Hypergonadotropism in Peripubertal Boys With Chronic Renal Failure

Marder, Harold K.; Srivastava, Laxmi S.; Burstein, Stephen

doi:10.1016/s0022-5347(17)50658-8

Cited by 4 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These and other data are consistent with the ideas that uremia induces the persistence of the peptide factor of 1,000 or 2,000 daltons which may further cause adipo cytes to synthesize a protein which impairs insulin ac tion [8]. This inhibitory factor can also be removed by chronic dialysis and by aerobic exercise training [8], Abnormalities of the hypothalamic-pituitary-gonadal axis (including a late appearing gonadal compromise with resultant hypergonadotropism) [14,15] are also found in uremic children. Initially, a state of hypogonadotropic hypogonadism persists far beyond the usual age for the onset of puberty, but ultimately hypergonadotro pism is found [15].…”

supporting

confidence: 82%

Growth Retardation in Childhood Renal Disease: A Hormonal or Nutritional Problem?

Chesney¹

1987

Am J Nephrol

View full text Add to dashboard Cite

supporting

confidence: 82%

Growth Retardation in Childhood Renal Disease: A Hormonal or Nutritional Problem?

Chesney¹

1987

Am J Nephrol

View full text Add to dashboard Cite

“…(6) demonstrated that children and adolescents with CKD have a significantly decreased number of spermatogonia per seminiferous tubule and fewer germinal cells, compared with age‐matched controls. The most prominent hormonal disturbance is the elevated serum LH levels, whereas FSH and testosterone concentrations are usually normal in children with CKD (5, 7). However, little data exist regarding the reproductive function of children and adolescents after years of successful renal tx.…”

Section: Discussionmentioning

confidence: 99%

“…Throughout their life, male children and adolescents with ESRD would be faced with problems regarding sexual function like delayed puberty, erectile dysfunction, decreased libido, and fertility, which are mainly caused by both impaired spermatogenesis and the disturbances in the pituitary–gonadal axis (1, 2). Hormonal disturbances are usually reversible and recover after successful renal tx (3–5), whereas impaired spermatogenesis may be irreversible. Many potential factors like the duration of uremia, age at tx in children and whether puberty has begun at the time of tx may be responsible.…”

mentioning

confidence: 99%

Evaluation of reproductive functions in male adolescents following renal transplantation

Koyun

Baysal

Usta

et al. 2009

Pediatric Transplantation

View full text Add to dashboard Cite

The aim of this study was to analyze the semen variables and hormone profiles in kidney transplanted male adolescents. Eight post-pubertal male patients who underwent successful renal tx during the peripubertal period and who had ESRD during childhood were enrolled in the study. Patients who underwent tx before 14 yr old (group I) and patients who underwent tx after 14 yr old (group II) were evaluated separately. Semen was collected and analyzed. Serum levels of LH, FSH, and testosterone were measured and found to be normal in all patients except one. The mean age at the diagnosis of CKD was six yr and 13 yr in groups I and II, respectively. The mean age at the time of tx was 12 yr in the first and 17.8 yr in the second group. The patients in group I had received prednisone, cyclosporine A and azathioprine with a longer duration of time compared with patients in group II. Sperm counts (15.5 +/- 15.7 vs. 82.3 +/- 64.2 millions/mL) and sperm motilities (37.8 +/- 30.9 vs. 57.8 +/- 22.1%) were lower in group I than group II. Only one patient in group II had normal sperm parameters and azospermia was observed in one patient from group I. We conclude that the earlier onset and the longer duration of uremia, the more impairment of reproductive function. Also, it seems that duration of exposure to corticosteroids or cyclosporine combined with azathioprine contribute to sperm dysfunction in peripubertal transplanted boys.

show abstract

“…Delayed or abnormal pubertal progression in children with CKD further increases the risk of growth retardation. These children exhibit elevated gonadotrophins with decreased or low–normal gonadal hormones resulting in a state of compensated hypergonadotrophic hypogonadism (Marder et al 1983; Schaefer et al 1991). However, they may also have evidence of hypothalamic-pituitary-gonadal dysregulation with blunted response of luteinising hormone to gonadotrophins and decreased luteinising hormone pulsatility and bioactivity (Blackman et al 1981; Oertel et al 1983; Giusti et al 1991).…”

Section: Pathophysiology Of Growth Impairmentmentioning

confidence: 99%

Growth and body composition in children with chronic kidney disease

Rashid¹,

Neill

Maxwell

et al. 2007

Br J Nutr

View full text Add to dashboard Cite

Growth failure is a common yet complex problem of childhood chronic kidney disease caused by multiple factors encountered due to the primary disease or secondary to the renal impairment. This review seeks to describe the various patho-physiological mechanisms contributing to growth failure in the various stages of childhood with particular emphasis on nutritional problems and endocrine dysfunction encountered whilst managing these children. In addition, we shall examine the role of body composition in chronic kidney disease, their relationship with growth and nutrition and the potential effect of abnormalities in fat mass and lean mass on long-term morbidity and mortality.

show abstract

Hypergonadotropism in Peripubertal Boys With Chronic Renal Failure

Cited by 4 publications

References 0 publications

Growth Retardation in Childhood Renal Disease: A Hormonal or Nutritional Problem?

Growth Retardation in Childhood Renal Disease: A Hormonal or Nutritional Problem?

Evaluation of reproductive functions in male adolescents following renal transplantation

Growth and body composition in children with chronic kidney disease

Contact Info

Product

Resources

About