Hyperfractionated radiotherapy with concurrent chemotherapy for para-aortic lymph node recurrence in carcinoma of the cervix

Kim, Jun-Sang; Kim, Jae-Sung; Kim, Samyong; Kim, K.i-Hwan; Cho, Moon-June

doi:10.1016/s0360-3016(02)04401-2

Cited by 40 publications

(32 citation statements)

References 21 publications

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“…Some authors suggested the use of serum SCC assay, in addition to CT scan or MR imaging, in the followup of patients with advanced disease and elevated antigen level at the time of diagnosis [53]. An isolated para-aortic recurrence can occur in 2.1-3.6% of cervical cancer patients, being more common in those with advanced disease, and some of these can survive for a long period after salvage radiotherapy or chemo-radiation [53][54][55][56][57][58]. About one-third of patients have symptoms at relapse, mainly represented by lumbago or lower extremity oedema, which are associated with a worse prognosis [53].…”

Section: Serum Scc Assay In the Monitoring Of Response To Treatment Amentioning

confidence: 99%

The serum assay of tumour markers in the prognostic evaluation, treatment monitoring and follow-up of patients with cervical cancer: A review of the literature

Gadducci

Tana

Cosio

et al. 2008

Critical Reviews in Oncology/Hematology

138

127

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Section: Serum Scc Assay In the Monitoring Of Response To Treatment Amentioning

confidence: 99%

The serum assay of tumour markers in the prognostic evaluation, treatment monitoring and follow-up of patients with cervical cancer: A review of the literature

Gadducci

Tana

Cosio

et al. 2008

Critical Reviews in Oncology/Hematology

138

127

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“…To reduce toxicity, the extent of the radiation field should be considered. Elective irradiation usually covers the entire para-aortic region (29,(32)(33)(34)(35)(36), but the irradiated field has been reduced in several studies (30,37). Yeo et al (30) maintained a 5-cm margin above and below the GTV for the CTV and reported an 18% (4 of 22 patients) para-aortic failure rate outside the RT field.…”

Section: Discussionmentioning

confidence: 99%

“…Intraoperative radiotherapy has benefits in that it can achieve high dose of radiation without increasing toxicity, but surgical morbidity, mortality, and inconvenience should be considered. Several studies involving 3D-CRT or IMRT techniques have been performed (29,30,(36)(37)(38). The maximum radiation dose in these studies was 61.2 Gy with 1.8 Gy  Y.-S. Seo et al…”

Section: Discussionmentioning

confidence: 99%

Stereotactic Body Radiotherapy for Oligometastases Confined to the Para-Aortic Region: Clinical Outcomes and the Significance of Radiotherapy Field and Dose

Seo

Kim

Cho

et al. 2015

Cancer Investigation

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We retrospectively reviewed 88 patients with oligometases in the para-aortic region from any controlled primary tumor site who were treated with stereotactic body radiotherapy (SBRT). The 5-year local control, disease-free survival, and overall survival rates were 83%, 31%, and 41%, respectively. A 90% tumor-control probability was predicted at a biological effective dose of 90 Gy. Severe gastrointestinal toxicities (grade ≥3) were observed in 2 of 88 patients (1%). The results of this study are limited by the retrospective nature of the study but could serve as the background and rationale for future prospective trials on SBRT-based treatment for oligometastses.

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“…For example, Kim et al [27] treated 12 patients with isolated para-aortic lymph node recurrence. The fractionated dose was 1.2 Gy in 2 daily fractions, and the median total dose was 60 Gy.…”

Section: Treatment Of Local Pelvic Recurrencementioning

confidence: 99%

State-of-the-Art Treatment and Novel Agents in Local and Distant Recurrences of Cervical Cancer

Tempfer

Beckmann²

2016

Oncol Res Treat

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Depending on the stage at initial presentation, cervical cancer will recur in 25-61% of women. Typical manifestations of recurrent cervical cancer include the central pelvis and the pelvic side walls as well as retroperitoneal lymph node basins in the pelvis and the para-aortic region, and - more rarely - supraclavicular lymph nodes. There are no typical symptoms of recurrent cervical cancer. Women with suspected recurrence after cervical cancer based on gynecological examination or organ-specific symptoms must undergo imaging studies and - if technically feasible - biopsy with histological verification, especially in cases of distant metastases, in order to rule out a second primary. Radiotherapy-naïve women should be treated with salvage radiochemotherapy with curative intention. For women with previous radiotherapy, surgery in the form of hysterectomy, local resection, or pelvic exenteration is the treatment of choice. Pelvic exenteration can lead to cure in selected patients, but at the price of a high rate of complications and significant morbidity and mortality. If complete surgical resection is not feasible or if the woman is not a candidate for surgery, chemotherapy with palliative intent should be offered. Patients with recurrent disease outside the pelvis are candidates for systemic chemotherapy. Several agents have shown to be active in this situation, either in single-agent or combination regimens. Platinum-containing regimens have a superior efficacy over non-platinum regimens and bevacizumab may be added to chemotherapy.

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Hyperfractionated radiotherapy with concurrent chemotherapy for para-aortic lymph node recurrence in carcinoma of the cervix

Cited by 40 publications

References 21 publications

The serum assay of tumour markers in the prognostic evaluation, treatment monitoring and follow-up of patients with cervical cancer: A review of the literature

The serum assay of tumour markers in the prognostic evaluation, treatment monitoring and follow-up of patients with cervical cancer: A review of the literature

Stereotactic Body Radiotherapy for Oligometastases Confined to the Para-Aortic Region: Clinical Outcomes and the Significance of Radiotherapy Field and Dose

State-of-the-Art Treatment and Novel Agents in Local and Distant Recurrences of Cervical Cancer

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