Hyperglycemia induces corneal endothelial dysfunction through attenuating mitophagy

Chen, Chen; Zhou, Qingjun; Li, Zongyi; Liu, Yameng; Wan, Luqin; Wang, Huifeng; Xie, Lixin

doi:10.1016/j.exer.2021.108903

Cited by 12 publications

(9 citation statements)

References 39 publications

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“…Thus, we stipulate that cornea endothelial cells may lie in a sensitive state and are more susceptible to damage under stimulation in patients with DM. Our team preliminarily confirmed that attenuating mitophagy and endoplasmic reticulum stress play important roles in diabetic corneal endothelial dysfunction (34,35). Nevertheless, continued laboratory research is needed to confirm the exact molecular mechanisms involved.…”

Section: A B Cmentioning

confidence: 72%

The effects of acute angle closure crisis on corneal endothelial cells in patients with type 2 diabetes mellitus

Cong

Pan²,

Xia³

et al. 2022

Front. Endocrinol.

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ObjectiveThis study investigated the effects of acute angle closure crisis (AACC) on the corneal endothelial cells in patients with type 2 diabetes mellitus (DM) to identify the factors that cause corneal endothelial cell injury.MethodsWe examined 154 patients who visited Qingdao Eye Hospital for AACC in one eye (154 eyes; 28 men and 126 women; mean age of 68 ± 8 years). We divided the participants into non-DM, DM well-control, and DM poor-control groups, with the unaffected eyes used as controls. Each participant was evaluated at the hospital while under AACC. We measured the relevant index and corneal parameters of the participants for statistical analysis.ResultsThere were significant statistical differences in corneal parameters among the three groups. The decreased levels of central endothelial cell density (CD) and the percentage of hexagonal cells (6A) were statistically relevant among the groups (P<0.05). The AACC duration was correlated with CD loss rate among the groups (P<0.05). The DM duration was correlated with CD loss rate in the DM well-control group. Compared with the non-DM group, the level of 6A decreased more significantly in the DM group after AACC (P<0.05). The AACC duration in the DM well-control group was significantly shorter than in the non-DM and DM poor-control groups (P<0.001). The DM poor-control group showed significantly worse visual acuity when compared with the other groups (P<0.05).ConclusionsDM may impact the functional status of corneal endothelial cells. AACC can worsen the corneal endothelium damage in patients with DM. Blood glucose levels and the duration of intraocular hypertension are closely related to the severity of corneal endothelial injury.

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Section: A B Cmentioning

confidence: 72%

The effects of acute angle closure crisis on corneal endothelial cells in patients with type 2 diabetes mellitus

Cong

Pan²,

Xia³

et al. 2022

Front. Endocrinol.

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Section: Mitophagy Activation By Atherosclerotic Risk Factors In Endo...mentioning

confidence: 99%

“…Vascular risk factor-induced EC injury, dysfunction, or death can be alleviated by mitophagy (C. Chen C et al, 2022 ; Li C et al, 2020 ; Xi et al, 2021 ; Xiang et al, 2022 ). Under risk factors-induced stress, the mitochondria in ECs show dysfunction, including increased ROS production, opening of the mitochondrial permeability transition pore, release of mitochondrial mtDAMPs and other mitochondria-derived peptides, decreased mitochondrial membrane potential and elevated caspase-3/9 activity (C. Chen C et al, 2022 ; Huang et al, 2020 ; Shimada et al, 2012 ; Zheng and Lu, 2020 ). This event ultimately leads to inflammation and damage of the intima, the main cause of atherosclerotic initiation ( Qian et al, 2021 ).…”

Section: Endothelial Mitophagy and Atherosclerosismentioning

confidence: 99%

“…Defective mitophagy is observed in ECs from diabetic rats. High glucose condition reduces mRNA and protein levels of Pink1, Parkin, and LC3B in ECs, suggesting an inhibition of mitophagy (C. Chen C et al, 2022 ; W. Zhu W et al, 2018 ). These studies show that high glucose levels inhibit mitophagy in ECs by reducing the expression levels of ubiquitin-mediated mitophagy proteins.…”

Section: Endothelial Mitophagy and Atherosclerosismentioning

confidence: 99%

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Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis

Fang

Xian

et al. 2022

Front. Physiol.

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The mitochondria are essential organelles that generate large amounts of ATP via the electron transport chain (ECT). Mitochondrial dysfunction causes reactive oxygen species accumulation, energy stress, and cell death. Endothelial mitochondrial dysfunction is an important factor causing abnormal function of the endothelium, which plays a central role during atherosclerosis development. Atherosclerosis-related risk factors, including high glucose levels, hypertension, ischemia, hypoxia, and diabetes, promote mitochondrial dysfunction in endothelial cells. This review summarizes the physiological and pathophysiological roles of endothelial mitochondria in endothelial function and atherosclerosis.

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“…Because of the worldwide increase in DM prevalence [5] and the possible effects of hyperglycemia on corneal dysfunction [12,15,16], measuring anterior-segment parameters in patients with poorly controlled or treatment-naive T2DM could help prospectively monitor the ocular health status of this cohort and compare future cohorts of patients with well-controlled T2DM. Thus, we aimed to evaluate the corneal topography, asphericity, and aberrometry parameters in patients with T2DM and hyperglycemia.…”

Section: Introductionmentioning

confidence: 99%

Corneal topography and higher-order aberrations in patients with type 2 diabetes mellitus

Asharlous¹,

Riazi²,

Jamali³

et al. 2023

Med Hypothesis Discov Innov Optom

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Background: Changes in blood sugar levels cause alterations in the anterior segment and retina of the eye. This study was aimed at evaluating corneal topography, aberrometry, and corneal asphericity in patients with treatment-naive type 2 diabetes mellitus (T2DM). Methods: Participants with treatment-naive T2DM were enrolled in this cross-sectional study. The inclusion criteria were glycated hemoglobin A1c (Hb A1c) greater than or equal to 7.5% and absence of other ocular or systemic diseases. Patients who refused to participate or had a history of topical or systemic steroid use, hyperlipidemia, hypertension, anemia, prior ocular disorder or surgery, diabetic retinopathy, glaucoma, cataract, active ocular inflammatory or infectious disease, or contact lens use were excluded. All participants underwent a comprehensive ophthalmic examination. The Pentacam HR Scheimpflug tomography system (Pentacam High Resolution; Oculus, Wetzlar, Germany) was used to measure the anterior-segment parameters. Results: Sixty eyes of 30 patients with a male-to-female ratio of 1:1 were included; the mean (standard deviation [SD]) age and Hb A1c were 51.63 (6.73) years and 8.82% (1.31%), respectively. The mean (SD) values of central corneal thickness, root mean square (RMS) of total aberration, RMS of lower-order aberrations, RMS of higher-order aberrations, spherical aberration, 0° coma, 90° coma, flat anterior keratometry (K), steep anterior K, mean anterior K, anterior topographic astigmatism, flat posterior K, steep posterior K, mean posterior K, posterior topographic astigmatism, anterior corneal asphericity, and posterior corneal asphericity were 540.22 (24.47) µm, 1.72 (0.73) µm, 1.63 (0.73) µm, 0.51 (0.17) µm, + 0.31 (0.09) µm, - 0.06 (0.15) diopters (D), 0.003 (0.21) D, 43.87 (1.49) D, 44.69 (1.50) D, 44.28 (1.44) D, + 0.82 (0.83) D, - 6.25 (0.27) D, - 6.55 (0.31) D, - 6.40 (0.28) D, - 0.30 (0.15) D, - 0.32 (0.12) Q-value, and - 0.47 (0.17) Q-value, respectively. Conclusions: We presented the mean values of Pentacam parameters for aberrometry, keratometry, and corneal asphericity in patients with treatment-naive T2DM. These values could serve as a baseline for prospective monitoring of the ocular health status of this cohort and for comparison with future cohorts of patients with well-controlled T2DM. Further studies are required to assess the presence and applicability of ocular changes following intensive blood glucose control in T2DM and further understand the related pathophysiology.

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Hyperglycemia induces corneal endothelial dysfunction through attenuating mitophagy

Cited by 12 publications

References 39 publications

The effects of acute angle closure crisis on corneal endothelial cells in patients with type 2 diabetes mellitus

The effects of acute angle closure crisis on corneal endothelial cells in patients with type 2 diabetes mellitus

Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis

Corneal topography and higher-order aberrations in patients with type 2 diabetes mellitus

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