Hyperhomocysteinemia, and low intakes of folic acid and vitamin B12 in urban North India

Misra, Anoop; Vikram, Naval K.; Pandey, Ravindra Mohan; Dwivedi, Manjari; Ahmad, Faiz U.; Luthra, Kalpana; Jain, Kajal; Khanna, Nidhi; Devi, J. Rama; Sharma, Rekha; Guleria, Randeep

doi:10.1007/s003940200010

Cited by 94 publications

(78 citation statements)

References 37 publications

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“…Vegetarians are more likely to be deficient in vitamin B6, vitamin B 12 , and folate which are the essential cofactors for homocysteine metabolism. Recent evidence strongly suggests that too little vitamin B 12 can lead to high level of homocysteine [28][29][30][31][32][33]. In our study, we have seen that weight and alcohol intake are statistically significant predictors of homocysteine (P = 0.006 and P = 0.036, respectively).…”

Section: Discussionsupporting

confidence: 57%

A Community Based Study of the Relationship Between Homocysteine and Some of the Life Style Factors

Das¹,

Ghose²,

Borah³

et al. 2010

Indian J Clin Biochem

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Till date no community based data on plasma homocysteine is available in North Eastern Region. Hence, the present study was conducted to analyze and correlate the plasma homocysteine level with some life style factors like diet, alcohol intake, smoking habit and body weight, in a cross-section of population. 12 h fasting samples of 970 apparently healthy, Assamese population of both genders in the age group of 35-86 years, mostly from the urban area of Assam were tested for plasma total homocysteine level over a period of 3 years. Out of 970 volunteers, hyperhomocysteinemia was detected in 533 (55%) individuals with a mean value of 18.41 lmol/l. Of that hyperhomocysteinemia, 89.1% were in the range of moderately high and rest 10.9% were intermediate high. Another finding was that males had a tendency towards greater value (mean = 20.36 lmol/l) than females (mean = 16.37 lmol/l). It was observed that the relationship of homocysteine levels to gender and some of the life style factors were also significant.

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Section: Discussionsupporting

confidence: 57%

A Community Based Study of the Relationship Between Homocysteine and Some of the Life Style Factors

Das¹,

Ghose²,

Borah³

et al. 2010

Indian J Clin Biochem

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“…For example, a study in adult slum dwellers in New Delhi, India, found that 93% had folate intakes below the Indian recommended daily allowances (RDAs). 4 Many children in LMICs have suboptimal or poor status of either or both of these nutrients. 5 However, to what extent this situation has any consequences for their health and growth is not clear.…”

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confidence: 99%

Vitamin B-12, Folic Acid, and Growth in 6- to 30-Month-Old Children: A Randomized Controlled Trial

et al. 2015

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BACKGROUND: Folate and vitamin B-12 are important for growth. Many children in low-and middle-income countries have inadequate intakes of these nutrients. METHODS:We undertook a randomized, placebo controlled double-blind trial in 1000 North Indian children, 6 to 35 months of age, providing twice the recommended daily allowance of folic acid and/or vitamin B-12, or placebo, daily for 6 months. By using a factorial design, we allocated children in a 1:1:1:1 ratio in blocks of 16. We measured the effect of giving vitamin B-12, folic acid, or the combination of both on linear and ponderal growth. We also identified predictors for growth in multiple linear regression models and effect modifiers for the effect of folic acid or vitamin B-12 supplementation on growth. RESULTS:The overall effect of either of the vitamins was significant only for weight; children who received vitamin B-12 increased their mean weight-for-age z scores by 0.07 (95% confidence interval: 0.01 to 0.13). Weight-for-age z scores and height-for-age z scores increased significantly after vitamin B-12 supplementation in wasted, underweight, and stunted children. These subgrouping variables significantly modified the effect of vitamin B-12 on growth. Vitamin B-12 status at baseline predicted linear and ponderal growth in children not receiving vitamin B-12 supplements but not in those who did (P-interaction , .001). CONCLUSIONS:We provide evidence that poor vitamin B-12 status contributes to poor growth. We recommend studies with larger doses and longer follow-up to confirm our findings. WHAT'S KNOWN ON THIS SUBJECT:Micronutrient deficiencies, including deficiencies of vitamin B-12 and folate, are common worldwide and may be a contributing factor to the estimated 165 million stunted children. WHAT THIS STUDY ADDS:Routine supplementation of vitamin B-12 improved linear and ponderal growth in subgroups of young Indian children. We provide evidence that vitamin B-12 deficiency is a contributor to poor growth in low-and middle-income countries.

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“…[20][21][22] The mean homocysteine levels too are quite high, varying from 19.5 to 23.2 µmol/L. [20,21] Our study on Western Rajasthan subjects has also revealed a very high mean homocysteine of 34.79 micromole/litre in case group.…”

Section: Discussionmentioning

confidence: 90%

The Study of Biomarker Homocysteine as Risk Factor in Acute Cerebral Stroke Patients of Western Rajasthan

Choudhary¹,

Sharma²,

Soni³

2016

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BACKGROUNDTraditional risk factors for stroke include advanced age, male sex, hypertension, diabetes mellitus, cardiovascular diseases, hyperlipidaemia, obesity, smoking, physical inactivity and psychological factors. However, recent studies indicate that a moderately elevated plasma level of the amino acid homocysteine constitutes an additional risk factor for stroke, coronary heart disease and deep vein thrombosis. The present case control study was undertaken to estimate the biomarker plasma homocysteine level in Cerebrovascular Accident (CVA) cases and normal subjects of Western Rajasthan.

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Hyperhomocysteinemia, and low intakes of folic acid and vitamin B12 in urban North India

Abstract: Low intakes of folic acid and vitamin B12, and hyperhomocysteinemia, in both the healthy population living in urban slums and adjacent urban non-slum areas, are important observations for the prevention of nutritional and cardiovascular diseases in the Indian subcontinent.

Cited by 94 publications

References 37 publications

A Community Based Study of the Relationship Between Homocysteine and Some of the Life Style Factors

A Community Based Study of the Relationship Between Homocysteine and Some of the Life Style Factors

Vitamin B-12, Folic Acid, and Growth in 6- to 30-Month-Old Children: A Randomized Controlled Trial

The Study of Biomarker Homocysteine as Risk Factor in Acute Cerebral Stroke Patients of Western Rajasthan

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