Hyperferritinemia worsens the perinatal outcomes of conceptions of pregnancies with preeclampsia

Silva, João Victor Farias da; Ferreira, Raphaela Costa; Tenório, Marilene Brandão; Tenório, Micaely C.S.; Silveira, Jonas Augusto Cardoso da; Amaral, Andrea Costa Morais; Goulart, Marília Oliveira Fonseca; Moura, Fabiana Andréa; Oliveira, Alane Cabral Menezes de

doi:10.1016/j.preghy.2019.11.004

Cited by 9 publications

(4 citation statements)

References 30 publications

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“…This small number did not enable us to further specify the association between high ferritin levels and the different causes of PTB (spontaneous and iatrogenic PTB). High ferritin levels have been associated with (worsening of) preeclampsia, higher incidence of PPROM, premature contractions, and IUGR 16,34–40 . Additionally, we were unable to further stratify for parity in the multiparous group, due to low power.…”

Section: Discussionmentioning

confidence: 96%

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High first trimester ferritin levels differ according to parity and are independently related to preterm birth: A prospective cohort study

Broekhuis,

Koenen,

Broeren

et al. 2024

Acta Obstet Gynecol Scand

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IntroductionA considerable amount of neonatal morbidity and mortality worldwide is caused by preterm birth. To date, the underlying etiology of preterm birth has not been fully clarified. Previous studies demonstrate that inflammation is one of the pathological factors that might cause preterm birth, and that there is a difference between primiparous and multiparous women in immune response to pregnancy. The objective of this prospective cohort study was to investigate the role of two inflammatory markers, ferritin and C‐reactive protein (CRP) and preterm birth, in first trimester women, stratified for parity. In addition, a possible association between high ferritin and CRP, and a possible association between high ferritin and CRP and preterm birth were assessed.Material and methodsA total of 2044 healthy, low‐risk pregnant women from primary obstetric care in the Netherlands participated in this study. Their ferritin and CRP levels were evaluated at 12 weeks’ gestation. Levels above the parity specific 95th percentile were defined as high. The main outcome of this study was to assess the presence of a possible association between parity specific high ferritin and CRP, and preterm birth. The secondary outcomes were the ferritin and CRP levels of women, stratified for parity, and the possible association between high ferritin and CRP levels.Logistic regression analysis was performed with preterm birth as a dependent variable and parity specific high ferritin and CRP as an independent variable, adjusting for age and history of preterm birth.ResultsFerritin levels decreased with increasing parity. Ferritin and CRP levels at 12 weeks’ gestation were significantly higher in women with preterm birth. In primiparous women, high ferritin levels (OR: 2.5, CI: 1.14–5.38) and high CRP levels (OR: 5.0, CI: 2.61–9.94) were independently associated with preterm birth. In multiparous women, high ferritin levels (OR: 6.0, CI: 2.28–16.67) were independently associated with preterm birth while high CRP levels were not.ConclusionsFirst trimester parity specific ferritin and CRP levels could play a part in predictive models for preterm birth, and further research for their additive role in preterm birth is needed.

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Section: Discussionmentioning

confidence: 96%

“…High ferritin levels have been associated with (worsening of) preeclampsia, higher incidence of PPROM, premature contractions, and IUGR. 16,[34][35][36][37][38][39][40] Additionally, we were unable to further stratify for parity in the multiparous group, due to low power.…”

Section: Discussionmentioning

confidence: 99%

High first trimester ferritin levels differ according to parity and are independently related to preterm birth: A prospective cohort study

Broekhuis,

Koenen,

Broeren

et al. 2024

Acta Obstet Gynecol Scand

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“…Требуется осторожность в оценке ЖДС и назна чении препаратов железа у женщин с преэклампсией, у которых повышены уровень сывороточного железа, ферритина, гепсидина и сатурация трансферрина [54]. Рутинное назначение препаратов железа пациенткам с преэклампсией может стимулировать перегрузку железом, вызвать окислительный стресс, эндотелиаль ную дисфункцию и ухудшить состояние матери и пло да [55,56].…”

Section: во время беременностиunclassified

Perioperative iron deficiency anemia in obstetrics. Possibilities of prevention and correction. Review

Kulikov

Shifman

Matkovsky

et al. 2020

Annals of Critical Care

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In the review diagnostics and correction of iron deficiency anemia (IDA) is considered during pregnancy and in the perioperative period within the concept of “patient blood management”. Features of diagnosis of anemia and verification of an iron deficiency (ID) are discussed during pregnancy, correction stages with use of oral and intravenous iron, transfusion erythrocytes and reinfusion of blood. Data on advantage of intravenous iron to correction of ID and IDA are provided during pregnancy and in the perioperative period.

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“…Another serological marker of inflammation widely used in the monitoring of COVID-19 is ferritin. Ferritin elevation in pregnant women with COVID-19 is a frequent laboratory finding, especially in severe cases [7][8][9]. Regarding the analysis of coagulopathies in COVID-19, one of the main markers used is the D-dimer.…”

Section: Introductionmentioning

confidence: 99%

Association of D-Dimer, C-Reactive Protein, and Ferritin with COVID-19 Severity in Pregnant Women: Important Findings of a Cross-Sectional Study in Northern Brazil

Paixão

Santos

França

et al. 2023

IJERPH

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Background: The COVID-19 pandemic has had a great impact on pregnant women due to the broad clinical spectrum of the disease. The present study investigated the profile of three biomarkers during hospital admission of pregnant women—D-dimer, C-reactive protein (CRP), and ferritin—and their correlation with the severity and outcome of COVID-19. Methods: The cross-sectional study included 226 pregnant women hospitalized in the city of Belém, Pará, Northern Brazil, from April 2020 to July 2021. Epidemiological and laboratory data were obtained from medical records, and all pregnant women underwent RT-PCR molecular testing for the detection of SARS-CoV-2. Results: In total, 121 (53.5%) were positive and 105 (46.5%) were negative for SARS-CoV-2 using RT-PCR. Most pregnant women (49.5%) with COVID-19 were between 26 and 34 years old, were residing in the interior of the state of Pará (51.2%), and were in the third gestational trimester (71.9%). In addition, 71.1% of them were admitted to the ward and 28.9% were admitted to the intensive care unit (ICU), with 90.9% surviving COVID-19. The concentrations of D-dimer (p = 0.0122) and ferritin (p ≤ 0.0001) were significantly higher among pregnant women with COVID-19, especially among those hospitalized in the ICU. Conclusion: Ferritin and D-dimer seem to serve as important biomarkers for the prognosis of COVID-19 in pregnant women, which was not observed for CRP.

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Hyperferritinemia worsens the perinatal outcomes of conceptions of pregnancies with preeclampsia

Cited by 9 publications

References 30 publications

High first trimester ferritin levels differ according to parity and are independently related to preterm birth: A prospective cohort study

High first trimester ferritin levels differ according to parity and are independently related to preterm birth: A prospective cohort study

Perioperative iron deficiency anemia in obstetrics. Possibilities of prevention and correction. Review

Association of D-Dimer, C-Reactive Protein, and Ferritin with COVID-19 Severity in Pregnant Women: Important Findings of a Cross-Sectional Study in Northern Brazil

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