Hypergravity Conditioning on Ileal Movements in Rats

Kimoto, Mari; Zeredo, Jorge L.; Toda, Kazuo

doi:10.3357/asem.3089.2012

Cited by 6 publications

(11 citation statements)

References 20 publications

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“…One possible explanation is in the way the endocrine system responds to stress in males and females, which is thought to be critical in determining various physiological functions including digestion [10,23]. The present results in relation to somatostatin responsivity expand on previous data that showed sex differences in stress-induced ileal movements [21,22].…”

Section: Discussionsupporting

confidence: 76%

“…The inner contents of the isolated ileum were washed away with Tyrode solution. After that, the isolated ileum was fixed into a Magnus-type chamber filled with Tyrode solution (temperature: 37° C) as reported elsewhere [21]. The proximal end of the preparation was set upward and connected to a strain gauge through a cotton thread (Daruma #30, Yokoi, Osaka, Japan).…”

Section: Ileal Movement Analysismentioning

confidence: 99%

“…Nevertheless, the relationship between stress and somatostatin is still controversial. Further, sex differences are usually observed in stress responses, including changes in digestive function and feeding behavior [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Sex Differences in Ileal Somatostatin-Response after Stress Conditioning in Rats

Kimoto¹,

Zeredo²,

Ota³

et al. 2015

JFNS

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Abstract:We investigated the effects of somatostatin on the ileal movements after gravity stress and compared these effects between male and female rats. Using an in vitro preparation, measurements of ileal movements evoked by somatostatin application were done at 1, 3, 15 and 30 days after 3G gravity loading-conditioning. Mixed phasic and tonic patterns were observed in the ileal muscle activities. Gravity-stress decreased or antagonized somatostatin inhibitory effects on tonic ileal contraction at an early stage (at day 3) in females, but not in males, indicating that sex differences exist in the way that changes of somatostatin sensitivity is modulated by stress conditioning.

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Section: Discussionsupporting

confidence: 76%

Section: Ileal Movement Analysismentioning

confidence: 99%

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Sex Differences in Ileal Somatostatin-Response after Stress Conditioning in Rats

Kimoto¹,

Zeredo²,

Ota³

et al. 2015

JFNS

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“…Therefore, there may be a critical time for stress-induced neuronal changes to take place in the ACCX specifically, or in the limbic system as a whole. In the autonomic system, changes in ileal movements occur 1 day after gravity-stress conditioning (Kimoto, et al, 2012). In a motivated regulatory behavior such as the feeding behavior, changes are observed 14-18 days after gravity stress-conditioning (Kimoto, 2011).…”

Section: Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Stress-induced modulation of nociceptive responses in the rat anterior cingulate cortex

Yamashita

Zeredo

Kaida³

et al. 2013

J. Integr. Neurosci.

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“…The inner contents of the isolated ileum were washed away with Tyrode solution. After that, the isolated ileum was fixed into a Magnus-type chamber filled with Tyrode solution (temperature: 37° C) as reported elsewhere [22]. The proximal end of the preparation was set upward and connected to a strain gauge through a cotton thread (Daruma #30, Yokoi, Osaka, Japan).…”

Section: Methodsmentioning

confidence: 99%

Ginger-induced Ileal Motility is Modified by Stress: Sex Differences in Rats

Kimoto¹,

Zeredo²,

Ota³

et al. 2015

JFNS

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Abstract:Ginger is widely used as a spice and also an effective herbal medicine to treat gastrointestinal disorders. On the other hand, stress can induce various modulation of digestive motility. Here, we investigated ginger effects on stress-induced motility of the isolated ileum in male and female rats, in vitro. Rats (Wistar, SPF, 7-12 weeks of age, 148-393 g BW) were divided into Control (1G) and 3G groups. 3G stress (every day for 10 min) was loaded by centrifugal apparatus for 1, 3, 15 and 30 days. After the stress loading at each day, a 1 cm-long section of the ileum was isolated under barbiturate anesthesia and fixed to a Magnus-type chamber filled with Tyrode solution. Ileal movements were observed for 60 s following application of zingerone, which is also called vanillylacetone and a key component of the pungency of ginger (0.1-10 µM). Spontaneous motility movements with phasic and tonic patterns were observed in the ileum. The former was a peristalsis-like movement and the latter was a slow fluctuation of the baseline. Ginger induced enhanced effects on the rhythmic phasic motility in relation to amplitude. In the female, 3G gravity loading had no effects on the ginger-induced motility, however, suppressive effect of the ginger-induced phasic movements was clearly observed at day 15 in the male. The present study showed that gravity stress changed ginger-induced effects on phasic ileal motility in the male, but not in the female, indicating that sex differences were observed in the ginger effects modulated by stress loading.

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Hypergravity Conditioning on Ileal Movements in Rats

Abstract: INTRODUCTION: Stress is a common trigger for various physiological disturbances

Cited by 6 publications

References 20 publications

Sex Differences in Ileal Somatostatin-Response after Stress Conditioning in Rats

Sex Differences in Ileal Somatostatin-Response after Stress Conditioning in Rats

Stress-induced modulation of nociceptive responses in the rat anterior cingulate cortex

Ginger-induced Ileal Motility is Modified by Stress: Sex Differences in Rats

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