Hyperemesis Gravidarum and Fetal Outcome

Paauw, James D.; Bierling, Sandra; Cook, Curtis R.; Davis, Alan T.

doi:10.1177/014860710502900293

Cited by 54 publications

(49 citation statements)

References 22 publications

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“…Several studies have found similar and slightly higher reductions in birthweight. 6,8,[18][19][20] Other studies have not found a similar association.…”

Section: Discussionmentioning

confidence: 84%

Hyperemesis gravidarum and birth outcomes—a population‐based cohort study of 2.2 million births in the Norwegian Birth Registry

Vandraas

Vikanes

Vangen

et al. 2013

BJOG

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Objective To study associations between hyperemesis gravidarum (HG) and birth outcomes.Design Population-based cohort study.Setting Norway.Sample Singleton births in the Norwegian Birth Registry, 1967-2009 (n = 2 270 363).Methods Multiple logistic regression was applied to study associations between HG and dichotomous outcomes; multiple linear regression to study associations between HG, birthweight and gestational length. Generalised estimating equations were applied to obtain valid standard errors. Sub-analysis on data with available information on smoking was conducted (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)).Main outcome measures Small and large for gestational age (SGA/LGA), Apgar score after 5 minutes, very preterm and preterm birth (VPTB/PTB), perinatal death, stillbirth, neonatal death, birthweight and gestational length.Results No associations between HG and adverse pregnancy outcomes were observed in crude analyses, except for VPTB (odds ratio [OR] 0.79, 95% CI 0.67-0.93). In adjusted analysis, HG was associated with perinatal death (OR 1.27, 95% CI 1.08-1.48). Inverse associations were observed between HG and VPTB (OR 0.80, 95% CI 0.68-0.94) and LGA (OR 0.95, 95% CI 0.90-0.99). Sub-analyses showed no associations between HG and perinatal death (OR 1.29, 95% CI 0.91-1.83). The inverse associations between HG, VPTB and LGA were strengthened (OR 0.66, 95% CI, respectively). Exposed babies had reduced birthweight and gestational length compared with unexposed, adjusted difference À 21.4 g and À 0.5 days, respectively. Adjustment for smoking slightly strengthened the impact of HG on birthweight.Conclusions Inverse associations for HG and VPTB and LGA were observed. HG was associated with slight reductions in birthweight and gestational age.

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“…Several studies have found similar and slightly higher reductions in birthweight. 6,8,[18][19][20] Other studies have not found a similar association.…”

Section: Discussionmentioning

confidence: 84%

Hyperemesis gravidarum and birth outcomes—a population‐based cohort study of 2.2 million births in the Norwegian Birth Registry

Vandraas

Vikanes

Vangen

et al. 2013

BJOG

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“…In contrast, other studies reported that just women with HG gaining less than 7 kg during pregnancy had a risk for PTB, LBW and increase in risk for a 5 minute Apgar score < 7 [7] .…”

Section: Introductionmentioning

confidence: 76%

“…HG has been reported to be associated with low birth weight (LBW), preterm birth (PTB), small-for gestational-age (SGA), perinatal mortality and prolonged stay in hospital for the new-born infant [7][8][9] . In contrast, other studies reported that just women with HG gaining less than 7 kg during pregnancy had a risk for PTB, LBW and increase in risk for a 5 minute Apgar score < 7 [7] .…”

Section: Introductionmentioning

confidence: 99%

Hyperemesis gravidarum and early new-born outcomes

2017

Evidence Based Women's Health Journal

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Background: Hyperemesis gravidarum (HG) represents a more severe degree of nausea and vomiting of pregnancy and is potentially lethal if not treated well. HG is defined as persisting nausea and vomiting leading to dehydration, weight loss and nutritional deficiencies and was reported to be associated with poor perinatal outcome. Aim: To evaluate the effect of HG on the perinatal outcome. Patients and Methods: The study was conducted at Suez Canal University Hospitals, Ismailia at outpatient clinic from October 2015 to January 2017. 132 patients were selected with evidence of HG, the study group, and 137 women with no evidence of HG were the control group. Preterm birth, low birth weight, Apgar score <7 at 5 minutes of birth and perinatal mortality were the studied outcome measures. Results:The Apgar score at 5 minutes of birth was the only outcome showed significant difference between the both groups (P value <0.001) while other mentioned perinatal outcomes were of insignificant difference. Also such significant difference in the Apgar score was more related to the maternal weight gain. Conclusion: Apgar score at 5 minutes of birth could be affected by HG if associated with poor maternal weight gain.

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“…Symptoms range from mild to severe. Patients may present with weight loss exceeding 5% of their body weight, dehydration, ke- (9,10). Mild hyperthyroidism may be associated with HG, perhaps due to high serum concentrations of human chorionic gonadotropin, which may have more thyroid-stimulating activity in pregnant women (11).…”

Section: Clinical Featuresmentioning

confidence: 99%