Hyperemesis Gravidarum in Eastern Asian Population

Matsuo, Koji; Ushioda, Norichika; Nagamatsu, Masaaki; Kimura, Tadashi

doi:10.1159/000106493

Cited by 40 publications

(38 citation statements)

References 10 publications

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“…The incidence of HG was 1.6 %, which is lower than the 3.6 % incidence reported by the latest study in the general Japanese population [4], but within the range of 0.3–2.0 % reported by other studies [1–3]. In addition, the participants in our study reported an incidence of NVP of 10.2 %, which is lower than the 33 % incidence reported by Chortatos et al [22]; the difference is likely related to the fact that we defined NVP based on self-reported accounts of reduced food intake.…”

Section: Discussioncontrasting

confidence: 54%

“…There is a high incidence of nausea and vomiting in early pregnancy (NVP), reported at 35–91 % [1–4]. NVP can become severe in 0.3–3.6 % of cases, with hyperemesis gravidarum (HG) as an extreme form of NVP that is associated with weight loss [1–4].…”

Section: Introductionmentioning

confidence: 99%

“…NVP can become severe in 0.3–3.6 % of cases, with hyperemesis gravidarum (HG) as an extreme form of NVP that is associated with weight loss [1–4]. The incidence of HG varies by country, and was reported at nearly 3.6 % in Japan [4]. …”

Section: Introductionmentioning

confidence: 99%

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Relationship between hyperemesis gravidarum and small-for-gestational-age in the Japanese population: the Japan Environment and Children’s Study (JECS)

Morokuma

Shimokawa

Kato

et al. 2016

BMC Pregnancy Childbirth

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BackgroundSmall-for-gestational-age in infancy is a known risk factor not only for short-term prognosis but also for several long-term outcomes, such as neurological and metabolic disorders in adulthood. Previous research has shown that severe nausea and vomiting in early pregnancy (NVP) and hyperemesis gravidarum, which is an extreme form of NVP, represent risk factors for small-for-gestational-age birth. However, there is no clear consensus on this association. Thus, in the present study, we investigated the correlation between hyperemesis gravidarum and NVP on the one hand, and infant birth weight on the other, using data from the Japan Environment and Children’s Study (JECS).MethodsThe data utilized in the present study were obtained from the JECS, an ongoing cohort study that began in January 2011. Our sample size was 8635 parent–child pairs. The presence or absence of severe NVP, hyperemesis gravidarum, and potential confounding factors were noted. A multivariable regression analysis was used to estimate risks for small-for-gestational-age birth, and the results were expressed as risk ratios and 95 % confidence intervals.ResultsThe risk ratios of small-for-gestational-age birth (95 % confidence interval) for mothers with severe NVP and those with hyperemesis gravidarum were 0.86 (0.62–1.19) and 0.81 (0.39–1.66), respectively, which represents a non-significant result.ConclusionsIn our analysis of JECS data, neither severe NVP nor hyperemesis gravidarum was associated with increased risk for small-for-gestational-age birth.

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Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

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Relationship between hyperemesis gravidarum and small-for-gestational-age in the Japanese population: the Japan Environment and Children’s Study (JECS)

Morokuma

Shimokawa

Kato

et al. 2016

BMC Pregnancy Childbirth

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“…It is associated with numerous physiological implications to the mother such as dehydration, electrolyte imbalances and extreme weight loss, and concerns regarding outcomes of babies born to women with HG have repeatedly been raised (Fejzo et al 2009). Maternal genotype or ethnicity may play a major role in its pathogenesis and one group reports an increased incidence of HG in the East Asian population (Matsuo et al 2011). It still remains elusive whether such diff erences can be attributed to genetic factors related to ethnicity aff ecting outcomes in women with HG, or whether they could be a result of cultural diff erences aff ecting reporting of symptomology.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes in severe hyperemesis gravidarum in a multi-ethnic population

Vlachodimitropoulou-Koumoutsea

Gosh

Manmatharajah

et al. 2013

Journal of Obstetrics and Gynaecology

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We evaluated pregnancy outcomes among women with hyperemesis gravidarum (HG) in a North London multi-ethnic population. A retrospective case-control study was performed on records of obstetric admissions during a 4-year period, at North Middlesex University Hospital in North London. A total of 208 women with HG were identified according to Fairweather's criteria occurring in the first 20 weeks of pregnancy, which is severe enough to require admission to hospital. The control study group consisted of 208 women without HG, matched for age, ethnicity and parity. Maternal characteristics as well as pregnancy outcomes were compared in the two groups. The incidence of a delivery of a small-for-gestational-age (SGA) neonate below the 10th per centile was significantly higher in the HG group compared with unaffected pregnancies (8.7% vs 16.8%, p = 0.01). Hyperemesis gravidarum in a multi-ethnic population in North London is associated with SGA neonates.

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“…For example, a Malaysian study identified 192 recorded cases (3.9%) out of 4937 maternities [9]. Additionally, a study of 3350 singleton deliveries in an Eastern Asian population observed HG in 119 (3.6%) of the population [10]. As mentioned, a study of 1867 singleton live births revealed the highest rate of severe nausea and vomiting of pregnancy in Shanghai, China, from 1986 to 1987, with an incidence of 10.8%.…”

Section: Introductionmentioning

confidence: 99%

Familial aggregation of hyperemesis gravidarum

Zhang

Cantor

MacGibbon

et al. 2011

American Journal of Obstetrics and Gynecology

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Objective This study was undertaken to determine whether there is familial aggregation of Hyperemesis Gravidarum making it a disease amenable to genetic study. Study Design Cases with severe nausea and vomiting in a singleton pregnancy treated with intravenous hydration and unaffected friend controls completed a survey regarding family history. Results Sisters of women with Hyperemesis Gravidarum have a significantly increased risk of having Hyperemesis Gravidarum themselves (OR=17.3, p=0.005). Cases have a significantly increased risk of having a mother with severe nausea and vomiting; 33% of cases reported an affected mother compared to 7.7% of controls (p<.0001). Cases reported a similar frequency of affected second-degree maternal and paternal relatives (18% maternal lineage, 23% paternal lineage). Conclusion There is familial aggregation of Hyperemesis Gravidarum. This study provides strong evidence for a genetic component to hyperemesis gravidarum. Identification of the predisposing gene(s) may determine the cause of this poorly understood disease of pregnancy.

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Hyperemesis Gravidarum in Eastern Asian Population

Cited by 40 publications

References 10 publications

Relationship between hyperemesis gravidarum and small-for-gestational-age in the Japanese population: the Japan Environment and Children’s Study (JECS)

Relationship between hyperemesis gravidarum and small-for-gestational-age in the Japanese population: the Japan Environment and Children’s Study (JECS)

Pregnancy outcomes in severe hyperemesis gravidarum in a multi-ethnic population

Familial aggregation of hyperemesis gravidarum

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