Hyperglycaemia is associated with impaired muscle signalling and aerobic adaptation to exercise

MacDonald, Tara; Pattamaprapanont, Pattarawan; Pathak, Prerana; Fernandez, Natalie; Freitas, Ellen Cristini de; Hafida, Samar; Mitri, Joanna; Britton, Steven L.; Koch, Lauren G.; Lessard, Sarah J.

doi:10.1038/s42255-020-0240-7

Cited by 42 publications

(53 citation statements)

References 72 publications

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“…Somewhat surprisingly, mice with hyperglycaemia exhibited elevated GLUT4 muscle levels and improved glucose tolerance with training. As noted by MacDonald, this hints that ‘metabolic improvements with exercise are dissociated from improvements in exercise capacity’ ( MacDonald et al, 2020 ), which raises the possibility that exercise-induced improvements in glucose metabolism might reduce the burden of low improvements in aerobic capacity. Future work in this area will be of great interest.…”

Section: Resultsmentioning

confidence: 94%

“…Building on evidence that has linked low exercise capacity and hyperglycaemia, MacDonald et al evaluated whether chronic hyperglycaemia–specifically consumption of a ‘western diet’ or the induction of experimental diabetes—impacted exercise-induced improvements in aerobic capacity and skeletal muscle remodelling in rodents. This study revealed that exercise-induced improvements in aerobic capacity and associated skeletal muscle remodelling were impaired in models associated with chronic hyperglycemia ( MacDonald et al, 2020 ). This ground-breaking study further identified a signalling network that is aberrantly activated by aerobic exercise in rodents with hyperglycaemia (and also humans).…”

Section: Resultsmentioning

confidence: 99%

“…This ground-breaking study further identified a signalling network that is aberrantly activated by aerobic exercise in rodents with hyperglycaemia (and also humans). This involved both glucose-mediated modifications of the extracellular matrix and altered JNK-signalling in muscle ( MacDonald et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

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Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease?

Bowman

Smith

Gould

2021

PeerJ

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The global incidence, associated mortality rates and economic burden of diabetes are now such that it is considered one of the most pressing worldwide public health challenges. Considerable research is now devoted to better understanding the mechanisms underlying the onset and progression of this disease, with an ultimate aim of improving the array of available preventive and therapeutic interventions. One area of particular unmet clinical need is the significantly elevated rate of cardiomyopathy in diabetic patients, which in part contributes to cardiovascular disease being the primary cause of premature death in this population. This review will first consider the role of metabolism and more specifically the insulin sensitive glucose transporter GLUT4 in diabetic cardiac disease, before addressing how we may use exercise to intervene in order to beneficially impact key functional clinical outcomes.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

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Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease?

Bowman

Smith

Gould

2021

PeerJ

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“…When the results of this study were examined, it was seen that Zumba exercises caused a significant decrease in glucose level. Previous research also indicated that aerobic exercises reduced blood glucose levels [34][35][36].…”

Section: Discussionmentioning

confidence: 91%

Effects of 8-week zumba exercise on blood lipids profile in sedentary women

Turgut

Soylu

2021

ppcs

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Background and Study Aim. Different aerobic exercise may affect women’s health behaviours. Therefore, this study aimed to determine the effect of 8-week Zumba exercises applied to sedentary women on lipid profile. Material and Methods. Fifty voluntary healthy sedentary women with a mean age of 32.1 ± 6.8 years and a mean height of 158.4 ± 15.5 cm participated in the study. Before and after the exercise program, blood samples and body weight were taken on before breakfast in the morning by experts in the appropriate laboratory environment, some environmental measurements. In the analysis of the data, the SPSS 22.0 package program was used to compare the pre-post exercise values (Paired Sample T-Test) as well as descriptive statistics. The effect sizes (Cohen's d) were calculated to provide the estimation of the comparisons between the pre-test and post-test results of the obtained values. Results. According to the results, it was determined that there were significant differences between blood lipids Glucose, Urea, Triglyceride, total High-Density Lipoprotein Cholesterol (HDL-C) and Low-Density Lipoprotein Cholesterol (LDL-C) levels before and after Zumba exercise program (p <0.05). In addition, it was determined that there was a significant and positive change between the pre-test and post-test BMI values (p <0.05). Conclusions. According to the results of the study, it was concluded that the 8-week Zumba exercise program applied to sedentary women had a positive effect on the lipid profiles of women.

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“…During the past decade, a rising number of promising articles (e.g., Agudelo et al, 2014;Pedersen et al, 2016;Takahashi et al, 2019;Brett et al, 2020;MacDonald et al, 2020) uncovered different metabolic mechanisms of exercise in animal models, which are either involved in the alleviation of disease progression (e.g., depression, hyperglycemia, and tumor growth) or reveal novel aspects of metabolism. However, it remains unclear whether these findings are only driven by "exercise-induced" effects or biased by levels of inactivity as they probably occur through housing conditions.…”

Section: Introductionmentioning

confidence: 99%

Talking About Physical “Activity” or “Inactivity”? The Need of Accurate Activity Controlling in Exercise Studies in Rodents

2020

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Hyperglycaemia is associated with impaired muscle signalling and aerobic adaptation to exercise

Cited by 42 publications

References 72 publications

Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease?

Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease?

Effects of 8-week zumba exercise on blood lipids profile in sedentary women

Talking About Physical “Activity” or “Inactivity”? The Need of Accurate Activity Controlling in Exercise Studies in Rodents

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