Hyperhomocysteinemia and prevalence of polymorphisms of homocysteine metabolism related enzymes in patients with inflammatory bowel disease

Papa, Alfredo; Danese, Silvio; Grillo, Antonino; Piscaglia, A.C.; Lupascu, A.; Nista, Enrico Celestino; Gasbarrini, G.; Gasbarrini, Antonio

doi:10.1016/s1590-8658(01)80631-9

Cited by 24 publications

(51 citation statements)

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“…Increased Hcys levels and high prevalence of hHcys in IBD patients have been reported in previous studies [31][32][33][34][35][36] . In our study, similar findings were observed in this cohort of UC patients with a slightly higher prevalence of hHcys (30%) than in other studies (10-26%) [31,32,35,36] . Our analysis showed that male sex and low serum levels of folic acid and vitamin B 12 were correlated with high Hcys levels.…”

Section: Discussion Discussion Discussion Discussion Discussionsupporting

confidence: 58%

“…Deficiencies of key nutrients/cofactors in Hcys metabolism pathways (B 2 , B 6 , B 12 , and folate) might lead to raised Hcys levels in IBD. The association between IBD and hHcys has been shown in some recent studies, reporting an increased prevalence of hHcys in IBD (both UC and CD) [31][32][33][34][35][36] . The aim of this study was to evaluate whether Hcys levels were elevated compared to a group of healthy controls and whether Hcys levels were related to vitamin B 12 Serum Hcys levels were also measured in blood samples from 50 healthy control subjects (HC) with similar age and gender (25 females and 25 males, age 39.96±14.33 years, range 17-72 years), under similar conditions and in the same laboratory.…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 80%

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Hyperhomocysteinemia in ulcerative colitis is related to folate levels

Zezos

Papaioannou²,

Nikolaidis³

et al. 2005

WJG

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Abstract Abstract Abstract AIM:To study the prevalence and clinical significance of hyperhomocysteinemia (hHcys), an independent factor for arterial and venous thrombosis, in a group of patients with ulcerative colitis (UC). METHODS:Fasting homocysteine (Hcys), folate, and vitamin B 12 serum levels were measured in 40 UC patients and 50 healthy controls. Clinical data regarding UC were gathered. RESULTS:Median serum Hcys levels in UC patients were similar to those in controls (12.26 μmol/L vs 12.32 μmol/ L), but the prevalence of hHcys was higher in UC patients than in controls (30% vs 10%, P = 0.028). UC significantly increased the risk of hHcys (adjusted odds ratio: 4.125; 95%CI: 1.26-13.44). Multivariate regression analysis showed that male sex, folate and vitamin B 12 deficiency or lower serum values were significant independent predictors of higher Hcys levels in UC patients (r 2 = 0.4; P<0.001).CONCLUSION: hHcys is common in UC patients and it is related to folate and vitamin B 12 deficiency or lower serum values. It would be reasonable for patients with UC to receive folate and vitamin B complex supplements as a prophylactic measure.

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Section: Discussion Discussion Discussion Discussion Discussionsupporting

confidence: 58%

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 80%

Hyperhomocysteinemia in ulcerative colitis is related to folate levels

Zezos

Papaioannou²,

Nikolaidis³

et al. 2005

WJG

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“…In two Italian studies the prevalence of folate deficiency was higher in IBD patients (10%) than in healthy controls regardless of vitamin B 12 deficiency (Table 2; ref. 43) and methylenetetrahydrofolate reductase (MTHFR) or cystathionine b-synthase (CBS) genotype (44). Similarly the studies in Greece and Israel have found that the levels of vitamin B 12 and folate were lower in UC and CD patients than healthy controls but folate deficiency was the only risk factor in developing hyperhomocysteinemia in IBD patients (45).…”

Section: Inflammatory Bowel Disease (Ibd)mentioning

confidence: 99%

Folate status in various pathophysiological conditions

2008

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SummaryFolate is the generic term for compounds that have vitamin activity similar to that of pteroylglutamic acid. Folate acts as a coenzyme in several single carbon transfers involved in biosynthesis of purine nucleotides and deoxythymidylic acid essential for DNA and RNA synthesis. In addition, folate provides onecarbon unit for methylation of a wide variety of biological substances including DNA, proteins, phospholipids, and neurotransmitters, thereby regulating their function. Recent epidemiological-clinical and experimental studies suggest the association of folate deficiency with the risk of various cancers, birth defects, and cardiovascular diseases. Thus, it is important to consider the conditions that are associated with altered folate status and their consequences. The impairment in folate status has been found in number of pathophysiological conditions like inflammatory bowel disease, cancer, alcoholism, pregnancy, neonatal growth, and during administration of some drugs. The recent advances dealing with mechanistic aspects of impaired folate status in these conditions have been discussed in this review. IUBMBIUBMB Life, 60(12): 834-842, 2008

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“…23 Recent studies have focused on elevated plasma homocysteine as a potential contributing factor in IBD hypecoagulability. Modest increases in homocysteine levels have been found in IBD patient populations, [24][25][26][27][28][29] and subsets of patients have also been identified as more likely to have elevated homocysteine levels. 30…”

Section: 3 a Review From Talbot Et Al 1 Frommentioning

confidence: 99%