Hyperfunction of neutrophils in a patient with BCR/ABL negative chronic myeloid leukemia

Sweet's syndrome with hematologic disorders: a review and reappraisal

“…Both exogenous administration 15 and endogenously elevated levels are implicated 13 . This may be mediated, in part, by increased neutrophilic sensitivity to and release by paracrine and autocrine mechanisms of IL‐8 16 . This “disruption” in the cytokine network is also putatively attributed to elevated levels of IL‐6 and can be seen with concurrently normal levels of IL‐1 and γ‐interferon 16,17 …”

“…This may be mediated, in part, by increased neutrophilic sensitivity to and release by paracrine and autocrine mechanisms of IL‐8 16 . This “disruption” in the cytokine network is also putatively attributed to elevated levels of IL‐6 and can be seen with concurrently normal levels of IL‐1 and γ‐interferon 16,17 Increased neutrophil maturation and/or trafficking in the dermis due to elevated levels of exogenous drug administration: all‐trans retinoic acid, 51 G‐CSF, 15 imatinib, 52 and bortezomib 53 .…”

“…Included in these neutrophilic dermatoses are pyoderma gangrenosum, neutrophilic eccrine hidradenitis, erythema elevatum diutinum, and Behcet's disease. It is likely that the pathophysiology of AND lies in a disequilibrium of neutrophil generation, maturation and activation secondary to imbalances in cytokine levels 12–18 . As Robert Sweet observed in his seminal paper, “it seems likely that the condition is a reaction to something ...” 3 …”

Association of non‐alcoholic steatohepatitis (NASH) with chronic neutrophilic leukemia

“…Recently, Watari et al . (14) reported remarkably increased production of superoxide and IL‐8, which are inducers of positive chemotaxis of neutrophils, in a case of BCR/ABL‐negative CML. Furthermore, malignant CML cells carry a functional membrane nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and are thus capable of producing reactive oxygen species (ROS) (15).…”