Hyperglycemia and compositional lipoprotein abnormalities as predictors of cardiovascular mortality in type 2 diabetes: a 15-year follow-up from the time of diagnosis.

Abstract

This long-term study of a well-characterized group of newly diagnosed patients strengthens the view that the prognosis in middle-aged subjects is markedly impaired and that both hyperglycemia and compositional lipoprotein abnormalities are predictors of cardiovascular mortality in patients with type 2 diabetes.

Risk of stroke in people with type 2 diabetes in the UK: a study using the General Practice Research Database

“…This has also been demonstrated in previous studies [1-3, 8, 14, 29, 30]. The risk associated with obesity in people with diabetes was increased only in the group with a BMI >35 kg/m 2 , reflecting perhaps the lack of association between stroke and obesity seen in other smaller studies among people with diabetes [3,9,[11][12][13]. Using BMI <23 kg/m 2 as the reference and grouping as in the Physicians' Health Study [10], where the study population included individuals with diabetes, our study showed a smaller non-significant increase in risk; those with a BMI >30 kg/m 2 had a 40% increased risk compared with 112% in that study (data not shown).…”

“…Although 20% of strokes may be associated with diabetes [1], published risk estimates for stroke associated with diabetes vary from no increased risk [2] to a more than sixfold increase in risk [3]. The increase in risk attributable to diabetes appears to decrease with increasing age [2,[4][5][6].…”

“…Indeed, Wong et al showed that after the age of 75 years, patients with diabetes had the same risk of stroke as those without diabetes [2]. The evidence for an increase in risk with smoking and obesity in people with diabetes is conflicting [3,[7][8][9][10][11][12][13].…”

“…Part of the variation in the published risk estimates for stroke in people with diabetes may be explained by the composition of the study populations [2,3,9,14]. Many studies excluded older patients, did not differentiate between diabetes type, selected from a population that had a different underlying risk of stroke from that of the UK or used the general population containing diabetes as the comparison group [9,10,13,14].…”

Risk of myocardial infarction in men and women with type 2 diabetes in the UK: a cohort study using the General Practice Research Database

“…Many published studies to date were either conducted in a population of one sex only [2,4], included people with type 1 diabetes [3,9,10] (which may affect the risk by age) or were limited to those under the age of 65 [11,12] thereby excluding a measure of risk for patients with the highest prevalence of type 2 diabetes. In addition, many studies were based on comparatively small cohorts from populations with a high underlying risk of MI [13,14] or were selected from secondary care [15] and consequently more likely to have worse disease progression.…”