Hyperdry Human Amniotic Membrane as a Protective Dressing for Open Wounds With Exposed Bowel in Mice

Amano, Koji; Okabe, Motonori; Yoshida, Toshiko; Oba, Jiro; Yoshida, Satoshi; Wakasugi, Masahiro; Usui, Akihiro; Nakata, Yasuki; Okudera, Hiroshi

doi:10.1016/j.jss.2022.09.028

Journal of Surgical Research

2023

DOI: 10.1016/j.jss.2022.09.028

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Hyperdry Human Amniotic Membrane as a Protective Dressing for Open Wounds With Exposed Bowel in Mice

Koji Amano

Motonori Okabe²,

Toshiko Yoshida³

et al.

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2023

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Establishment and evaluation of an improved rat model of open abdomen

Liu,

Li,

Huang

et al. 2023

Anim Models and Exp Med

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IntroductionThis study aimed to establish an animal model of open abdomen (OA) through temporary abdominal closure via different techniques.MethodsAdult male Sprague–Dawley rats were randomly divided into three groups: group A (OA with polypropylene mesh alone); group B (OA with polypropylene mesh combined with a patch); and group C (OA with polypropylene mesh and a sutured patch). Vital signs, pathophysiological changes, and survival rates were closely monitored in the rats for 7 days after surgery. Abdominal X‐rays and histopathological examinations were performed to assess abdominal organ changes and wound healing.ResultsThe results showed no significant difference in mortality rates among the three groups (p > 0.05). However, rats in group B exhibited superior overall condition, cleaner wounds, and a higher rate of wound healing compared to the other groups (p < 0.05). Abdominal X‐rays indicated that varying degrees of distal intestinal obstruction in all groups. Histopathological examinations revealed fibrous hyperplasia, inflammatory cell infiltration, neovascularization, and collagen deposition in all groups. Group B demonstrated enhanced granulation tissue generation, neovascularization, and collagen deposition compared to the other groups (p < 0.05).ConclusionsPolypropylene mesh combined with patches is the most suitable method for establishing an animal model of OA. This model successfully replicated the pathological and physiological changes in postoperative patients with OA, specifically the progress of abdominal skin wound healing. It provides a practical and reliable animal model for OA research.

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Establishment and evaluation of an improved rat model of open abdomen

Liu,

Li,

Huang

et al. 2023

Anim Models and Exp Med

View full text Add to dashboard Cite

show abstract

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Hyperdry Human Amniotic Membrane as a Protective Dressing for Open Wounds With Exposed Bowel in Mice

Cited by 1 publication

References 41 publications

Establishment and evaluation of an improved rat model of open abdomen

Establishment and evaluation of an improved rat model of open abdomen

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