Hyperfibrinogenemia as a Risk Factor for Sudden Hearing Loss

Suckfüll, M.; Wimmer, Christoph; Reichel, Oliver; Mees, K.; Schorn, K.

doi:10.1097/00129492-200205000-00013

Cited by 71 publications

(75 citation statements)

References 10 publications

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“…Other works instead, on the basis of fibrinogen rheological properties, highlighted the association between high fibrinogen levels and reduced blood flow in the inner ear with major risk of SSNHL onset (Suckfull et al, 2002;Canis et al, 2012;Bao et al 2015). Quaranta et al (2015) did not find any significant difference in terms of fibrinogen level between patients with and without hearing improvement (p ¼ 0.22).…”

Section: Discussionmentioning

confidence: 99%

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Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Salvago

Rizzo

Bianco

et al. 2016

International Journal of Audiology

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Objective: To investigate the relationship between haematological routine parameters and audiogram shapes in patients affected by sudden sensorineural hearing loss (SSNHL). Design: A retrospective study. All patients were divided into four groups according to the audiometric curve and mean values of haematological parameters (haemoglobin, white blood cell, neutrophils and lymphocytes relative count, platelet count, haematocrit, prothrombin time, activated partial thromboplastin time, fibrinogen and neutrophil-to-lymphocite ratio) of each group were statistically compared. The prognostic role of blood profile and coagulation test was also examined. Study sample: A cohort of 183 SSNHL patients without comorbidities. Results: With a 48.78% of complete hearing recovery, individuals affected by upsloping hearing loss presented a better prognosis instead of flat (18.36%), downsloping (19.23%) and anacusis (2.45%) groups (p ¼ 0.0001). The multivariate analysis of complete blood count values revealed lower mean percentage of lymphocytes (p ¼ 0.041) and higher platelet levels (p ¼ 0.015) in case of downsloping hearing loss; with the exception of fibrinogen (p ¼ 0.041), none of the main haematological parameters studied resulted associated with poorer prognosis. Conclusions: Our work suggested a lack of association between haematological parameters and a defined audiometric picture in SSNHL patients; furthermore, only fibrinogen seems to influence the prognosis of this disease.

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Section: Discussionmentioning

confidence: 99%

“…Additionally, rheological and thrombophilic factors like high plasma viscosity, elevated fibrinogen levels, inherited prothrombotic conditions (e.g. hyperhomocysteinemia, Factor V Leiden mutation) and reduced erythrocyte filterability may increase the risk of SSNHL onset (Suckfull et al, 2002;Fusconi et al, 2012;Lovato et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Salvago

Rizzo

Bianco

et al. 2016

International Journal of Audiology

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“…pure tone average -PTA), które były podstawą do rozpoznania niedosłuchu. Wartości graniczne PTA powyżej których rozpoznawano niedosłuch nie były jednolite i w zależności od ośrodka, w którym przeprowadzono badania wynosiły od 15 do 30 dB [46,65,107,110,204]. Część autorów w swoich doniesieniach nie podawała w ogóle tej wartości [99,115,166,241].…”

Section: Metody Badań Narządu S ł Uchu I Równowagi U Chorych Z Udaunclassified

“…Wzrost lub spadek ciśnienia krwi oraz zwężenie światła naczynia są wymieniane wśród czynników etiopatogenetycznych zarówno udaru jak i nagłej głuchoty. Tylko niektórzy autorzy potwierdzają zależność między występowaniem niedosłuchu czuciowo-nerwowego a obecnością nadciśnienia tętniczego [54,204,205]. Inni autorzy nie stwierdzają takich zależności [49,68].…”

Section: 5 Potencjały Wywołane Pnia Mózgu (Abr)unclassified

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Stan słuchu u chorych we wczesnym okresie udaru niedokrwiennego mózgu

Przewoźny¹

2007

Otolaryngologia Polska

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Improved treatment of sudden hearing loss by specific fibrinogen aphaeresis

Ullrich

Kleinjung

Steffens

et al. 2004

J of Clinical Apheresis

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The etiology of sudden sensorineural hearing loss is still unclear and is thought to result from disturbances of microcirculation, infectious causes, or autoimmune disorders. So far standard therapy did not show clear improvement over spontaneous remission rate, which is assumed to be about 50% [Nakashima et al., Acta. Otolaryngol. Stockh. 514:14-16, 1994; Schuknecht and Donovan, Arch. Otorhinolaryngol. 243:1-15, 1986; Harris and Sharp, Laryngoscope 100:516-524, 1990; Mayot et al., Clin. Immunol. Immunopath. 68:41-45, 1993; Gussen, Ann. Otol. Rhinol. Laryngol. 85:94-100, 1976]. Elevated blood viscosity due to high fibrinogen levels is supposed to cause decreased cochlear blood flow and thus initiate sudden hearing loss. The specific lowering of fibrinogen immediately decreases plasma viscosity exactly to the desired extent and should lead to improved cochlear blood flow [Suckfüll et al., Acta. Otolaryngol 119:763-766, 1999; Suckfüll, Lancet 360:1811-1817, 2002; Walch et al., Laryngol. Rhino. Otol. 75:641-645, 1996; Suckfüll et al., Otol. Neurotol. 23:309-311, 2002]. In a prospective uncontrolled pilot study on 36 patients with unilateral sudden onset sensorineural hearing loss (SHL) we tried to establish that 1-3 specific fibrinogen aphaereses alone improve recovery of hearing and that it is possible to lower fibrinogen to the target of 80-100 mg/dl without important side effects. Pure tone audiometry was carried out immediately before and after each aphaeresis as well as at 2 and 4 weeks and 6 months after treatment. Sixteen patients recovered spontaneously before undergoing fibrinogen adsorption. All 20 aphaeresis patients improved during immunoadsorption; in 60% of patients auditory thresholds returned to normal after the first immunoadsorption and treatment could be discontinued, in another 20% of patients complete recovery was reached after 4 weeks. The mean plasma fibrinogen concentration of the 20 patients before the first aphaeresis session was 308.1 +/- 51.5 mg/dl. Immediately after the first treatment session, the fibrinogen concentration was lowered to 100.7 +/- 25.3 mg/dl (P < 0.001). The second and third sessions also showed highly significant reductions in plasma fibrinogen. No important side effects were seen. In conclusion, specific fibrinogen adsorption is a promising new treatment modality that should be tested in a prospective, randomized controlled trial in patients with sudden hearing loss.

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Hyperfibrinogenemia as a Risk Factor for Sudden Hearing Loss

Cited by 71 publications

References 10 publications

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Stan słuchu u chorych we wczesnym okresie udaru niedokrwiennego mózgu

Improved treatment of sudden hearing loss by specific fibrinogen aphaeresis

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