2016
DOI: 10.1007/s00394-016-1212-2
|View full text |Cite
|
Sign up to set email alerts
|

Hyperglycemia-associated alterations in cellular signaling and dysregulated mitochondrial bioenergetics in human metabolic disorders

Abstract: PurposeThe severity of untreated or refractory diabetes mellitus has been functionally linked to elevated concentrations of free plasma glucose, clinically defined as hyperglycemia. Operationally, the pathophysiological presentations of prolonged hyperglycemia may be categorized within insulin-dependent and insulin-independent, type 1 and type 2 diabetic phenotypes, respectively. Accordingly, major areas of empirical biomedical research have focused on the elucidation of underlying mechanisms driving key cellu… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
78
0
2

Year Published

2017
2017
2021
2021

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 123 publications
(80 citation statements)
references
References 47 publications
0
78
0
2
Order By: Relevance
“…Although a totally new finding in regard to transplanted hiPSC‐derived pancreatic progenitor cells differentiating towards islet cell fates, the ability of hyperglycaemia to drive ROS overproduction was previously described in other contexts . These studies showed that hyperglycaemia is increasing the glucose flux and TCA cycle (Krebs cycle), consequently raising the levels of electron transfer donors (NADH, FADH 2 ) that, in turn, enhance OXPHOS and ROS production .…”
Section: Discussionmentioning
confidence: 96%
See 1 more Smart Citation
“…Although a totally new finding in regard to transplanted hiPSC‐derived pancreatic progenitor cells differentiating towards islet cell fates, the ability of hyperglycaemia to drive ROS overproduction was previously described in other contexts . These studies showed that hyperglycaemia is increasing the glucose flux and TCA cycle (Krebs cycle), consequently raising the levels of electron transfer donors (NADH, FADH 2 ) that, in turn, enhance OXPHOS and ROS production .…”
Section: Discussionmentioning
confidence: 96%
“…Although a totally new finding in regard to transplanted hiPSC-derived pancreatic progenitor cells differentiating towards islet cell fates, the ability of hyperglycaemia to drive ROS overproduction was previously described in other contexts. 42,50,51 These studies showed that hyperglycaemia is increasing the glucose flux and TCA cycle (Krebs cycle), consequently raising the levels of electron transfer donors (NADH, FADH 2 ) that, in turn, enhance OXPHOS and ROS production. 23,52,53 Our analysis was consistent with this scenario revealing a pattern of regulation reflecting the consistent activation of both Glycolysis and OXPHOS in the top activated pathways, regardless of the hyperglycaemia exposure period.…”
Section: Discussionmentioning
confidence: 99%
“…The present clinical and radiographic results are in accordance with previous studies that reported a poorer periodontal status in patients with poorly‐controlled type‐2 DM compared with systemically‐healthy controls. Persistent hyperglycemia (a common manifestation in patients with poorly‐controlled DM) is associated with an increased AGEs‐RAGE interaction that compromises cellular physiology and function, due to a defective constitution of the extracellular matrix . It has also been proposed that under hyperglycemic conditions, AGEs‐RAGE interactions exaggerate the inflammatory host response, augment oral infection and cause resorption of alveolar bone .…”
Section: Discussionmentioning
confidence: 99%
“…ROS production leads to the increase in the formation of advanced glycation end products (AGEs), which can cause activation of a number of proinflammatory pathways, associated with the pathogenesis of cardiovascular complications of diabetes. 1 Glycemic control can decrease the mortality rate by impairing the glycation of lipoproteins, enzymes, and other components of lipid metabolism, and inhibiting AGEs formation. 2,3 Chemical chaperones (such as amino acids, polyols like glycerol and amino compounds like polyamines) are small molecules that can prevent the change in protein structures and functions due to glycation.…”
Section: Introductionmentioning
confidence: 99%