Hyperemesis gravidarum and cardiometabolic risk factors in adolescents: a follow‐up of the Northern Finland Birth Cohort 1986

Koot, Marjette H.; Grooten, Iris J.; Sebért, Sylvain; Koiranen, Markku; Jarvelin, Marjo-Riita; Kajantie, Eero; Painter, Rebecca C.; Roseboom, Tessa J.

doi:10.1111/1471-0528.14534

Cited by 13 publications

(13 citation statements)

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“…(13)(14)(15)(16) None of these studies found differences in offspring lipid concentrations in childhood. (13)(14)(15)(16) Two studies however, did find that offspring born to women with HG were heavier and more adipose in childhood than offspring born to women without HG, (14,16) which can in line lead to increased Apo-B levels in later life, and therefore affect offspring cardiovascular disease risk. (43) Taking our findings into account, differences in these studies' findings might be due to differences in HG severity with studies including women with a more severe HG being more likely to find associations than studies including women with a relatively mild HG.…”

Section: Discussionmentioning

confidence: 97%

“…(12) In the limited literature available on the topic of long term effects of HG on offspring, a wide range of HG definitions and outcomes were employed, and little information was collected on the role of maternal nutrition. (13)(14)(15)(16) This is of particular relevance as nutritional supplementation is not generally included in HG clinical management plans. (17) The role of maternal nutrition in HG, or the role of HG disease severity on offspring health in later life has not been investigated, nor has the ability of nutritional supplementation to amend such effects.…”

Section: Introductionmentioning

confidence: 99%

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Hyperemesis gravidarum severity, enteral tube feeding and cardiometabolic markers in offspring cord blood

et al. 2022

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The present study aimed to investigate the association between hyperemesis gravidarum (HG) severity and the effect of early enteral tube feeding on cardiometabolic markers in offspring cord blood. We included women admitted for HG, who participated in the MOTHER randomized controlled trial (RCT) and observational cohort. The MOTHER RCT showed that early enteral tube feeding in addition to standard care did not affect symptoms or birth outcomes. Among RCT and cohort participants, we assessed how HG severity affected lipid, c-peptide, glucose and free thyroxine cord blood levels. HG severity measures were: severity of vomiting at inclusion and three weeks after inclusion, pregnancy weight gain and 24-hour energy intake at inclusion, readmissions and duration of hospital admissions. Cord blood measures were also compared between RCT participants allocated to enteral tube feeding and those receiving standard care. Between 2013-2016, 215 women were included: 115 RCT and 100 cohort participants. Eighty-one cord blood samples were available. Univariable, not multivariable regression analysis showed that lower maternal weight gain was associated with higher cord blood glucose levels (β:−0.08, 95% CI:−0.16;-0.00). Lower maternal weight gain was associated with higher apolipoprotein-B cord blood levels in multivariable regression analysis (β:−0.01, 95% CI:−0.02;−0.01). No associations were found between other HG severity measures or allocation to enteral tube feeding and cord blood cardiometabolic markers. In conclusion, while lower maternal weight gain was associated with higher apolipoprotein-B cord blood levels, no other HG severity measures were linked with cord blood cardiometabolic markers, nor were these markers affected by enteral tube feeding.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Hyperemesis gravidarum severity, enteral tube feeding and cardiometabolic markers in offspring cord blood

et al. 2022

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“…The psychological distress appears to be self-limiting in tandem with symptoms of HG [3]. Koot and colleagues (2017) [25] examined physical data in an attempt to predict whether BMI affected the HG phenomenon, but found no significant proof. However, they did show that suffering from HG would affect the pregnant woman's BMI, whether by gaining very little weight or no weight at all during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with hyperemesis gravidarum

Keren,

Ayala

2020

Clin. Exp. Obstet. Gynecol.

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Introduction: Nausea and Vomiting of Pregnancy (NVP) is a common health condition during pregnancy, often referred to as 'morning sickness'. The most severe degree is Hyperemesis Gravidarum (HG). The reasons for this phenomenon are still somewhat unclear. Methods: The sample included 201 fertility-age women, who had experienced at least one pregnancy. Data were gathered by a questionnaire that included sociodemographic questions and validated questionnaires: BSI, anxiety state and anxiety trait. Results: A relationship was found between existing gastrointestinal disorders and HG, and anxiety state and HG. Logistic regression significantly showed that previous gastrointestinal disorders predicted HG. Discussion: It seems that the emotional state and physical condition are related to HG, and that women with gastrointestinal diseases are more likely to suffer from HG.

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“…7 For the male fetus, association with an increase in premature risk and neonatal morbidity is found. 33 It should be noted that the percentage of HG incidence in female and male fetuses didn't show a significant difference. 19,28,31,33 There is an association between HG and a heavier weight of the placenta compared with birth weight.…”

Section: Incidence a N D Risk Factorsmentioning

confidence: 92%

“…There was no association between HG and the longterm mortality of the fetus, as well as the risk of cardiovascular disease during adolescence. 33,40 In conclusion, HG is a complex, multifactorial condition with many potential etiological factors. 39…”

Section: Incidence a N D Risk Factorsmentioning

confidence: 99%

Hyperemesis Gravidarum: A Holistic Review and Approach to Etiopathogenesis, Clinical Diagnostic and Management Therapy

Simanjuntak¹,

Andrian²,

Wibowo³

et al. 2016

Journal of South Asian Federation of Obstetrics and Gynaecology

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Aim:To provide an overview of hyperemesis gravidarum (HG) and to present possible links between factors associated with the pathogenesis of HG also the effectiveness and safety of the nonpharmacologic and pharmacologic options available to treat HG. Background: Although HG incidence is 0.3-2% worldwide, it is the number one cause of hospitalization in the first-trimester pregnancy, costs greatly to one financially, and also reduces the quality of life. This literature review focuses on articles published over the last 7 years to examine current perspectives and recent developments in HG. Review results: Nausea and vomiting are common symptoms during early pregnancy. When vomiting is severe, it is referred to as HG. Despite its high prevalence, it tends to be underestimated. The etiopathogenesis remains unknown, but many risk factors have been determined. Currently, the therapy focused on improving the symptoms while minimizing risks to the mother and fetus. If HG is left untreated, it may lead to significant maternal morbidity and adverse birth outcomes. Conclusion: Hyperemesis gravidarum is a complex and multifactorial condition. The incidence is higher in developing countries rather than in developed countries. Hyperemesis gravidarum can manifest as mild to severe signs and symptoms. The therapy ranges from dietary and lifestyle changes, intravenous fluid rehydration, hospitalization, nonpharmacologic, and pharmacologic treatment. Hyperemesis gravidarum can result as a mild to severe maternal and fetal complications.

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Hyperemesis gravidarum and cardiometabolic risk factors in adolescents: a follow‐up of the Northern Finland Birth Cohort 1986

Abstract: Hyperemesis gravidarum does not affect cardiometabolic health in adolescent offspring.

Cited by 13 publications

References 36 publications

Hyperemesis gravidarum severity, enteral tube feeding and cardiometabolic markers in offspring cord blood

Hyperemesis gravidarum severity, enteral tube feeding and cardiometabolic markers in offspring cord blood

Factors associated with hyperemesis gravidarum

Hyperemesis Gravidarum: A Holistic Review and Approach to Etiopathogenesis, Clinical Diagnostic and Management Therapy

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