial ELISA kits were used for the measurement of uIgG, uCRP, and uRBP. Results were related to urinary creatinine concentrations (c). Dogs with babesiosis had significantly higher concentrations of all three measured urinary markers compared to healthy dogs. Except for urinary protein/c ratio (UPC), routine urinary and serum markers for renal function (urine specific gravity (USG), serum urea and creatinine (sCr)) were not significantly different between dogs with babesiosis and healthy dogs.All three urinary markers were positively correlated with each other and with UPC. The data supports the presence of both glomerular and tubular dysfunction in dogs suffering from uncomplicated B. rossi infection. Urinary markers were superior to USG, serum urea and creatinine concentrations for the early detection of renal dysfunction in dogs with babesiosis.

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confidence: 63%

mentioning

confidence: 99%

Assessment of renal dysfunction using urinary markers in canine babesiosis caused by Babesia rossi

Defauw

Schoeman

Smets

et al. 2012

Veterinary Parasitology

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“…The 6 out of 9 dogs with HAC (#1, #2, #3, #5, #6 and #8) were non-proteinuric (UPC <1.0), showing that any evident renal damage developed. For those non-proteinuric dogs evaluated by UPC, probably the renal damage may not developed because of the short period of follow-up, as well as because of the time course of the disease, or it could be related to therapy with trilostane that may have prevented to the progression of glomerular injury or glomerular hyperfiltration, which could indicate that the therapy may have met benefits to avoid glomerular lesions (Waters et al 1997, Smets et al 2012b, another evidence that the treatment decreased glomerular filtration rate values are found in the serum creatinine, which increased throughout the treatment. However, UPC solely does not predict the segment of the nephron affected that caused the loss of proteins in the urine.…”

Section: Resultsmentioning

confidence: 99%

“…Waters et al (1997) indicated that the immunosuppressive effects and glomerular hypertension may be associated with the cause of the renal proteinuria. It seems that chronic hypercortisolemia increases glomerular filtration rate (GFR) and, thereafter, increases glomerular membrane permeability, leading to glomerular injury (Smets et al 2012b).…”

Section: Introductionmentioning

confidence: 99%

“…Thus currently, four mechanisms have been described to trigger renal proteinuria in dogs with chronic hypercortisolemia, and it includes: (1) changing in glomerular capillary permeability, (2) increase in tubular secretion of proteins, (3) decrease in tubular reabsorption of proteins and (4) the excess of volume filtration that allows the passage of large amounts of proteins through the glomerulus that overlaps the capacity of tubular reabsorption (Smets et al 2010(Smets et al , 2012b(Smets et al , 2012c.…”

Section: Introductionmentioning

confidence: 99%

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Urine protein electrophoresis study in dogs with pituitary dependent hyperadrenocorticism during therapy with trilostane

et al. 2017

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RESUMO.-[Avaliação da proteína urinária por eletroforese em cães com hiperadrenocorticismo hipófise dependente durante a terapia com trilostano.] Hiperadrenocorticismo (HAC) é uma das doenças endócrinas mais comuns em cães. A hipercortisolemia crônica pode causar danos glomerulares, pelo aumento da taxa de filtração glomerular, podendo levar ao desenvolvimento de doença renal crônica. Este estudo avaliou nove cães normotensos com hiperadrenocorticismo hipófise-dependente, antes e após a terapia com trilostano, durante o período de acompanhamento de seis meses, a fim de investigar o desenvolvimento de proteinúria patológica por métodos quantitativo (relação proteína e creatinina urinária) e qualitativos (eletroforese de proteínas urinárias) e também para monitorar a sua intensidade ao longo do curso da doença e terapia. A principal lesão renal detectada em cães com HAC foi no segmento tubular, evidenciada pela prevalência de bandas de proteínas urinárias de peso molecular mais baixo, indicando a falta de absorção destas proteínas no segmento proximal do néfron. A proteinúria de baixo peso molecular persistiu durante todo o acompanhamento. Em relação ao futuro da rotina clínica médica veterinária no tratamento de cães com hiperadrenocorticismo, as avaliações de proteinúria pela relação proteína e creatinina urinária e eletro- Hyperadrenocorticism is one of the most common endocrine disorders in dogs. Regarding to the kidneys, chronic hypercortisolemia can cause damage to the glomerulus, and evolve into chronic kidney disease. This study evaluated nine normotensive dogs with pituitary dependent hyperadrenocorticism, before and after therapy with trilostane, during the follow-up period of six months, in order to investigate the development of pathological proteinuria by quantitative (urinary protein-to-creatinine ratio) and qualitative (urinary protein electrophoresis) methods, and also to monitor its intensity over the course of the disease and therapy. The main renal lesion detected in dogs with hyperadrenocorticism was in the tubular segment, evidenced by the prevalence of urinary protein bands of lower molecular weight, indicating the lack absorption of these proteins in the proximal segment of the nephron. Low molecular weight proteins persisted throughout the follow-up. Regarding the future of routine veterinary medical clinic in the care of patients with hyperadrenocorticism, the assessments of proteinuria determinations by the urinary protein-to-creatinin ratio and urinary protein electrophoresis, according to the results obtained in this study, can add more information about the renal damage in these animals, and contribute to the prognosis. 735 Urine protein electrophoresis study in dogs with pituitary dependent hyperadrenocorticism during therapy with trilostane forese de proteínas urinárias, de acordo com os resultados obtidos neste estudo, podem adicionar mais informações sobre a lesão renal nestes animais e contribuir para o prognóstico.

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Proteinuria

2023

Urinalysis in the Dog and Cat

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Hypercortisolism affects glomerular and tubular function in dogs

Cited by 32 publications

References 11 publications

Assessment of renal dysfunction using urinary markers in canine babesiosis caused by Babesia rossi

Assessment of renal dysfunction using urinary markers in canine babesiosis caused by Babesia rossi

Urine protein electrophoresis study in dogs with pituitary dependent hyperadrenocorticism during therapy with trilostane

Proteinuria

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