Hyperglycosylated <scp>hCG</scp>: a Unique Human Implantation and Invasion Factor

Evans, Jemma

doi:10.1111/aji.12459

Cited by 40 publications

(31 citation statements)

References 57 publications

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“…13 β-hCG levels may be very high in uncontrolled trophoblastic invasion and low initial β-hCG levels may indicate that pregnancies cannot be implanted. 7,14 In the light of this information, the fact that as BMI increased, hCG levels decreased in this study shows parallelism with the negative effect of BMI on implantation.…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Kalem¹,

Kalem²,

Gürgan³

2017

TJRMS

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-hCG (beta-human chorionic gonadotrophin) is a pregnancy-associated molecule produced by implanted blastocysts and trophoblastic cells. β-hCG as one of the earliest embryonal signals may be a major regulator in the paracrine embryo-endometrial communication.1,2 β-hCG measurement in serum is a method used routinely for pregnancy test after the IVF (invitro fertilization) procedure.3 Serial measurements of β-hCG is a marker which is also used for distinguishing pregnancies running their course from ectopic pregnancy or spontaneous pregnancy losses in early pregnancy. [4][5][6] In increasing number of recent studies, it has become a current issue that β-hCG levels in early A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The purpose of this study is to investigate the parameters of female, male and cycles that could affect post-ART (assisted reproductive techniques)-pregnancy initial beta hCG value. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : In this retrospective study, data of 3056 individuals who had become pregnant with IVF/ICSI at a private IVF center and between 2006 and 2016 and whose pregnancies continued for over 12 weeks were evaluated. Initial beta-hCG values of these pregnancies were compared with parameters of mothers, fathers and cycles. R Re es su ul lt ts s: : It was seen in this study that there is a negative correlation between the initial beta-hCG values of pregnancies achieved by assisted reproductive techniques and mothers BMI values and a positive correlation between those beta-hCG values and the embryo transfer day. C Co on nc cl lu us si io on n: : The data obtained in the study need to be supported with larger series in the future. It is also thought that these data may contribute to the literature which tries to achieve a β -hCG cut-off value in the determination of pregnancy outcome. Ya zış ma Ad re si/Cor res pon den ce:

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Section: Discussionmentioning

confidence: 99%

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Kalem¹,

Kalem²,

Gürgan³

2017

TJRMS

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“…20,21 However, the recombinant and urine-purified hCG, commonly used to study the role of hCG in vitro and in vivo, are not completely identical. 20 hCG is produced by the placental syncytiotrophoblast cells during pregnancy, and its main function is to maintain progesterone production by the corpus luteum.…”

Section: Hcg and Its Receptors In Endometriummentioning

confidence: 99%

“…Human chorionic gonadotropin is a glycoprotein hormone, and three dimeric isoforms of hCG have been found based on translational modifications. 20 hCG is produced by the placental syncytiotrophoblast cells during pregnancy, and its main function is to maintain progesterone production by the corpus luteum. A sulphated hCG was identified as secreted by the gonadotrope cells of the pituitary and hyperglycosylated hCG (hCG-H) produced by the invasive extravillous cytotrophoblasts and malignant cells of hCG-producing cancers.…”

Section: Hcg and Its Receptors In Endometriummentioning

confidence: 99%

“…A sulphated hCG was identified as secreted by the gonadotrope cells of the pituitary and hyperglycosylated hCG (hCG-H) produced by the invasive extravillous cytotrophoblasts and malignant cells of hCG-producing cancers. 20,21 However, the recombinant and urine-purified hCG, commonly used to study the role of hCG in vitro and in vivo, are not completely identical. Recombinant hCG does not contain the appropriately glycosylated forms as recombinant proteins produced by cell lines are known to be non-or inappropriately glycosylated while high dose of urine-purified hCG likely contains low levels of hCG-H. 20 During pregnancy, hCG is initially transcribed by a four-cell stage embryo 22 and subsequently produced heavily by syncytiotrophoblasts, which are differentiated from the fusion of cytotrophoblasts.…”

Section: Hcg and Its Receptors In Endometriummentioning

confidence: 99%

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Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review

Zhang

Chen

Wang

et al. 2019

American J Rep Immunol

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Intrauterine infusion of human chorionic gonadotropin (IUI‐hCG) has been proposed to improve the outcome of in vitro fertilization‐embryo transfer (IVF‐ET), since it plays a critical role in synchronizing endometrial and fetal development. As the early mediator from embryo, hCG promotes the decidualization, angiogenesis, maternal immune tolerance, and trophoblast invasion, favoring successful implantation of embryo. Although multiple clinical trials have been conducted to verify the efficacy of IUI‐hCG on IVF‐ET outcome in recent years, the findings remained controversial. The difference in study design and population might be the cause to the different consequences after administration of hCG. More importantly, the endometrial receptivity, which might affect the efficacy of IUI‐hCG, has not been assessed in women receiving this intervention. Selecting the right population suitable for IUI‐hCG based on known etiology would be crucial in enhancing its efficacy and minimize any possible complications. Investigation of optimal indications for IUI‐hCG should be highlighted in the future.

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“…Its content is closely related to some diseases, such as gestational trophoblastic disease, germ cell tumors and Down syndrome. [22][23][24] In addition, the quantitative detection of hCG is of great significance to the analysis of clinical medicine and the abuse of stimulants. At present, the detection methods of hCG are mainly electrochemical immunoassay, radioimmunoassay, chemiluminescent immunoassay, fluorescence resonance energy transfer method and optical immunoassay.…”

mentioning

confidence: 99%

A facile and sensitive peptide-modulating graphene oxide nanoribbon catalytic nanoplasmon analytical platform for human chorionic gonadotropin

Liang

et al. 2017

IJN

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The nanogold reaction between HAuCl 4 and citrate is very slow, and the catalyst graphene oxide nanoribbon (GONR) enhanced the nanoreaction greatly to produce gold nanoparticles (AuNPs) that exhibited strong surface plasmon resonance (SPR) absorption (Abs) at 550 nm and resonance Rayleigh scattering (RRS) at 550 nm. Upon addition of the peptide of human chorionic gonadotropin (hCG), the peptide could adsorb on the GONR surface, which inhibited the catalysis. When hCG was added, peptides were separated from the GONR surface due to the formation of stable peptide–hCG complex, which led to the activation of GONR catalytic effect. With the increase in hCG concentration, the RRS and Abs signal enhanced linearly. The enhanced RRS value showed a good linear relationship with hCG concentration in the range of 0.2–20 ng/mL, with a detection limit of 70 pg/mL. Accordingly, two new GONR catalytic RRS/Abs methods were established for detecting hCG in serum samples.

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Hyperglycosylated hCG: a Unique Human Implantation and Invasion Factor

Abstract: CitationEvans J. Hyperglycosylated hCG: a unique human implantation and invasion factor. Am J

Cited by 40 publications

References 57 publications

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review

A facile and sensitive peptide-modulating graphene oxide nanoribbon catalytic nanoplasmon analytical platform for human chorionic gonadotropin

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