Hypergastrinemia induced by glucocorticoid and corticotropin treatment in man

Abstract

To elucidate further the pathogenesis of steroid-induced ulceration, plasma gastrin levels, both basal and after a test meal, were studied in normal volunteers and patients treated with glucocorticoids or corticotropin. In normal subjects the acute intravenous administration of 100 mg prednisolone had no effect on plasma gastrin levels. After oral administration of prednisolone (40 mg daily, for four days) a significant increase of the basal, the reactive, and the over 90-min integrated gastrin release was observed. In this group, the glucocorticoid treatment had a slight, but significant influence on gastric acid and pepsin secretion, while acidity and pepsin output stimulated by pentagastrin was not affected. In patients treated with prednisolone for more than 24 weeks, the oral administration of this hormone failed to alter basal gastrin values but affected significantly secretion after the test meal. In patients with multiple sclerosis, after intramuscular administration of corticotropin (60 IU daily, for 12 days), an increase of the basal, the reactive, and the integrated gastrin release also was found. Glucocorticoid-induced hypergastrinemia provides information on the pathogenesis of steroid-induced ulceration.

Role of the serum and glucocorticoid inducible kinase SGK1 in glucocorticoid stimulation of gastric acid secretion

“…The present observations provide evidence for an involvement of SGK1 in the regulation of gastric acid secretion [14,42].…”

Effect of glucocorticoids on gastrin secretion in man.

“…andRaptis et al (1976) reported that a bolus injection of glucocorticoids did not increase plasma gastrin, although four to…”

“…Accumulating evidence in recent years has suggested that gastrin is an important ulcerogenic factor among gastrointestinal hormones (Trudeau et al, 1970;Gedde-Dahl, 1974;Walsh et al, 1975). To our knowledge, however, very few studies have been reported on the effect of glucocorticoids on gastrin secretion (Watson et al, 1973;Giordano and Marugo, 1974;Raptis et al, 1976).…”

Glucocorticoid Suppression of Pancreatic and Pituitary Hormones: Pancreatic Polypeptide, Growth Hormone, and Prolactin*

“…Basal and stimulated gastrin secretion have been shown to be stimulated by glucocorticoids (10), and a similar effect on pancreatic glucagon has been reported (8). The association of glucocorticoid excess with diminished carbohydrate tolerance is well known; supranormal insulin concentrations occur consistently, even when carbohydrate tolerance is well maintained (11).…”