Hyperglycemia and methylprednisolone: Comment on the article by den Uyl et al

Martínez-Martínez, Marco Ulises; Martínez-Lozano, Jorge Adolfo; Abud-Mendoza, Carlos

doi:10.1002/art.34641

Cited by 2 publications

(2 citation statements)

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“…Even though prolonged exposure to low doses of GC negatively impacts intermediate glucose metabolism (i.e., hepatic insulin-receptor binding), most of the clinical studies with healthy individuals did not result in fasting glycemia greater than 126 mg/dL (7 mM) [ 9 , 17 , 19 , 31 , 35 ]. Although GC therapies must be used with caution, especially in susceptible individuals [ 36 , 37 ], it is important to note that the parameters that were altered in these individuals returned to baseline values after interruption of GC treatment [ 17 ].…”

Section: Effects Of Gc Excess In the Liver: Contribution Of Increamentioning

confidence: 99%

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Impact of Glucocorticoid Excess on Glucose Tolerance: Clinical and Preclinical Evidence

Pasieka

Rafacho

2016

Metabolites

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Glucocorticoids (GCs) are steroid hormones that exert important physiological actions on metabolism. Given that GCs also exert potent immunosuppressive and anti-inflammatory actions, synthetic GCs such as prednisolone and dexamethasone were developed for the treatment of autoimmune- and inflammatory-related diseases. The synthetic GCs are undoubtedly efficient in terms of their therapeutic effects, but are accompanied by significant adverse effects on metabolism, specifically glucose metabolism. Glucose intolerance and reductions in insulin sensitivity are among the major concerns related to GC metabolic side effects, which may ultimately progress to type 2 diabetes mellitus. A number of pre-clinical and clinical studies have aimed to understand the repercussions of GCs on glucose metabolism and the possible mechanisms of GC action. This review intends to summarize the main alterations that occur in liver, skeletal muscle, adipose tissue, and pancreatic islets in the context of GC-induced glucose intolerance. For this, both experimental (animals) and clinical studies were selected and, whenever possible, the main cellular mechanisms involved in such GC-side effects were discussed.

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Section: Effects Of Gc Excess In the Liver: Contribution Of Increamentioning

confidence: 99%

“…However, corroborating studies that have previously addressed this issue with GCs and RA indicated that GC treatment may significantly increase the incidence of T2DM in RA patients [ 106 ]. Thus, individual monitoring is required [ 36 , 37 , 106 ].…”

Section: Effects Of Gc Excess In the Pancreatic Islets: Contributimentioning

confidence: 99%