Hyperhomocysteinaemia and poor vitamin B status in chronic obstructive pulmonary disease

Fimognari, Filippo Luca; Loffredo, Lorenzo; Simone, Salvatore Di; Sampietro, Francesca; Pastorelli, Ruggero; Monaldo, M; D’Angelo, Armando

doi:10.1016/j.numecd.2008.12.006

Cited by 45 publications

(45 citation statements)

References 30 publications

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“…All three studies agree that HCY is higher in COPD patients than in controls (Kai et al, 2006;Seemungal et al, 2007;Fimognari et al, 2009). But only one study found that HCY was higher in the more severe COPD (please see Figure 2) (Seemungal et al, 2007).…”

Section: Homocysteine Lung Function and Lung Function Declinesupporting

confidence: 52%

Homocysteine is Elevated in COPD

Seemungal¹,

Ríos²,

Wedzicha³

2012

Chronic Obstructive Pulmonary Disease - Current Concepts and Practice

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Section: Homocysteine Lung Function and Lung Function Declinesupporting

confidence: 52%

Homocysteine is Elevated in COPD

Seemungal¹,

Ríos²,

Wedzicha³

2012

Chronic Obstructive Pulmonary Disease - Current Concepts and Practice

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“…Multiple factors may regulate homocysteine levels, and, as such, determining the main cause(s) of hyperhomocysteinaemia in individual subjects is complex. Previous studies have demonstrated elevated homocysteine levels in COPD subjects, although the mechanism is still unknown [14,15,32].…”

Section: Discussionmentioning

confidence: 97%

“…In addition, high homocysteine levels were shown to be a predictor of FEV1 decline among male current smokers. FIMOGNARI et al [32] demonstrated that homocysteine levels were elevated in COPD patients and that low levels of folate and vitamin B12, as well as hyperglyceridaemia, were independent predictors of hyperhomocysteinaemia. The mechanism for the hyperhomocysteinaemia observed in COPD patients may simply be a decrease in folate and vitamin B12 or increased triglyceride levels.…”

Section: Discussionmentioning

confidence: 99%

Hyperhomocysteinaemia predicts the decline in pulmonary function in healthy male smokers

et al. 2012

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Hyperhomocysteinaemia is associated with chronic obstructive pulmonary disease. However, the relationship between plasma homocysteine levels and spirometric measures has not been investigated in a general population. We aimed to determine whether homocysteine levels are predictive for a rapid decline in lung function among healthy current smokers.Blood sampling and spirometry were performed on subjects participating in a community-based annual health check in Takahata, Japan, from 2004 to 2006 (n53257). Spirometry was re-evaluated in 147 male current smokers in 2009.On initial assessment, forced vital capacity (FVC) % predicted and forced expiratory volume in 1 s (FEV1) % predicted correlated inversely with homocysteine levels and were predictive for homocysteine levels, independent of various clinical factors. Homocysteine levels were higher in subjects with restrictive, obstructive or mixed ventilatory disorders. In addition, homocysteine levels were higher in subjects with mixed ventilatory disorders, compared with restrictive or obstructive disorders. On follow-up, subjects showing a decline in FEV1 had higher homocysteine levels than those who did not. Logistic regression analysis indicated that homocysteine levels were predictive for a decline in FEV1.FVC % pred and FEV1 % pred were significantly associated with homocysteine levels, and hyperhomocysteinaemia predicted the annual rate of decline in FEV1 among male smokers. @ERSpublications Plasma homocysteine levels predict rate of lung function decline in male smokers

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“…Obase et al [127] reported that daily iron intake among 13 COPD patients was about half of that of 27 age-matched controls; however, literature data on mineral intake among COPD patients are limited, so the frequency and severity of true iron deficiency as a cause of anaemia cannot be accurately estimated. Nevertheless, previous studies have indicated that the intake of other micronutrients, such as vitamin B 12 and folic acid is low among COPD patients [128,129], and this could contribute to the establishment of anaemia.…”

Section: Nutritionmentioning

confidence: 95%

Anaemia in chronic obstructive pulmonary disease: an insight into its prevalence and pathophysiology

2014

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Chronic obstructive pulmonary disease (COPD) is a major health problem, with increasing morbidity and mortality. There is a growing literature regarding the extra-pulmonary manifestations of COPD, which can have a significant impact on symptom burden and disease progression. Anaemia is one of the more recently identified co-morbidities, with a prevalence that varies between 4.9% and 38% depending on patient characteristics and the diagnostic criteria used. Systemic inflammation seems to be an important factor for its establishment and repeated bursts of inflammatory mediators during COPD exacerbations could further inhibit erythropoiesis. However, renal impairment, malnutrition, low testosterone levels, growth hormone level abnormalities, oxygen supplementation, theophylline treatment, inhibition of angiotensin-converting enzyme and aging itself are additional factors that could be associated with the development of anaemia. The present review evaluates the published literature on the prevalence and significance of anaemia in COPD. Moreover, it attempts to elucidate the reasons for the high variability reported and investigates the complex pathophysiology underlying the development of anaemia in these patients.

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Hyperhomocysteinaemia and poor vitamin B status in chronic obstructive pulmonary disease

Cited by 45 publications

References 30 publications

Homocysteine is Elevated in COPD

Homocysteine is Elevated in COPD

Hyperhomocysteinaemia predicts the decline in pulmonary function in healthy male smokers

Anaemia in chronic obstructive pulmonary disease: an insight into its prevalence and pathophysiology

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