Hyperferritinemia as a Marker of Still's Disease

Adult-onset still's disease

“…Myalgia, abdominal pain, splenomegaly, pericarditis, pleuritis and pneumonitis were found to be less common compared with the other series (2,6,7,9–11) (Table 1). Hepatomegaly and splenomegaly were frequent findings seen in 50% of the patients.…”

Successful treatment with plasma exchange in adult-onset Still’s disease with hyper-IL-18-naemia and hyperallergic state

“…This patient with AOSD presented with an extremely high serum ferritin level and severe liver dysfunction. Hyperferritinaemia ([1,000 ng/mL), which is also seen in variety of inflammatory conditions, is not specific; however, extremely high concentrations ([10,000 ng/mL) are rare [6] and are specific for AOSD [7,8]. A long period was required for the patient to recover after the three drugs found to be positive on DLST had been stopped.…”

Bilateral Empyema Caused by Adult-Onset Still’s Disease

“…Excluding the setting of clinical syndromes associated with iron overload (liver disease, transfusions, sickle cell disorders), elevated serum ferritin levels are considered a nonspecific marker for a variety of significant disorders, including renal disease, malignancy, HIV infection and non-HIV systemic infections [13]. However, in the presence of compatible clinical findings, serum ferritin levels ≥3,000 µg/l add support to a diagnosis of AOSD [14]. Indeed, in the study of Yamaguchi et al [15], 20 out of 30 patients with AOSD demonstrated hyperferritinemia 4 times greater than normal limits (sensitivity 67% and specificity 85% when compared to other inflammatory disorders).…”